INT134534

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Bdnf (Rattus norvegicus)
Psds1 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 6 100.00 Very High Very High Very High
Hippocampus 4 92.52 High High
Glutamate receptor 2 80.76 Quite High
fluoxetine 8 75.00 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We propose that BDNF, whose synthesis is increased by antidepressants, and which is in part released at synaptic sites, binds to TrkB in PSDs, leading to the internalization of the BDNF-TrkB complex and, thus, to a decrease of TrkB in the PSDs.
BDNF Binding (binds) of PSDs associated with antidepressant
1) Confidence 0.01 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16554746 Disease Relevance 0 Pain Relevance 0.52
We propose that BDNF, whose synthesis is increased by antidepressants, and which is in part released at synaptic sites, binds to TrkB in PSDs, leading to the internalization of the BDNF-TrkB complex and, thus, to a decrease of TrkB in the PSDs.
BDNF Binding (binds) of PSDs associated with antidepressant
2) Confidence 0.01 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16554746 Disease Relevance 0 Pain Relevance 0.52

General Comments

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