INT134516

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2006
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.23
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc12a3) transport (Slc12a3) plasma membrane (Slc12a3)
transmembrane transport (Slc12a3)
Anatomy Link Frequency
tubule 2
kidney 2
Slc12a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 4 73.36 Quite High
isoflurane 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
bradykinin 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 124 99.84 Very High Very High Very High
Hypertrophy 11 20.72 Low Low
Uremia 4 5.00 Very Low Very Low Very Low
Natriuresis 2 5.00 Very Low Very Low Very Low
Fibrosis 1 5.00 Very Low Very Low Very Low
Disorders Of Creatine Metabolism 1 5.00 Very Low Very Low Very Low
Bartter Syndrome 1 5.00 Very Low Very Low Very Low
Hypercalcemia 1 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Redistribution of distal tubule Na+-Cl- cotransporter (NCC) in response to a high-salt diet.
Positive_regulation (response) of Gene_expression (Redistribution) of NCC in tubule
1) Confidence 0.50 Published 2006 Journal Am. J. Physiol. Renal Physiol. Section Title Doc Link 16554416 Disease Relevance 0 Pain Relevance 0.07
Moreover, densitometric analysis revealed that candesartan treatment significantly decreased whole kidney TSC expression in CRF rats (27±13% of sham-operated control level, p<0.05, Fig. 6, Table 2), whereas whole kidney TSC expression was unchanged in CRF rats treated with vehicle only (75±16% of sham-operated control level, n.s., Fig. 6, Table 2).


Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (expression) of TSC in kidney associated with chronic renal failure
2) Confidence 0.11 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 1.23 Pain Relevance 0

General Comments

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