INT134626

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Context Info
Confidence 0.63
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 14.63
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Kdr) kinase activity (Kdr) cytoplasm (Kdr)
Anatomy Link Frequency
fat 4
epithelial cell 4
heart 4
endothelial cells 2
neuron 2
Kdr (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 16 99.32 Very High Very High Very High
imagery 418 98.96 Very High Very High Very High
Paracetamol 14 91.60 High High
Central nervous system 6 91.16 High High
Inflammation 118 90.76 High High
tolerance 1 88.44 High High
antagonist 40 83.40 Quite High
Inflammatory response 28 73.20 Quite High
Kinase C 2 72.84 Quite High
metalloproteinase 33 68.20 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 226 100.00 Very High Very High Very High
Bronchitis 9 99.96 Very High Very High Very High
Hepatotoxicity 6 99.92 Very High Very High Very High
Cancer 521 99.80 Very High Very High Very High
Wound Healing 16 99.66 Very High Very High Very High
Injury 58 99.60 Very High Very High Very High
Ganglion Cysts 17 99.34 Very High Very High Very High
Cv Unclassified Under Development 15 99.32 Very High Very High Very High
Apoptosis 135 98.90 Very High Very High Very High
Malignant Neoplastic Disease 11 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VEGF receptor 1, 2, and 3 (VEGFR1, VEGFR2, and VEGFR3, respectively) expression increased throughout the time course, with maximal expression at 48, 8, and 72 h, respectively.
Positive_regulation (increased) of Gene_expression (expression) of VEGFR2
1) Confidence 0.63 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16565415 Disease Relevance 0.65 Pain Relevance 0.41
VEGF receptor 1, 2, and 3 (VEGFR1, VEGFR2, and VEGFR3, respectively) expression increased throughout the time course, with maximal expression at 48, 8, and 72 h, respectively.
Positive_regulation (increased) of Gene_expression (expression) of VEGF receptor
2) Confidence 0.46 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16565415 Disease Relevance 0.66 Pain Relevance 0.42
Mice were imaged at week 2 and week 4 both FLI (a) and BLI (b) using the IVIS Spectrum (Caliper LifeSciences, USA) camera system. a Tumor growth of the mCherry positive tumor could be followed over time using FLI. b The BLI signal was present at the site of both the mCherry positive and negative tumors indicating a local upregulation of VEGFR2 expression and tumor angiogenesis.
Positive_regulation (upregulation) of Gene_expression (expression) of VEGFR2 associated with cancer and imagery
3) Confidence 0.42 Published 2010 Journal Angiogenesis Section Body Doc Link PMC2911541 Disease Relevance 1.28 Pain Relevance 0.31
During angiogenesis, including tumor angiogenesis, both VEGF and VEGFR2 expression are locally upregulated [25–28].
Positive_regulation (upregulated) of Gene_expression (expression) of VEGFR2 associated with cancer
4) Confidence 0.42 Published 2010 Journal Angiogenesis Section Body Doc Link PMC2911541 Disease Relevance 0.25 Pain Relevance 0.24
The VEGFR2-luc mouse has been validated using cutaneous wound healing models in which VEGFR2 expression was upregulated at the site of a punch wound marked by a clear localized increase of the luciferase signal.
Positive_regulation (upregulated) of Gene_expression (expression) of VEGFR2 associated with injury and wound healing
5) Confidence 0.42 Published 2010 Journal Angiogenesis Section Body Doc Link PMC2911541 Disease Relevance 0.76 Pain Relevance 0.14
The fluorescent signal from the SMF-mCherry cells and bioluminescent signal from the locally upregulated VEGFR2 expression enabled the simultaneous imaging and quantification of angiogenesis and tumor growth real time in vivo.
Positive_regulation (upregulated) of Gene_expression (expression) of VEGFR2 associated with cancer and imagery
6) Confidence 0.42 Published 2010 Journal Angiogenesis Section Body Doc Link PMC2911541 Disease Relevance 1.30 Pain Relevance 0.25
Local tissue ischemia, due to endothelial dysfunction, increases the production of proangiogenic substances such as vascular endothelial growth factor (VEGF), angiogenin, VEGF receptor-2 (KDR), paralleled by decrease of the inhibitors of angiogenesis such as Pigment Epithelium Derived Factor (PEDF) result in retinal neovascularization as well as microangiopathy [5,6].
Positive_regulation (increases) of Gene_expression (production) of KDR in Epithelium associated with ischemia and retinal neovascularization
7) Confidence 0.33 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 1.83 Pain Relevance 0.21
The growth of blood vessels (angiogenesis) is primarily initiated by activation of VEGFR-1 and VEGFR-2 by VEGF-A, whereas lymphangiogenesis is predominantly driven by VEGF-C, which activates VEGFR-2 and VEGFR-3 expressed in lymphatic endothelial cells.
Positive_regulation (activates) of Gene_expression (expressed) of VEGFR-2 in endothelial cells
8) Confidence 0.33 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.19 Pain Relevance 0
A second mechanism of TK dysfunction in malignant cells is via the overexpression of a TK or its ligand; eg, the overexpression of VEGFR, PDGFR, or EGFR or their ligands in RCC (Gomella et al 1989; Mydlo et al 1989; Atlas et al 1992; Uhlman et al 1995; Iliopoulos et al 1996; Ramp et al 2000; Gunningham et al 2001; Na et al 2003; Sulzbacher et al 2003, Yildiz et al 2004; Minardi et al 2005; Xu et al 2005).
Positive_regulation (overexpression) of Gene_expression (overexpression) of VEGFR in Atlas associated with malignant neoplastic disease and renal cell carcinoma
9) Confidence 0.23 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.67 Pain Relevance 0.04
The present results demonstrated spiral ganglion neuron responses to EP2 and EP4 stimulation, and the expression of both Flt-1 and Flk-1 in various cochlear components including the sensory epithelium, spiral ganglion, and stria vascularis.
Positive_regulation (stimulation) of Gene_expression (expression) of Flk-1 in neuron associated with ganglion cysts
10) Confidence 0.16 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.42 Pain Relevance 0.08
Indeed, the increased VEGFR-2 expression in the EPO-treated fat grafts that was observed in our study implies that EPO-induced endogenous VEGF secretion in the fat grafts might be more effective than exogenous VEGF administration.
Positive_regulation (increased) of Gene_expression (expression) of VEGFR-2 in fat
11) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.41 Pain Relevance 0.03
In addition, in patients with emphysema for example, inhibitors of apoptosis are needed whereas in contrast to chronic bronchitis, expression of hypoxia-inducible factor, VEGF, and VEGFR2 may be stimulated to overcome endothelial and epithelial cell death and improve vascular restoration (Voelkel and Coll 2003).
Positive_regulation (stimulated) of Gene_expression (expression) of VEGFR2 in epithelial cell associated with emphysema, hypoxia, bronchitis, apoptosis and death
12) Confidence 0.13 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.58 Pain Relevance 0.13
Animal test showed that the expression of Flk-1 (VEGFR-2) is elevated in ?
Positive_regulation (elevated) of Gene_expression (expression) of VEGFR-2
13) Confidence 0.13 Published 2008 Journal Perspectives in Medicinal Chemistry Section Body Doc Link PMC2746574 Disease Relevance 0.34 Pain Relevance 0
Expression of endothelial genes such as Flk-1, Kit, Pdgfra and Tek was also increased with increased immunoreactivity against the gene products (fig. 3g).
Positive_regulation (increased) of Gene_expression (Expression) of Flk-1
14) Confidence 0.12 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0.23 Pain Relevance 0
Indeed, the increased VEGFR-2 expression in the EPO-treated fat grafts that was observed in our study implies that EPO-induced endogenous VEGF secretion in the fat grafts might be more effective than exogenous VEGF administration.
Positive_regulation (induced) of Gene_expression (expression) of VEGFR-2 in fat
15) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.42 Pain Relevance 0.03
Unlike the non-hypertrophied heart, hypoxia further increased VEGF-1 expression without a concomitant increase in the pro-angiogenic receptor, VEGFR-2.
Positive_regulation (increased) of Gene_expression (expression) of VEGFR in heart associated with hypoxia
16) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603310 Disease Relevance 0.59 Pain Relevance 0
Unlike the non-hypertrophied heart, hypoxia further increased VEGF-1 expression without a concomitant increase in the pro-angiogenic receptor, VEGFR-2.
Neg (without) Positive_regulation (increase) of Gene_expression (expression) of VEGFR in heart associated with hypoxia
17) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603310 Disease Relevance 0.58 Pain Relevance 0
On the other hand, a significant increase of VEGFR-2 expression under hypoxia was detected in animals of the sham-operated group.
Positive_regulation (increase) of Gene_expression (expression) of VEGFR associated with hypoxia
18) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603310 Disease Relevance 0.80 Pain Relevance 0
The increased expressions of VEGF and VEGFR correlated with the rate of SEC proliferation after PH [40].
Positive_regulation (increased) of Gene_expression (expressions) of VEGFR
19) Confidence 0.09 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2933582 Disease Relevance 0.59 Pain Relevance 0
We also observed Flk-1 and CD133 were expressed at high level on undifferentiated hESCs (Figure S1), consistent with previous reports [10], [12]. hESC-ECs morphologically resembled HUVECs, which were uniformly flat, adherent, and cobblestone-like in appearance.
Positive_regulation (level) of Gene_expression (expressed) of Flk-1
20) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0

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