INT134505

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.81
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Abcc2)
Anatomy Link Frequency
bile 2
Abcc2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 7 97.90 Very High Very High Very High
Paracetamol 8 91.20 High High
ischemia 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Taxol 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 32 88.80 High High
Cancer 78 83.00 Quite High
Osteogenic Sarcomas 2 79.64 Quite High
Plasmacytoma 4 78.96 Quite High
Gallstones 4 75.00 Quite High
Metastasis 8 66.00 Quite High
Shock 20 50.00 Quite Low
Disease 2 33.28 Quite Low
Fever 14 17.28 Low Low
Hodgkin's Disease 2 13.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The EE+SL group showed increased levels of Mrp2 and Mrp3 to the same extent as that registered for the individual treatments.
Positive_regulation (increased) of Gene_expression (levels) of Mrp2
1) Confidence 0.69 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17686906 Disease Relevance 0.15 Pain Relevance 0.16
In conclusion, SL administration to EE-induced cholestatic rats counteracted the decrease in bile flow and biliary excretion of glutathione and APAP-glu, a model Mrp substrate, findings associated with up-regulation of Mrp2 expression.
Positive_regulation (up-regulation) of Gene_expression (expression) of Mrp2 in bile associated with bile
2) Confidence 0.69 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17686906 Disease Relevance 0.07 Pain Relevance 0.15
Western blotting analysis revealed decreased Mrp2 (-41%) and increased Mrp3 (+200%) expression by EE.
Positive_regulation (increased) of Gene_expression (expression) of Mrp2
3) Confidence 0.66 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16554369 Disease Relevance 0 Pain Relevance 0.40
Despite high concentrations of the cytostatic drug and the exposition towards hyperthermic temperatures, only temporary effects on gene expression, that is, mrp1 (suppression) and mrp2 (induction) could be observed.
Positive_regulation (induction) of Gene_expression (expression) of mrp2
4) Confidence 0.18 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.80 Pain Relevance 0
Despite high concentrations of the cytostatic drug and the exposition towards hyperthermic temperatures, only temporary effects on gene expression, that is, mrp1 (suppression) and mrp2 (induction) could be observed.
Positive_regulation (induction) of Gene_expression (suppression) of mrp2
5) Confidence 0.18 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.79 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox