INT134624

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Context Info
Confidence 0.66
First Reported 2003
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 77
Total Number 82
Disease Relevance 48.86
Pain Relevance 7.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Flt1) endosome (Flt1) Golgi apparatus (Flt1)
plasma membrane (Flt1) nucleus (Flt1) kinase activity (Flt1)
Anatomy Link Frequency
lung 6
endothelial cells 5
cochlea 4
macrophages 3
fibroblasts 3
Flt1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 399 99.84 Very High Very High Very High
Inflammation 283 99.84 Very High Very High Very High
agonist 657 99.70 Very High Very High Very High
cytokine 29 99.66 Very High Very High Very High
chemokine 16 98.56 Very High Very High Very High
ischemia 197 96.68 Very High Very High Very High
imagery 325 93.08 High High
Arthritis 59 92.52 High High
metalloproteinase 85 91.60 High High
Paracetamol 7 90.52 High High
Disease Link Frequency Relevance Heat
Hypoxia 1197 100.00 Very High Very High Very High
Targeted Disruption 183 100.00 Very High Very High Very High
Fibromyalgia 58 100.00 Very High Very High Very High
Rheumatoid Arthritis 412 99.84 Very High Very High Very High
INFLAMMATION 374 99.84 Very High Very High Very High
Pancreatic Cancer 146 99.76 Very High Very High Very High
Hypertrophy 475 99.68 Very High Very High Very High
Pre-eclampsia 688 99.40 Very High Very High Very High
Glioblastoma 31 99.40 Very High Very High Very High
Adult Respiratory Distress Syndrome 691 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Circulating VEGF as well as other growth factors produced by tumor can mobilize variety of hematopoietic cell populations that express CD45, VEGFR1, VEGFR2, VE-cadherin, tie-2 or CXC chemokine receptor 4 [52–56].
Gene_expression (express) of VEGFR1 in hematopoietic cell associated with chemokine and cancer
1) Confidence 0.66 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2902148 Disease Relevance 0.72 Pain Relevance 0.08
Increased levels of soluble VEGFR-1(s-flt) have been demonstrated to contribute to these observations (23).
Gene_expression (levels) of s-flt
2) Confidence 0.65 Published 2010 Journal American Journal of Physiology - Lung Cellular and Molecular Physiology Section Body Doc Link PMC2886605 Disease Relevance 0.71 Pain Relevance 0.04
The inhibition of corneal neovascularization was associated with suppression of Vegfr2 but not Vegfr1 expression by exogenous vasohibin-1 signaling.
Neg (not) Gene_expression (expression) of Vegfr1 associated with corneal neovascularization
3) Confidence 0.60 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2913137 Disease Relevance 0.59 Pain Relevance 0
Real-time quantitative RT–PCR was performed to determine the expression of Vegf and its receptors (Vegfr1, Vegfr2) as well as endogenous Vash1 between the treatment and control groups (Figure 5).
Spec (determine) Gene_expression (expression) of Vegfr1
4) Confidence 0.60 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2913137 Disease Relevance 0.08 Pain Relevance 0
We observed that sFlt1 and sEng were statistically higher, and PlGF was significantly lower at 26 to 30 weeks' gestation or later during pregnancy in subjects who later develop preeclampsia in some but not all of the four high-risk groups.
Gene_expression (higher) of sFlt1 associated with pre-eclampsia
5) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952583 Disease Relevance 0.73 Pain Relevance 0
Serum samples were assayed concurrently for sFlt1, sEng and PlGF using commercially available immunoassay kits purchased from R&D Systems (Minneapolis, MN).
Gene_expression (assayed) of sFlt1
6) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952583 Disease Relevance 0.59 Pain Relevance 0.04
VEGF receptor 1, 2, and 3 (VEGFR1, VEGFR2, and VEGFR3, respectively) expression increased throughout the time course, with maximal expression at 48, 8, and 72 h, respectively.
Gene_expression (expression) of VEGFR1
7) Confidence 0.53 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16565415 Disease Relevance 0.65 Pain Relevance 0.41
However, there is limited information regarding changes in these circulating factors during pregnancies of high-risk patients who later develop preeclampsia compared with similarly at risk women who do not develop preeclampsia, and the ability of measured levels of sFlt1, sEng and PlGF to predict preeclampsia in these high-risk patients.
Gene_expression (levels) of sFlt1 associated with pre-eclampsia
8) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952583 Disease Relevance 1.08 Pain Relevance 0
The maternal concentration of sFlt1 tended to be higher at 36 weeks to term among the previous preeclampsia subjects with preeclampsia (p?
Gene_expression (concentration) of sFlt1 associated with pre-eclampsia
9) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952583 Disease Relevance 1.38 Pain Relevance 0
Furthermore, Flt-1 expression levels were found to be well correlated with erythrocyte sedimentation rates, a marker of disease activity, indicating that they reflect inflammatory activity of RA [31].
Gene_expression (expression) of Flt-1 in erythrocyte associated with inflammation, rheumatoid arthritis and disease
10) Confidence 0.49 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 1.15 Pain Relevance 0.49
In addition, more recently, we found that Flt-1 is highly expressed in the sublining of leukocytes in RA synovium, and in monocytes from the PBMC of active RA patients [31].
Gene_expression (expressed) of Flt-1 in leukocytes associated with rheumatoid arthritis
11) Confidence 0.49 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 1.09 Pain Relevance 0.45
These findings suggest that chronic inflammatory milieux, such as those generated by high concentrations of proinflammatory cytokines, may upregulate Flt-1 expression on RA monocytes.
Gene_expression (expression) of Flt-1 in monocytes associated with inflammation, rheumatoid arthritis and cytokine
12) Confidence 0.49 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 1.20 Pain Relevance 0.54
Most of the vasculogenic and angiogenic effects of VEGF are mediated through the VEGF receptor 1 (VEGFR1, FLT-1) and VEGF receptor 2 (VEGFR2, Flk-1) expressed on endothelial cells [24].
Gene_expression (expressed) of VEGFR1 in endothelial cells
13) Confidence 0.49 Published 2010 Journal Angiogenesis Section Body Doc Link PMC2911541 Disease Relevance 0.23 Pain Relevance 0.33
Consistent with the marked reduction in mammary vasculature in Cox-2 null mammary tissues, the expression of several angiogenesis-associated genes was decreased (Figure 5b), including VEGF (which encodes vascular endothelial growth factor), Ang1 and Ang2 (which encode Tie-2 ligands), and Flk-1 and Flt-1 (which encode vascular endothelial growth factor receptors).
Gene_expression (expression) of Flt-1 in vasculature
14) Confidence 0.45 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 0.57 Pain Relevance 0
The present results demonstrated spiral ganglion neuron responses to EP2 and EP4 stimulation, and the expression of both Flt-1 and Flk-1 in various cochlear components including the sensory epithelium, spiral ganglion, and stria vascularis.
Gene_expression (expression) of Flt-1 in neuron associated with ganglion cysts
15) Confidence 0.43 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.42 Pain Relevance 0.08
The expression of the VEGFRs Flt-1 and Flk-1 in normal cochleae (n = 4) was examined by immunohistochemistry.
Spec (examined) Gene_expression (expression) of VEGFRs Flt-1
16) Confidence 0.43 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0 Pain Relevance 0.08
In addition, expression of the VEGFRs Flt-1 and Flk-1 was identified in the sensory epithelial cells, spiral ganglion neurons, spiral ligament fibrocytes, and stria vascularis marginal cells, which was consistent with previous findings [21].
Gene_expression (expression) of VEGFRs Flt-1 in spiral ligament associated with ganglion cysts
17) Confidence 0.43 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.25 Pain Relevance 0.14
Considering that Flt-1 tyrosine kinase signaling promotes RA via monocyte/macrophage activation [31, 40], the selective inhibition of Flt-1 may be effective at blocking VEGF-induced inflammation and angiogenesis with minimal toxicity.
Gene_expression (tyrosine kinase) of Flt-1 in macrophage associated with toxicity, inflammation and rheumatoid arthritis
18) Confidence 0.43 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 1.44 Pain Relevance 0.46
Most of the vasculogenic and angiogenic effects of VEGF are mediated through the VEGF receptor 1 (VEGFR1, FLT-1) and VEGF receptor 2 (VEGFR2, Flk-1) expressed on endothelial cells [24].
Gene_expression (expressed) of VEGFR1 in endothelial cells
19) Confidence 0.42 Published 2010 Journal Angiogenesis Section Body Doc Link PMC2911541 Disease Relevance 0.23 Pain Relevance 0.33
Decreased VEGFR-1 expression in the injured lung tissues
Gene_expression (expression) of VEGFR-1 in lung
20) Confidence 0.40 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.11 Pain Relevance 0

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