INT13454

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Context Info
Confidence 0.68
First Reported 1980
Last Reported 2008
Negated 3
Speculated 4
Reported most in Abstract
Documents 49
Total Number 53
Disease Relevance 14.53
Pain Relevance 18.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh) signal transduction (Gh) mitochondrion (Gh)
extracellular space (Gh) extracellular region (Gh) plasma membrane (Gh)
Anatomy Link Frequency
plasma 12
hypothalamus 2
thyroid 2
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 89 100.00 Very High Very High Very High
Morphine 18 100.00 Very High Very High Very High
Sumatriptan 47 99.98 Very High Very High Very High
Somatostatin 84 99.96 Very High Very High Very High
Desipramine 6 99.84 Very High Very High Very High
opiate 10 99.80 Very High Very High Very High
narcan 37 99.36 Very High Very High Very High
dexamethasone 23 99.30 Very High Very High Very High
Migraine 4 99.04 Very High Very High Very High
agonist 25 98.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Body Weight 6 100.00 Very High Very High Very High
Hypoglycemia 13 99.98 Very High Very High Very High
Obesity 46 99.80 Very High Very High Very High
Depression 11 99.72 Very High Very High Very High
Diabetes Mellitus 17 99.24 Very High Very High Very High
Headache 9 99.04 Very High Very High Very High
Disease 31 98.80 Very High Very High Very High
Eating Disorder 24 98.08 Very High Very High Very High
Sleep Disorders 2 97.96 Very High Very High Very High
Syndrome 28 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine caused an elevation of growth hormone in both acromegalics and normal subjects (p < 0.05).
Positive_regulation (caused) of Positive_regulation (elevation) of growth hormone associated with morphine
1) Confidence 0.68 Published 2005 Journal Horm. Metab. Res. Section Abstract Doc Link 16034714 Disease Relevance 0.41 Pain Relevance 0.65
CLON (1.5 and 2.0 micrograms/kg) induced a significant dose-dependent GH increase, but only the 2.0 micrograms/kg dose differentiated GH responders from nonresponders.
Positive_regulation (induced) of Positive_regulation (increase) of GH associated with clonidine
2) Confidence 0.64 Published 1988 Journal Psychoneuroendocrinology Section Abstract Doc Link 3060889 Disease Relevance 0.10 Pain Relevance 1.03
Sumatriptan did induce a significant increase in plasma growth hormone (GH) levels.
Positive_regulation (induce) of Positive_regulation (increase) of GH in plasma associated with sumatriptan
3) Confidence 0.59 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9877016 Disease Relevance 0.82 Pain Relevance 0.72
Twelve patients with DSM-III-R major depressive illness were tested for growth hormone (GH) response to desipramine (DMI), a noradrenergic (NA) reuptake inhibitor.
Positive_regulation (tested) of Positive_regulation (response) of GH associated with desipramine and depression
4) Confidence 0.50 Published 1991 Journal Biol. Psychiatry Section Abstract Doc Link 1912129 Disease Relevance 0.10 Pain Relevance 0.47
Twelve patients with DSM-III-R major depressive illness were tested for growth hormone (GH) response to desipramine (DMI), a noradrenergic (NA) reuptake inhibitor.
Positive_regulation (tested) of Positive_regulation (response) of growth hormone associated with desipramine and depression
5) Confidence 0.50 Published 1991 Journal Biol. Psychiatry Section Abstract Doc Link 1912129 Disease Relevance 0.10 Pain Relevance 0.47
METHOD: Twelve patients (six women and six men) with major depression diagnosed according to DSM-III-R underwent dexamethasone-induced GH stimulation before and after random assignment to 4 weeks of treatment with either placebo (N = 6) or fluoxetine (N = 6).
Positive_regulation (dexamethasone-induced) of Positive_regulation (stimulation) of GH
6) Confidence 0.50 Published 1995 Journal Am J Psychiatry Section Body Doc Link 7694914 Disease Relevance 0 Pain Relevance 0
We conclude that it is not uncommon for stimulated GH concentrations to underestimate spontaneous GH secretion.
Positive_regulation (underestimate) of Neg (not) Positive_regulation (stimulated) of GH
7) Confidence 0.49 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1671784 Disease Relevance 0 Pain Relevance 0.05
Sumatriptan induced a significant (P<0.01) increase in GH concentrations both in migraine patients and healthy controls.
Positive_regulation (induced) of Positive_regulation (increase) of GH associated with sumatriptan and migraine
8) Confidence 0.47 Published 2000 Journal Cephalalgia Section Abstract Doc Link 10999671 Disease Relevance 0.26 Pain Relevance 0.77
Although no significant GH release was observed after dexamethasone or clonidine in GH deficiency, an increase in GH after GH-releasing hormone was seen (6.1 +/- 1.9 micrograms/l).
Positive_regulation (seen) of Positive_regulation (increase) of GH associated with dexamethasone and clonidine
9) Confidence 0.47 Published 1997 Journal Horm. Res. Section Abstract Doc Link 9195203 Disease Relevance 0 Pain Relevance 0.52
Although no significant GH release was observed after dexamethasone or clonidine in GH deficiency, an increase in GH after GH-releasing hormone was seen (6.1 +/- 1.9 micrograms/l).
Positive_regulation (seen) of Positive_regulation (increase) of GH associated with dexamethasone and clonidine
10) Confidence 0.47 Published 1997 Journal Horm. Res. Section Abstract Doc Link 9195203 Disease Relevance 0 Pain Relevance 0.52
Sumatriptan did induce a significant increase in plasma growth hormone (GH) levels.
Positive_regulation (induce) of Positive_regulation (increase) of growth hormone in plasma associated with sumatriptan
11) Confidence 0.43 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9877016 Disease Relevance 0.82 Pain Relevance 0.72
Since the alpha adrenergic system plays an important role in hypothalamic regulation of GH secretion, we tested the hypothesis that altered central adrenergic activity contributes to the increased GH concentrations in diabetes.
Positive_regulation (contributes) of Positive_regulation (increased) of GH associated with diabetes mellitus
12) Confidence 0.41 Published 1985 Journal Pediatr. Res. Section Abstract Doc Link 2989759 Disease Relevance 0.42 Pain Relevance 0.27
The exercise-induced norepinephrine, epinephrine, testosterone, cortisol (COR), and growth hormone (GH) increases were similar in the 2 exercises, although the overall level of COR and GH, including the preexercise concentrations, tended to decline in the second exercise.
Positive_regulation (exercise-induced) of Positive_regulation (increases) of growth hormone
13) Confidence 0.39 Published 2002 Journal J Strength Cond Res Section Abstract Doc Link 12173952 Disease Relevance 0.33 Pain Relevance 0
The clonidine test induced a significantly greater GH response during poor than during improved metabolic control in the diabetic patients (AUC 2598 +/- 492 vs. 1508 +/- 368 microg/l x min, p < 0.05); this response was greater than in the control subjects (670 +/- 226 x microg/l x min, p < 0.005 vs. improved metabolic control).
Positive_regulation (induced) of Positive_regulation (response) of GH associated with diabetes mellitus and clonidine
14) Confidence 0.39 Published 1999 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 10533850 Disease Relevance 0.47 Pain Relevance 0.48
The exercise-induced norepinephrine, epinephrine, testosterone, cortisol (COR), and growth hormone (GH) increases were similar in the 2 exercises, although the overall level of COR and GH, including the preexercise concentrations, tended to decline in the second exercise.
Positive_regulation (exercise-induced) of Positive_regulation (increases) of GH
15) Confidence 0.39 Published 2002 Journal J Strength Cond Res Section Abstract Doc Link 12173952 Disease Relevance 0.33 Pain Relevance 0
The mean GH increase after 18 months was 33.8 ?
Positive_regulation (mean) of Positive_regulation (increase) of GH
16) Confidence 0.33 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.33 Pain Relevance 0.12
Clonidine induced sharp, marked reductions of NE, CRT and DBP, plus a sudden increase of GH, in all the patients during exacerbation periods.
Positive_regulation (induced) of Positive_regulation (increase) of GH associated with clonidine
17) Confidence 0.33 Published 1987 Journal Psychoneuroendocrinology Section Abstract Doc Link 3602260 Disease Relevance 0.24 Pain Relevance 0.31
Propionate and butyrate at 10 mmol/l, however, not only suppressed basal GH release but also significantly reduced the GH increase induced by 10 nmol/l of GHRH.
Positive_regulation (induced) of Positive_regulation (increase) of GH
18) Confidence 0.33 Published 1999 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 10484133 Disease Relevance 0 Pain Relevance 0.39
In principle, treatment with GHS should offer a more physiologic approach to GH replacement, leading to a pulsatile rather than prolonged elevation in GH and preserving the capability for negative feedback inhibition of GH by rising levels of IGF-I (Merriam et al 2000; Merriam 2002).
Positive_regulation (leading) of Positive_regulation (elevation) of GH
19) Confidence 0.32 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544358 Disease Relevance 0.30 Pain Relevance 0.04
Once daily GHRH injections can stimulate increases in GH and IGF-I at least to the lower part of the young adult normal range (Merriam et al 2000).
Positive_regulation (stimulate) of Positive_regulation (increases) of GH
20) Confidence 0.32 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544358 Disease Relevance 0.21 Pain Relevance 0.04

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