INT134544

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 31
Disease Relevance 18.48
Pain Relevance 5.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CASP3) mitochondrion (CASP3) cytoplasm (CASP3)
cytosol (CASP3) peptidase activity (CASP3) nucleolus (CASP3)
Anatomy Link Frequency
cleavage 2
brain 2
nucleus 2
OGE 2
CASP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
isoflurane 43 100.00 Very High Very High Very High
Neuritis 2 100.00 Very High Very High Very High
lidocaine 1 100.00 Very High Very High Very High
nMDA receptor 17 99.76 Very High Very High Very High
dexamethasone 130 99.20 Very High Very High Very High
Abeta 7 98.82 Very High Very High Very High
metalloproteinase 16 98.20 Very High Very High Very High
anesthesia 5 97.96 Very High Very High Very High
antagonist 11 93.72 High High
Inflammation 184 93.60 High High
Disease Link Frequency Relevance Heat
Shock 4 100.00 Very High Very High Very High
Neuritis 2 100.00 Very High Very High Very High
Apoptosis 1589 99.92 Very High Very High Very High
Death 151 98.68 Very High Very High Very High
Alzheimer's Dementia 16 98.20 Very High Very High Very High
Leukemia 11 98.00 Very High Very High Very High
Delirium 3 97.42 Very High Very High Very High
Dementia 5 97.16 Very High Very High Very High
Neurodegenerative Disease 11 95.36 Very High Very High Very High
Cancer 149 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Treatment with curcumin and resveratrol suppressed NF-kappaB-regulated gene products involved in inflammation (cyclooxygenase-2, matrix metalloproteinase (MMP)-3, MMP-9, vascular endothelial growth factor), inhibited apoptosis (Bcl-2, Bcl-xL, and TNF-alpha receptor-associated factor 1) and prevented activation of caspase-3.
Negative_regulation (prevented) of Positive_regulation (activation) of caspase-3
1) Confidence 0.57 Published 2009 Journal Arthritis Res. Ther. Section Body Doc Link 19889203 Disease Relevance 0.06 Pain Relevance 0
However, the quenching of ROS generation in response to treatment with a ROS scavenger, N-acetyl-L-cysteine, reversed the platycodon D-induced apoptosis effects via inhibition of Egr-1 activation, ROS production, MMP collapse, and the subsequent activation of caspase-3.
Negative_regulation (inhibition) of Positive_regulation (activation) of caspase-3 associated with shock and apoptosis
2) Confidence 0.44 Published 2009 Journal Biomed. Pharmacother. Section Abstract Doc Link 18804340 Disease Relevance 0.84 Pain Relevance 0.13
In addition, glyoxalase I inhibition leads to reduced cell viability, strongly retracted neuritis, increase in [Ca(2+)](i), and activation of caspase-3.
Negative_regulation (reduced) of Positive_regulation (activation) of caspase-3 associated with neuritis
3) Confidence 0.41 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16555297 Disease Relevance 0.66 Pain Relevance 0.10
To address the molecular mechanisms of dementia and delirium associated with anesthesia and surgery, we assessed whether the Abeta fibrillar aggregation inhibitor Congo red can attenuate isoflurane-induced caspase-3 activation in H4 human neuroglioma cells overexpressing human beta-amyloid precursor protein (APP).
Negative_regulation (attenuate) of Positive_regulation (activation) of caspase-3 associated with anesthesia, dementia, alzheimer's dementia, delirium, isoflurane and abeta
4) Confidence 0.34 Published 2006 Journal J. Gerontol. A Biol. Sci. Med. Sci. Section Abstract Doc Link 17234824 Disease Relevance 0.86 Pain Relevance 0.37
Thus, pretreatment of cells with DXM prior to treatment with TMZ appeared to decrease the upregulation of caspase-3 activity.
Negative_regulation (decrease) of Positive_regulation (upregulation) of caspase-3 associated with dexamethasone
5) Confidence 0.26 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 0 Pain Relevance 0.25
Treatment of cells with DXM prior to TMZ appeared to significantly decrease the activation of caspase-3 (panel C, Fig. 6), indicating an inhibitory effect of DXM on TMZ induced caspase-3 activation.


Negative_regulation (decrease) of Positive_regulation (activation) of caspase-3 associated with dexamethasone
6) Confidence 0.26 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 0.23 Pain Relevance 0.29
At doses of 25, 75, and 150 mJ/cm2 of UVB, cells treated with HMW-HA showed a clear decrease in the activation of caspase-3 (?
Spec (clear) Negative_regulation (decrease) of Positive_regulation (activation) of caspase-3
7) Confidence 0.21 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0.29 Pain Relevance 0
Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine.
Negative_regulation (attenuated) of Positive_regulation (activation) of caspase-3 associated with isoflurane
8) Confidence 0.21 Published 2008 Journal J. Neurosci. Section Title Doc Link 18434534 Disease Relevance 0.69 Pain Relevance 0.40
Memantine (20 mg/kg, i.p.) reduced isoflurane-induced caspase-3 activation in brain tissue of naive mice.
Negative_regulation (reduced) of Positive_regulation (activation) of caspase-3 in brain associated with isoflurane
9) Confidence 0.21 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18434534 Disease Relevance 0.73 Pain Relevance 0.74
Finally, PPARalpha activation reduced the lidocaine-induced caspase-3 activity and apoptosis, which might be due to the VDUP-1-mediated regulation of the Bax/Bcl-2 ratio.
Negative_regulation (reduced) of Positive_regulation (induced) of caspase-3 associated with apoptosis and lidocaine
10) Confidence 0.17 Published 2008 Journal J. Mol. Biol. Section Abstract Doc Link 18848838 Disease Relevance 0.16 Pain Relevance 0.17
Memantine (4 microM) inhibited isoflurane-induced elevations in cytosolic calcium levels and attenuated isoflurane-induced caspase-3 activation, apoptosis, and cell viability.
Negative_regulation (attenuated) of Positive_regulation (activation) of caspase-3 associated with isoflurane and apoptosis
11) Confidence 0.15 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18434534 Disease Relevance 0.74 Pain Relevance 0.73
EDTA (10 mM), BAPTA (10 microM), and RNAi silencing of IP(3) receptor, NMDA receptor, or SERCA1 attenuated caspase-3 activation.
Negative_regulation (attenuated) of Positive_regulation (activation) of caspase-3 associated with nmda receptor
12) Confidence 0.15 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18434534 Disease Relevance 0.68 Pain Relevance 0.66
Although pretreatment with zVAD completely inhibited caspase-3 activation by 3MA, it did not prevent cell death.
Negative_regulation (inhibited) of Positive_regulation (activation) of caspase-3 associated with death
13) Confidence 0.10 Published 2008 Journal Autophagy Section Abstract Doc Link 18818525 Disease Relevance 0.41 Pain Relevance 0.47
In addition, introduction of constitutively active Akt blocks caspase-3 activation and rescues cells from apoptotic death upon butyrate treatment (Fig. 4).
Negative_regulation (blocks) of Positive_regulation (activation) of caspase-3 associated with apoptosis and death
14) Confidence 0.09 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.97 Pain Relevance 0
Recent studies have shown that pharmacological activation of these kinases is associated with recruitment of anti-apoptotic signaling components such as the phosphorylation and inhibition of the proapoptotic proteins Bax and Bad, the inhibition of caspase 3 activation, the phosphorylation and activation of p70S6K (which acts to inhibit Bad) and the phosphorylation and activation of the antiapoptotic protein Bcl-2 (Harada et al 2001; Hausenloy and Yellon 2007).
Negative_regulation (inhibition) of Positive_regulation (activation) of caspase 3 associated with apoptosis
15) Confidence 0.09 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 0.42 Pain Relevance 0.09
Therefore, we hypothesize that either the bacteria use a T3SS effector protein to directly inhibit caspase-3 activation in the presence of STS, or that the bacteria indirectly block caspase-3 activation by upregulation of other pro-survival genes.
Negative_regulation (inhibit) of Positive_regulation (activation) of caspase-3
16) Confidence 0.09 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.36 Pain Relevance 0
Since S. flexneri inhibits caspase-3 activation despite cytochrome c release in the presence of STS, caspase-10 could be a eukaryotic target for the bacteria to utilize to interfere with caspase-3 activation and inhibit apoptosis.
Negative_regulation (inhibits) of Positive_regulation (activation) of caspase-3 associated with apoptosis
17) Confidence 0.09 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.31 Pain Relevance 0
More importantly, a dominant-negative form of caspase-10 is able to inhibit the activation of caspase-3 in the presence of etoposide [81].
Negative_regulation (inhibit) of Positive_regulation (activation) of caspase-3
18) Confidence 0.09 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.30 Pain Relevance 0
B and thus suppression of caspase-3 activation, of production of COX-2 and upregulation of MMPs [9].
Negative_regulation (suppression) of Positive_regulation (activation) of caspase-3 associated with metalloproteinase
19) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 1.00 Pain Relevance 0.49
B translocation to the nucleus and attenuated activation of caspase-3 and COX-2 production.
Negative_regulation (attenuated) of Positive_regulation (activation) of caspase-3 in nucleus
20) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.72 Pain Relevance 0.33

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