INT134625

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.71
First Reported 2006
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 116
Total Number 119
Disease Relevance 53.13
Pain Relevance 10.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Kdr) kinase activity (Kdr) cytoplasm (Kdr)
Anatomy Link Frequency
endothelial cells 12
macrophages 4
cochlea 4
fat 3
lung 3
Kdr (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 783 99.88 Very High Very High Very High
Inflammation 691 99.84 Very High Very High Very High
rheumatoid arthritis 276 99.84 Very High Very High Very High
metalloproteinase 171 99.70 Very High Very High Very High
imagery 1387 99.36 Very High Very High Very High
ischemia 268 99.04 Very High Very High Very High
chemokine 72 98.88 Very High Very High Very High
Paracetamol 14 91.60 High High
Central nervous system 32 90.32 High High
tolerance 1 87.88 High High
Disease Link Frequency Relevance Heat
Hypoxia 744 100.00 Very High Very High Very High
Fibromyalgia 51 100.00 Very High Very High Very High
Bronchitis 18 99.96 Very High Very High Very High
Hepatotoxicity 6 99.92 Very High Very High Very High
INFLAMMATION 837 99.84 Very High Very High Very High
Rheumatoid Arthritis 297 99.84 Very High Very High Very High
Cancer 3316 99.80 Very High Very High Very High
Breast Cancer 176 99.74 Very High Very High Very High
Wound Healing 149 99.66 Very High Very High Very High
Pulmonary Disease 292 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VEGF receptor 1, 2, and 3 (VEGFR1, VEGFR2, and VEGFR3, respectively) expression increased throughout the time course, with maximal expression at 48, 8, and 72 h, respectively.
Gene_expression (expression) of VEGF receptor
1) Confidence 0.71 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16565415 Disease Relevance 0.65 Pain Relevance 0.42
VEGF receptor 1, 2, and 3 (VEGFR1, VEGFR2, and VEGFR3, respectively) expression increased throughout the time course, with maximal expression at 48, 8, and 72 h, respectively.
Gene_expression (expression) of VEGFR2
2) Confidence 0.71 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16565415 Disease Relevance 0.65 Pain Relevance 0.41
We could not detect any tumors in the mice transplanted with Flk-1+ (6 × 104) cells through the 60 days after transplantation (n = 3).


Gene_expression (transplanted) of Flk-1 associated with cancer
3) Confidence 0.64 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2955572 Disease Relevance 0.31 Pain Relevance 0.04
Whereas Flk-1 expression is not endothelium-restricted [14], this result, together with the reduced vascular endothelial-cadherin (VE-Cad) expression at days 6 and 8 (Figure 5F), suggests that dorsomorphin treatment decreases endothelial cell differentiation.
Gene_expression (expression) of Flk-1 in endothelial cell associated with coronary artery disease
4) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2483414 Disease Relevance 0.10 Pain Relevance 0
Expression of Flk-1 was analyzed in primary wild-type and ?
Spec (analyzed) Gene_expression (Expression) of Flk-1
5) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
As expected, no significant changes in either mRNA or protein levels of Rac1 or Flk-1 were observed in pSico-Con infected cells (Figure 2B).
Gene_expression (levels) of Flk-1
6) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.47 Pain Relevance 0
Rac1 depletion does not affect VEGF-receptor2 expression
Gene_expression (expression) of VEGF-receptor2
7) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
The inhibition of corneal neovascularization was associated with suppression of Vegfr2 but not Vegfr1 expression by exogenous vasohibin-1 signaling.
Neg (not) Gene_expression (expression) of Vegfr2 associated with corneal neovascularization
8) Confidence 0.53 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2913137 Disease Relevance 0.59 Pain Relevance 0
Real-time quantitative RT–PCR was performed to determine the expression of Vegf and its receptors (Vegfr1, Vegfr2) as well as endogenous Vash1 between the treatment and control groups (Figure 5).
Spec (determine) Gene_expression (expression) of Vegfr2
9) Confidence 0.53 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2913137 Disease Relevance 0.08 Pain Relevance 0
This effect of anti-neovascularization may be related to the downregulation of Vegfr2 expression.



Gene_expression (expression) of Vegfr2
10) Confidence 0.53 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2913137 Disease Relevance 0.25 Pain Relevance 0
The growth of blood vessels (angiogenesis) is primarily initiated by activation of VEGFR-1 and VEGFR-2 by VEGF-A, whereas lymphangiogenesis is predominantly driven by VEGF-C, which activates VEGFR-2 and VEGFR-3 expressed in lymphatic endothelial cells.
Gene_expression (expressed) of VEGFR-2 in endothelial cells
11) Confidence 0.51 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.18 Pain Relevance 0
3-integrin can elevate VEGF-mediated responses, VEGFR2/Flk-1 levels and Flk-1 activity [12], [27] we sought to determine the effect of Rac1-depletion on Flk-1 levels in wild-type and ?
Gene_expression (levels) of Flk-1
12) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
Oligonucleotides coding shRNA for mouse Rac1, mouse VEGFR2/Flk-1, ?
Gene_expression (/) of VEGFR2
13) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
However, Rac1-depletion did not affect Flk-1 levels in either genotype (Figure 9A).
Gene_expression (levels) of Flk-1
14) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
3-null endothelial cells express higher levels of Flk-1 than wild-type controls.
Gene_expression (express) of Flk-1 in endothelial cells
15) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
3-integrin can elevate VEGF-mediated responses, VEGFR2/Flk-1 levels and Flk-1 activity [12], [27] we sought to determine the effect of Rac1-depletion on Flk-1 levels in wild-type and ?
Gene_expression (levels) of VEGFR2
16) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
A pSico containing shRNA to target the firefly Luciferase gene (pSico-Con) was generated to serve as a non-specific control RNAi and a pSico containing shRNA to target the mouse VEGFR2/Flk-1 gene (pSico-Flk-1) was made to stably knockdown the expression of Flk-1, therefore serving as a positive control in angiogenesis assays.
Gene_expression (expression) of Flk-1
17) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
3-integrin can elevate VEGF-mediated responses, VEGFR2/Flk-1 levels and Flk-1 activity [12], [27] we sought to determine the effect of Rac1-depletion on Flk-1 levels in wild-type and ?
Gene_expression (levels) of Flk-1
18) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
We show that VEGF/VEGFR2-mediated responses are Rac1-dependent in the absence, but not in the presence of ?
Gene_expression (/) of VEGFR2
19) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.29 Pain Relevance 0
Oligonucleotides coding shRNA for mouse Rac1, mouse VEGFR2/Flk-1, ?
Gene_expression (/) of Flk-1
20) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox