INT134585

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.98
Pain Relevance 6.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr2) plasma membrane (Cnr2) signal transducer activity (Cnr2)
Anatomy Link Frequency
dendrites 1
brain 1
Cnr2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 99 100.00 Very High Very High Very High
alcohol 125 99.96 Very High Very High Very High
agonist 156 99.56 Very High Very High Very High
Eae 39 99.50 Very High Very High Very High
Antinociceptive 11 99.44 Very High Very High Very High
Opioid 11 98.88 Very High Very High Very High
Pain 96 98.72 Very High Very High Very High
Cannabinoid 108 97.52 Very High Very High Very High
Lasting pain 15 97.16 Very High Very High Very High
Potency 1 94.80 High High
Disease Link Frequency Relevance Heat
Inflammatory Pain 9 99.50 Very High Very High Very High
Pain 119 98.72 Very High Very High Very High
Hyperalgesia 14 98.58 Very High Very High Very High
Targeted Disruption 34 96.72 Very High Very High Very High
Cancer 4 96.28 Very High Very High Very High
Nociception 28 96.00 Very High Very High Very High
Neuropathic Pain 75 92.32 High High
Sprains And Strains 55 92.16 High High
Anxiety Disorder 12 89.52 High High
Depression 186 80.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some CB2-R immunoreactive dendrites were seen to receive multiple synaptic contacts from axon terminals lacking CB2-R-IR (Fig. 8A).
Negative_regulation (lacking) of CB2-R-IR in dendrites
1) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.45 Pain Relevance 0.60
The absence of CB2 mRNA in CB2-R deficient mice and presence in wild type controls has also been demonstrated by others [21].
Negative_regulation (absence) of CB2-R
2) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.17 Pain Relevance 0.14
The absence of CB2 mRNA in CB2-R deficient mice and presence in wild type controls has also been demonstrated by others [21].
Negative_regulation (absence) of CB2
3) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.17 Pain Relevance 0.14
CB2-R gene targeting by CB2 antisense oligonucleotide modifies behavior
Negative_regulation (oligonucleotide) of CB2
4) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.41 Pain Relevance 0.32
They evaluated the antinociceptive actions of AM1241 and the less-selective CB2 receptor agonist WIN55,212-2 in wild-type (CB2+/+) mice and in mice with genetic disruption of the CB2 receptor (CB2-/- mice).
Negative_regulation (disruption) of CB2 associated with agonist and antinociceptive
5) Confidence 0.43 Published 2006 Journal Pain Section Abstract Doc Link 16563625 Disease Relevance 0.30 Pain Relevance 1.04
Further, recent evidence for cannabinoid-like receptors beyond CB1 and CB2 raises the possibility that AM1241 exerts its antinociceptive effects at uncharacterized CB2-like receptors that are also inhibited by AM630.
Negative_regulation (inhibited) of CB2-like associated with cannabinoid and antinociceptive
6) Confidence 0.43 Published 2006 Journal Pain Section Abstract Doc Link 16563625 Disease Relevance 0.30 Pain Relevance 0.87
The CB2 signal is markedly reduced in mouse brain when the blocking peptide is employed (data not shown).
Negative_regulation (reduced) of CB2 in brain
7) Confidence 0.39 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.04
In contrast the administration of the CB2-R antagonist AM630 reduced alcohol intake (P?
Negative_regulation (reduced) of CB2-R associated with antagonist and alcohol
8) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.06 Pain Relevance 0.59
Both display robust anti-hyperalgesic properties in rat models of inflammatory pain, which are sensitive to blockade of CB1 and CB2 receptors by SR141716 or SR144528 respectively [131,132].
Negative_regulation (blockade) of CB2 associated with hyperalgesia and eae
9) Confidence 0.18 Published 2009 Journal Mol Pain Section Body Doc Link PMC2770047 Disease Relevance 1.33 Pain Relevance 1.04
Studies have also shown CB2 selective agonists to modulate pain without central CB1-like side effects.61
Negative_regulation (shown) of CB2 associated with pain and agonist
10) Confidence 0.08 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004649 Disease Relevance 0.78 Pain Relevance 1.39

General Comments

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