INT134476

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.88
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Cdk5, Map2k1) plasma membrane (Cdk5, Map2k1) cytoplasm (Cdk5, Map2k1)
cytosol (Cdk5, Map2k1) cytoskeleton (Cdk5, Map2k1) kinase activity (Cdk5, Map2k1)
Cdk5 (Mus musculus)
Map2k1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 1 97.28 Very High Very High Very High
Pain 6 88.64 High High
Morphine 1 88.00 High High
Peripheral nervous system 1 84.60 Quite High
Opioid 2 80.80 Quite High
tolerance 2 80.24 Quite High
Analgesic 1 67.68 Quite High
nociceptor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 3 98.76 Very High Very High Very High
INFLAMMATION 1 97.28 Very High Very High Very High
Targeted Disruption 2 95.52 Very High Very High Very High
Pain 3 88.64 High High
Neurodegenerative Disease 1 79.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we report that Cdk5 regulates mitogen-activated protein kinase kinase1/2 (MEK1/2) activity through a negative feedback loop during the peripheral inflammatory response.
Cdk5 Regulation (regulates) of MEK1 associated with inflammatory response
1) Confidence 0.69 Published 2006 Journal Cell Cycle Section Abstract Doc Link 16552189 Disease Relevance 0.88 Pain Relevance 0.71

General Comments

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