INT134599

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.28
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (HSD17B2)
Anatomy Link Frequency
uterus 2
endometrium 1
HSD17B2 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 6 97.88 Very High Very High Very High
Dismenorea 6 97.28 Very High Very High Very High
agonist 1 79.52 Quite High
Inflammatory response 10 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 12 97.88 Very High Very High Very High
Dysmenorrhea 6 97.28 Very High Very High Very High
Uterine Fibroids 5 96.48 Very High Very High Very High
Disease 5 93.60 High High
Breast Cancer 2 91.96 High High
Gynecological Disease 1 75.00 Quite High
INFLAMMATION 20 5.00 Very Low Very Low Very Low
Reprotox - General 3 12 5.00 Very Low Very Low Very Low
Reprotox - General 1 8 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the data in mouse uterus suggest that it is E2-regulated, data are convincing that 17bHSD-2 in human endometrium is regulated via PR in the stroma, with paracrine factors up-regulating it in the epithelium [18].
Regulation (regulated) of 17bHSD-2 in uterus
1) Confidence 0.44 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775064 Disease Relevance 0.08 Pain Relevance 0
In a recent study by Tan et al [17], global gene profiling of mouse uterus during the estrous cycle was investigated and revealed up-regulation of 17bHSD-2 in estrus versus diestrus.
Spec (investigated) Regulation (regulation) of 17bHSD-2 in uterus
2) Confidence 0.44 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775064 Disease Relevance 0.09 Pain Relevance 0
Oestrogen metabolism, including the expression pattern of aromatase and the regulation of 17beta-hydroxysteroid dehydrogenase type 2 is altered in the eutopic endometrium of women with endometriosis, adenomyosis, and/or leiomyomas compared to that in the eutopic endometrium of women without disease.
Regulation (regulation) of 17beta-hydroxysteroid dehydrogenase type 2 in endometrium associated with endometriosis, uterine fibroids, dismenorea and disease
3) Confidence 0.07 Published 2006 Journal Best Pract Res Clin Obstet Gynaecol Section Abstract Doc Link 16564227 Disease Relevance 1.10 Pain Relevance 0.63

General Comments

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