INT134515

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 9
Disease Relevance 9.57
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc12a3) transport (Slc12a3) plasma membrane (Slc12a3)
transmembrane transport (Slc12a3)
Anatomy Link Frequency
kidney 3
distal convoluted tubule 1
ascending limb 1
tubule 1
Slc12a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 7 95.80 Very High Very High Very High
antagonist 21 90.48 High High
anesthesia 22 72.84 Quite High
Action potential 1 40.92 Quite Low
isoflurane 28 28.80 Quite Low
fibrosis 7 5.00 Very Low Very Low Very Low
medulla 7 5.00 Very Low Very Low Very Low
sodium channel 6 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 868 99.84 Very High Very High Very High
Bartter Syndrome 104 98.66 Very High Very High Very High
Hypertrophy 77 95.20 Very High Very High Very High
Polyuria 8 80.60 Quite High
Uremia 28 79.60 Quite High
Pressure Volume 2 Under Development 2 78.92 Quite High
Hypertension 1 75.80 Quite High
Disease 4 67.84 Quite High
Myocardial Infarction 2 56.28 Quite High
Arrhythmia Under Development 1 44.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Redistribution of distal tubule Na+-Cl- cotransporter (NCC) in response to a high-salt diet.
Gene_expression (Redistribution) of NCC in tubule
1) Confidence 0.68 Published 2006 Journal Am. J. Physiol. Renal Physiol. Section Title Doc Link 16554416 Disease Relevance 0 Pain Relevance 0.07
In the great majority of cases GS is caused by mutations in the solute carrier family 12, member 3, SLC12A3 gene, which encodes the renal thiazide-sensitive sodium-chloride co-transporter NCC that is specifically expressed in the apical membrane of cells in the first part of the distal convoluted tubule (DCT) (reviewed in [9]).
Gene_expression (expressed) of SLC12A3 in distal convoluted tubule associated with bartter syndrome
2) Confidence 0.39 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2518128 Disease Relevance 0.80 Pain Relevance 0
The decreased AQP2 expression in CRF rats was not altered in response to candesartan treatment; 3) Candesartan treatment was associated with decreased NHE3 and TSC expression in CRF, which could be due to the Ang II AT1 receptor blockade and/or decreased aldosterone levels; and 4) BSC-1 expression was increased in both CRF groups and the increased expression of BSC-1 was more prominent in candesartan-treated CRF rats compared with vehicle-treated CRF rats.
Gene_expression (expression) of TSC associated with chronic renal failure
3) Confidence 0.20 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 1.28 Pain Relevance 0
Kidney expression of NHE3 and TSC was decreased in CRF rats treated with candesartan (CRF-C)
Gene_expression (expression) of TSC in Kidney associated with chronic renal failure
4) Confidence 0.20 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 1.34 Pain Relevance 0
Moreover, densitometric analysis revealed that candesartan treatment significantly decreased whole kidney TSC expression in CRF rats (27±13% of sham-operated control level, p<0.05, Fig. 6, Table 2), whereas whole kidney TSC expression was unchanged in CRF rats treated with vehicle only (75±16% of sham-operated control level, n.s., Fig. 6, Table 2).


Gene_expression (expression) of TSC in kidney associated with chronic renal failure
5) Confidence 0.17 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 1.24 Pain Relevance 0
In the present study, we aimed to examine the effects of AngII AT1 receptor blockade on the expression of major renal sodium transporters (NHE3, BSC-1, and TSC) and vasopressin-regulated aquaporin-2 (AQP2) in rats with an early stage of CRF induced by 5/6 nephrectomy.
Spec (examine) Gene_expression (expression) of TSC associated with chronic renal failure
6) Confidence 0.17 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.30 Pain Relevance 0.14
Moreover, densitometric analysis revealed that candesartan treatment significantly decreased whole kidney TSC expression in CRF rats (27±13% of sham-operated control level, p<0.05, Fig. 6, Table 2), whereas whole kidney TSC expression was unchanged in CRF rats treated with vehicle only (75±16% of sham-operated control level, n.s., Fig. 6, Table 2).


Gene_expression (expression) of TSC in kidney associated with chronic renal failure
7) Confidence 0.17 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 1.23 Pain Relevance 0
In conclusion, 1) candesartan treatment in an early phase of CRF is associated with decreased renal hypertrophy and increased BUN level; 2) decreased AQP2 level in CRF is likely to play a role in the decreased urine concentration, and the downregulation is not altered in response to candesartan treatment; 3) candesartan treatment decreases NHE3 and TSC expression; and 4) an increase of BSC-1 is prominent in candesartan-treated CRF rats, which could be associated with the increased delivery of sodium and water to the thick ascending limb.



Gene_expression (expression) of TSC in ascending limb associated with hypertrophy and chronic renal failure
8) Confidence 0.16 Published 2005 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2808601 Disease Relevance 1.48 Pain Relevance 0
In contrast, the expression of NHE3 (25%) and TSC (27%) was decreased in CRF-C, whereas no changes were observed in CRF-V.
Gene_expression (expression) of TSC associated with chronic renal failure
9) Confidence 0.14 Published 2005 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2808601 Disease Relevance 1.89 Pain Relevance 0

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