INT134477

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.13
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (SHH) endoplasmic reticulum (SHH) embryo development (SHH)
cell-cell signaling (SHH) signal transducer activity (SHH) peptidase activity (SHH)
SHH (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 96.12 Very High Very High Very High
antagonist 1 86.64 High High
tolerance 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 3 100.00 Very High Very High Very High
Pancreatic Cancer 4 97.12 Very High Very High Very High
Pancreatitis 2 96.12 Very High Very High Very High
Disease 5 91.76 High High
Medulloblastoma 10 85.68 High High
Cancer 32 84.32 Quite High
Apoptosis 3 5.00 Very Low Very Low Very Low
Brain Tumor 2 5.00 Very Low Very Low Very Low
Metastasis 1 5.00 Very Low Very Low Very Low
Cerebral Palsy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, it has been shown that deregulation of hedgehog signaling molecules contributes to the pathogenesis and progression of pancreatic cancer and of chronic pancreatitis.
Negative_regulation (deregulation) of hedgehog associated with pancreatic cancer and chronic pancreatitis
1) Confidence 0.37 Published 2006 Journal Pancreas Section Abstract Doc Link 16552330 Disease Relevance 0.57 Pain Relevance 0.20
Gli1 activates Ptc1 expression and thus counters, to some extent Shh repression of Ptc1 activity [33,35,38].
Negative_regulation (repression) of Shh associated with repression
2) Confidence 0.34 Published 2007 Journal BMC Syst Biol Section Body Doc Link PMC1839891 Disease Relevance 0.56 Pain Relevance 0

General Comments

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