INT134610

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 4.51
Pain Relevance 4.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) transport (Trpv1) plasma membrane (Trpv1)
transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 4
sensory neurons 2
neuronal 2
PGE2 2
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 416 100.00 Very High Very High Very High
Kinase C 26 99.96 Very High Very High Very High
Inflammation 140 99.36 Very High Very High Very High
Hyperalgesia 49 99.32 Very High Very High Very High
central sensitization 10 98.36 Very High Very High Very High
calcitonin gene related peptide 56 97.88 Very High Very High Very High
Spinal cord 52 96.96 Very High Very High Very High
TRP channel 11 94.96 High High
agonist 116 94.84 High High
dorsal root ganglion 44 94.80 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 146 99.36 Very High Very High Very High
Hyperalgesia 75 99.32 Very High Very High Very High
Nociception 128 99.28 Very High Very High Very High
Ganglion Cysts 64 94.80 High High
Injury 16 90.92 High High
Hypersensitivity 7 89.96 High High
Neuropathic Pain 57 74.12 Quite High
Pain 260 71.36 Quite High
Inflammatory Pain 23 70.48 Quite High
Targeted Disruption 82 66.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, propofol increased phosphorylation of PKCepsilon as well as TRPV1 and stimulated translocation of PKCepsilon from cytosolic to membrane fraction.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of TRPV1
1) Confidence 0.69 Published 2010 Journal Anesthesiology Section Body Doc Link 20808213 Disease Relevance 0.05 Pain Relevance 0
In line with reported sensitization of the TRPV1 in such inflammatory conditions [3,4], PKA-mediated phosphorylation of the TRPV1 occurs in neurones as well as heterologous expression systems treated with adenylate cyclase activators such as forskolin, or direct PKA activators such as 8-Br-cAMP; while PKA is also involved in PGE2- and anandamide-mediated TRPV1 sensitization as well as potentiation of capsaicin responses through the metabotropic glutamate receptor 5 [6,7,12-17].
Positive_regulation (occurs) of Phosphorylation (phosphorylation) of TRPV1 in PGE2 associated with qutenza, inflammation and glutamate receptor
2) Confidence 0.56 Published 2006 Journal Mol Pain Section Body Doc Link PMC1553434 Disease Relevance 1.01 Pain Relevance 0.81
PKC-mediated phosphorylation of TRPV1 in DRG neuronal cultures has been shown to produce faster activation and slower deactivation of the channel [4].
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of TRPV1 in neuronal
3) Confidence 0.50 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.17 Pain Relevance 0.32
PKC-dependent phosphorylation of TRPV1 not only potentiates capsaicin- or proton-evoked responses but also reduces its temperature threshold for activation [39, 126, 168, 183].
Positive_regulation (reduces) of Phosphorylation (phosphorylation) of TRPV1 associated with qutenza
4) Confidence 0.50 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.05 Pain Relevance 0.37
Since S502 is a non-specific substrate for TRPV1 phosphorylation by kinases like PKC, PKA or CAMKII, evidence for a role of PKC specific substrate S800 was investigated.
Spec (like) Positive_regulation (kinases) of Phosphorylation (phosphorylation) of TRPV1
5) Confidence 0.49 Published 2006 Journal Pain Section Abstract Doc Link 16564619 Disease Relevance 0.21 Pain Relevance 0.23
We have recently demonstrated that PKC-mediated phosphorylation of TRPV1, expressed on the central terminals of sensory neurons, activates the receptor at body temperature resulting in enhanced glutamatergic synaptic transmission [162].
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of TRPV1 in sensory neurons
6) Confidence 0.46 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.93 Pain Relevance 0.74
PKA-mediated phosphorylation of TRPV1 potentiates capsaicin-mediated current and increase CGRP release in cultured DRG neurons [64, 70, 102].
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of TRPV1 in neurons associated with calcitonin gene related peptide and qutenza
7) Confidence 0.46 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.71 Pain Relevance 0.72
The increased sensitivity to OLDA application was thus most likely mediated through TRPV1 receptors phosphorylation and/or their translocation from the cytoplasm to the presynaptic ending membrane.
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of TRPV1
8) Confidence 0.40 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2936303 Disease Relevance 0.52 Pain Relevance 0.68
PLC hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) and hydrolysis of PIP2 also releases inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), which activate PKC, leading to TRPV1 phosphorylation [83].
Positive_regulation (leading) of Phosphorylation (phosphorylation) of TRPV1 associated with kinase c
9) Confidence 0.39 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.25 Pain Relevance 0.57
Downstream of binding to its G protein-coupled receptor (GPCR), PGE2 sensitizes nociceptive neurons to thermal stimuli via PKA-dependent phosphorylation of the heat- and capsaicin-gated Transient Receptor Potential (TRP) ion channel TRPV1 [1].
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of TRPV1 in neurons associated with nociception and qutenza
10) Confidence 0.39 Published 2008 Journal Mol Pain Section Body Doc Link PMC2515828 Disease Relevance 0.60 Pain Relevance 0.31

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