INT134628

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 7.52
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Flt4) nucleus (Flt4) kinase activity (Flt4)
cytoplasm (Flt4)
Anatomy Link Frequency
endothelial cells 2
corneal epithelium 2
Flt4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 35 98.66 Very High Very High Very High
Inflammation 105 98.46 Very High Very High Very High
cINOD 90 97.50 Very High Very High Very High
Paracetamol 7 89.72 High High
Inflammatory response 6 87.96 High High
Inflammatory mediators 9 75.88 Quite High
chemokine 12 67.00 Quite High
antagonist 6 30.16 Quite Low
cva 2 27.44 Quite Low
imagery 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 392 99.98 Very High Very High Very High
Disease 23 98.76 Very High Very High Very High
INFLAMMATION 123 98.46 Very High Very High Very High
Hepatotoxicity 3 98.04 Very High Very High Very High
Metastasis 195 97.80 Very High Very High Very High
Carcinoma 36 97.44 Very High Very High Very High
Toxicity 4 94.08 High High
Lymphedema 135 92.00 High High
Adenocarcinoma 6 87.96 High High
Breast Cancer 18 87.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VEGF receptor 1, 2, and 3 (VEGFR1, VEGFR2, and VEGFR3, respectively) expression increased throughout the time course, with maximal expression at 48, 8, and 72 h, respectively.
Gene_expression (expression) of VEGFR3
1) Confidence 0.48 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16565415 Disease Relevance 0.65 Pain Relevance 0.41
VEGFR-3 has been shown to be expressed in corneal epithelium [15] and corneal dendritic cells [16], and VEGFR-3 expression is upregulated in inflamed corneas [17].
Gene_expression (expressed) of VEGFR-3 in corneal epithelium
2) Confidence 0.41 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994732 Disease Relevance 0.22 Pain Relevance 0.07
VEGFR-3 has been shown to be expressed in corneal epithelium [15] and corneal dendritic cells [16], and VEGFR-3 expression is upregulated in inflamed corneas [17].
Gene_expression (expression) of VEGFR-3 in corneal epithelium
3) Confidence 0.41 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994732 Disease Relevance 0.29 Pain Relevance 0.10
The NSAID-induced up-regulation of these pro-inflammatory cytokines was accompanied by significant, parallel up-regulation of VEGF-C, VEGFR-3, and Prox1 expression.
Gene_expression (expression) of VEGFR-3 associated with inflammation, cinod and cytokine
4) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791214 Disease Relevance 0.64 Pain Relevance 0.65
The growth of blood vessels (angiogenesis) is primarily initiated by activation of VEGFR-1 and VEGFR-2 by VEGF-A, whereas lymphangiogenesis is predominantly driven by VEGF-C, which activates VEGFR-2 and VEGFR-3 expressed in lymphatic endothelial cells.
Gene_expression (expressed) of VEGFR-3 in endothelial cells
5) Confidence 0.32 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.18 Pain Relevance 0
In addition, VEGFR-3, the VEGF-C receptor, is predominantly expressed on lymphatic endothelial cells [29], and VEGF-C-dependent activation of VEGFR-3 stimulates the growth of lymphatic endothelial cells and lymphatics [30].
Gene_expression (expressed) of VEGFR-3 in endothelial cells
6) Confidence 0.32 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.81 Pain Relevance 0
by sTNF-R1 decreased VEGF-C and VEGFR-3 transcription and expression and correlated with increased disease severity.
Gene_expression (expression) of VEGFR-3 associated with disease
7) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791214 Disease Relevance 0.62 Pain Relevance 0.12
This cell line and inoculated tumors expressed VEGF-C and VEGFR-3 [21].
Gene_expression (expressed) of VEGFR-3 associated with cancer
8) Confidence 0.25 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 0.59 Pain Relevance 0
Immunohistochemically the tumor cells are positive for Von-Willebrand factor, CD31, CD34 and vascular endothelial growth factor receptor-3 (VEGFR-3).
Gene_expression (positive) of vascular endothelial growth factor receptor-3 associated with cancer
9) Confidence 0.16 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1555613 Disease Relevance 0.84 Pain Relevance 0
mRNA and protein levels correlated with increased expression of the pro-lymphangiogenic factor VEGF-C and its cognate receptor, VEGFR-3.
Gene_expression (expression) of VEGFR-3
10) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791214 Disease Relevance 0.69 Pain Relevance 0.58

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