INT134627

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 7.16
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Flt1) endosome (Flt1) Golgi apparatus (Flt1)
plasma membrane (Flt1) nucleus (Flt1) kinase activity (Flt1)
Anatomy Link Frequency
hearts 4
monocytes 2
neuron 2
lung 2
Flt1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2 99.88 Very High Very High Very High
rheumatoid arthritis 57 99.84 Very High Very High Very High
Inflammation 27 98.18 Very High Very High Very High
Central nervous system 2 91.16 High High
Paracetamol 7 90.52 High High
fibrosis 1 86.24 High High
ischemia 20 80.68 Quite High
Arthritis 8 50.00 Quite Low
agonist 54 18.56 Low Low
anesthesia 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 58 99.84 Very High Very High Very High
Hypertrophy 100 99.70 Very High Very High Very High
Pre-eclampsia 136 99.40 Very High Very High Very High
Hypoxia 239 99.38 Very High Very High Very High
Ganglion Cysts 17 99.34 Very High Very High Very High
Adult Respiratory Distress Syndrome 79 99.32 Very High Very High Very High
Hepatotoxicity 3 98.84 Very High Very High Very High
INFLAMMATION 35 98.18 Very High Very High Very High
Toxicity 5 94.88 High High
Disease 17 91.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased levels of soluble VEGFR-1(s-flt) have been demonstrated to contribute to these observations (23).
Positive_regulation (Increased) of Gene_expression (levels) of s-flt
1) Confidence 0.49 Published 2010 Journal American Journal of Physiology - Lung Cellular and Molecular Physiology Section Body Doc Link PMC2886605 Disease Relevance 0.71 Pain Relevance 0.04
These findings suggest that chronic inflammatory milieux, such as those generated by high concentrations of proinflammatory cytokines, may upregulate Flt-1 expression on RA monocytes.
Spec (may) Positive_regulation (upregulate) of Gene_expression (expression) of Flt-1 in monocytes associated with inflammation, rheumatoid arthritis and cytokine
2) Confidence 0.44 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 1.20 Pain Relevance 0.54
The maternal concentration of sFlt1 tended to be higher at 36 weeks to term among the previous preeclampsia subjects with preeclampsia (p?
Positive_regulation (tended) of Gene_expression (concentration) of sFlt1 associated with pre-eclampsia
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952583 Disease Relevance 1.39 Pain Relevance 0
VEGF receptor 1, 2, and 3 (VEGFR1, VEGFR2, and VEGFR3, respectively) expression increased throughout the time course, with maximal expression at 48, 8, and 72 h, respectively.
Positive_regulation (increased) of Gene_expression (expression) of VEGFR1
4) Confidence 0.34 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16565415 Disease Relevance 0.65 Pain Relevance 0.41
The present results demonstrated spiral ganglion neuron responses to EP2 and EP4 stimulation, and the expression of both Flt-1 and Flk-1 in various cochlear components including the sensory epithelium, spiral ganglion, and stria vascularis.
Positive_regulation (stimulation) of Gene_expression (expression) of Flt-1 in neuron associated with ganglion cysts
5) Confidence 0.28 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.42 Pain Relevance 0.08
We observed an increase of VEGF in the BAL, a decreased expression of VEGF and VEGFR-1, and an altered expression pattern of VEGFR-2 in the lung tissue.
Positive_regulation (increase) of Gene_expression (expression) of VEGFR-1 in lung
6) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.39 Pain Relevance 0
and VEGFR-1 are preserved during hypertrophy, which results in increased expression of VEGFR-1 in hearts that are both hypoxic and hypertrophied.
Positive_regulation (increased) of Gene_expression (expression) of VEGFR-1 in hearts associated with hypertrophy and hypoxia
7) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603310 Disease Relevance 1.29 Pain Relevance 0.04
In hearts subjected to both hypoxia and hypertrophy (BAND HYPOX), increased expression of VEGFR-1 was much more pronounced.
Positive_regulation (increased) of Gene_expression (expression) of VEGFR-1 in hearts associated with hypertrophy and hypoxia
8) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603310 Disease Relevance 0.86 Pain Relevance 0
Based on this information, excessive expression of VEGFR-1 could result in increased binding to VEGF ligand, resulting in competitive suppression of VEFGR-2 activation and the angiogenic response.
Positive_regulation (result) of Gene_expression (expression) of VEGFR-1
9) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603310 Disease Relevance 0 Pain Relevance 0
Interestingly, Ahmad et al. showed that elevated expression of soluble VEGFR-1 in the inhibits placental angiogenesis [40], a result that is consistent with our observations.
Positive_regulation (elevated) of Gene_expression (expression) of VEGFR-1
10) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603310 Disease Relevance 0.23 Pain Relevance 0

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