INT134506

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.06
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Abcc2)
Anatomy Link Frequency
kidney 1
Abcc2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 16 95.40 Very High Very High Very High
Bile 4 87.64 High High
Disease Link Frequency Relevance Heat
Breast Cancer 1 63.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blotting analysis revealed decreased Mrp2 (-41%) and increased Mrp3 (+200%) expression by EE.
Negative_regulation (decreased) of Mrp2
1) Confidence 0.41 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16554369 Disease Relevance 0 Pain Relevance 0.33
Western studies revealed decreased levels of apical Mrp2 in liver and jejunum but increased levels in renal cortex from BDL animals, whereas Mrp3 was substantially increased in liver and not affected in kidney or intestine.
Negative_regulation (decreased) of Mrp2 in kidney
2) Confidence 0.41 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 18096675 Disease Relevance 0.06 Pain Relevance 0.84

General Comments

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