INT134512

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Context Info
Confidence 0.22
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.31
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Dct) cytosol (Dct) oxidoreductase activity (Dct)
cytoplasm (Dct)
Anatomy Link Frequency
DCT 2
head 1
Dct (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 4 95.52 Very High Very High Very High
cINOD 1 56.88 Quite High
COX-2 inhibitor 1 36.16 Quite Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 18 99.80 Very High Very High Very High
Apoptosis 3 97.48 Very High Very High Very High
Hypomagnesemia 12 91.52 High High
Pressure Volume 2 Under Development 1 90.72 High High
Ocular Hypertension 43 90.64 High High
Glaucoma 9 90.44 High High
Cicatrix 1 88.28 High High
Bartter Syndrome 8 85.04 High High
Targeted Disruption 4 74.72 Quite High
Congenital Anomalies 6 73.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, a HS diet provokes a rapid and persistent redistribution of NCC from apical to subapical membranes, a mechanism that would facilitate a homeostatic decrease in NaCl reabsorption in the DCT to compensate for increased dietary salt.
Negative_regulation (decrease) of DCT in DCT
1) Confidence 0.22 Published 2006 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 16554416 Disease Relevance 0 Pain Relevance 0.07
For the measurement with the DCT, the subjects were placed at the slitlamp and the head of the DCT was centered on the cornea similarly to Goldmann applanation tonometry.
Negative_regulation (centered) of DCT in head
2) Confidence 0.11 Published 2004 Journal BMC Ophthalmol Section Body Doc Link PMC394329 Disease Relevance 0.39 Pain Relevance 0.10
However, much higher dose of HCTZ compared to the dose of HCTZ in our study was utilized in their study and high dose of HCTZ might reduce distal convoluted tubule (DCT) density itself resulting in the decrement of Ca2+ transporters because a similar dose of HCTZ was reported to induce apoptosis in the DCT cells (24).
Spec (might) Negative_regulation (reduce) of DCT in DCT associated with apoptosis
3) Confidence 0.11 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.17 Pain Relevance 0
Therefore, patient with GS may have reduced DCT epithelial surface area, which limits magnesium reabsorption.
Negative_regulation (reduced) of DCT associated with syndrome
4) Confidence 0.08 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1481527 Disease Relevance 1.75 Pain Relevance 0.06

General Comments

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