INT134527

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.72
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ntrk2) endosome (Ntrk2) aging (Ntrk2)
plasma membrane (Ntrk2)
Anatomy Link Frequency
neuronal 1
spinal cord 1
dorsal root ganglia 1
Schwann cell 1
Ntrk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 5 100.00 Very High Very High Very High
Spinal cord 40 99.58 Very High Very High Very High
long-term potentiation 34 99.20 Very High Very High Very High
bDMF 136 99.04 Very High Very High Very High
Inflammation 10 98.28 Very High Very High Very High
Nerve growth factor 21 97.50 Very High Very High Very High
Stimulus evoked pain 18 94.88 High High
agonist 7 94.88 High High
Pain 37 93.24 High High
antidepressant 25 91.32 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 13 98.28 Very High Very High Very High
Pain 54 94.88 High High
Hypersensitivity 18 94.68 High High
Hyperglycemia 4 89.24 High High
Diabetes Mellitus 14 88.52 High High
Neointima 22 87.48 High High
Neuropathic Pain 35 86.00 High High
Injury 41 85.88 High High
Hyperplasia 8 81.76 Quite High
Cardiovascular Disease 4 80.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They induced differentiation of chick dorsal root ganglia and stimulated tyrosine phosphorylation of TrkA, but not TrkB, receptor.
Phosphorylation (phosphorylation) of TrkB in dorsal root ganglia
1) Confidence 0.69 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18337399 Disease Relevance 0.24 Pain Relevance 0.44
Here we found that, in cultured rat cortical neurons, bidirectional changes of neuronal activity led to corresponding alterations in the expression of brain-derived neurotrophic factor (BDNF) and phosphorylation of its receptor tropomyosin-related kinase B (TrkB), as well as in the level of synaptic proteins.
Phosphorylation (phosphorylation) of TrkB in neuronal
2) Confidence 0.65 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18474605 Disease Relevance 0 Pain Relevance 0.08
This was paralleled by greater levels of phosphorylated (ie activated) TrkB in the light membrane fraction, that contains signaling endosomes.
Phosphorylation (phosphorylated) of TrkB
3) Confidence 0.56 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16554746 Disease Relevance 0 Pain Relevance 0.47
Thus, BDNF-LTP is associated with rapid and transient phosphorylation of two translation factors critical in controlling global translation initiation and elongation rates, eukaryotic initiation factor 4E (eIF4E), and elongation factor-2 (eEF2) [62].
Phosphorylation (phosphorylation) of factors associated with long-term potentiation
4) Confidence 0.21 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0 Pain Relevance 0.48
Given that the increased NGF in response to peripheral inflammation could induce the upregulation of BDNF in the DRG and spinal cord, which subsequently phosphorylated the downstream signals including NMDA receptor subunit NR1, tropomyosine receptor kinase B (TrkB) and extracellular regulating kinase (ERK) [15,16], it is possible that BDNF is also associated with the incision-evoked pain hypersensitivity.
Phosphorylation (phosphorylated) of tropomyosine receptor kinase B in spinal cord associated with inflammation, nerve growth factor, nmda receptor, hypersensitivity, stimulus evoked pain, bdmf and spinal cord
5) Confidence 0.15 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 1.73 Pain Relevance 2.03
Insulin induces increased expression of translation initiation factors and phosphorylation of 4EBP-1 and S6K, critical cell cycle regulators downstream of mTOR.
Phosphorylation (phosphorylation) of factors
6) Confidence 0.01 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.64 Pain Relevance 0.04
To determine whether factors upstream of the Akt-mTOR-P70S6K system regulate phosphorylation of this system, inhibitors of upstream molecules were added to cells prior to treatment with insulin.
Phosphorylation (phosphorylation) of factors
7) Confidence 0.01 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.97 Pain Relevance 0.03
Whether there is a relationship between these growth factors and ERK phosphorylation during Schwann cell proliferation remains to be studied.
Phosphorylation (phosphorylation) of factors in Schwann cell
8) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501035 Disease Relevance 0.13 Pain Relevance 0.08

General Comments

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