INT134629

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Context Info
Confidence 0.32
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.13
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Flt4) nucleus (Flt4) kinase activity (Flt4)
cytoplasm (Flt4)
Anatomy Link Frequency
endothelial cells 2
corneal epithelium 2
Flt4 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 7 89.72 High High
Inflammation 6 88.96 High High
cytokine 1 67.20 Quite High
imagery 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 3 98.04 Very High Very High Very High
Toxicity 4 94.08 High High
INFLAMMATION 6 88.96 High High
Metastasis 64 88.16 High High
Cancer 120 85.44 High High
Organ Transplantation 6 82.56 Quite High
Lymphatic Metastasis 3 75.20 Quite High
Hyperplasia 2 68.32 Quite High
Breast Cancer 6 68.00 Quite High
Adhesions 2 63.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VEGFR-3 has been shown to be expressed in corneal epithelium [15] and corneal dendritic cells [16], and VEGFR-3 expression is upregulated in inflamed corneas [17].
Positive_regulation (upregulated) of Gene_expression (expression) of VEGFR-3 in corneal epithelium
1) Confidence 0.32 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994732 Disease Relevance 0.29 Pain Relevance 0.11
VEGF receptor 1, 2, and 3 (VEGFR1, VEGFR2, and VEGFR3, respectively) expression increased throughout the time course, with maximal expression at 48, 8, and 72 h, respectively.
Positive_regulation (increased) of Gene_expression (expression) of VEGFR3
2) Confidence 0.31 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16565415 Disease Relevance 0.65 Pain Relevance 0.41
The growth of blood vessels (angiogenesis) is primarily initiated by activation of VEGFR-1 and VEGFR-2 by VEGF-A, whereas lymphangiogenesis is predominantly driven by VEGF-C, which activates VEGFR-2 and VEGFR-3 expressed in lymphatic endothelial cells.
Positive_regulation (activates) of Gene_expression (expressed) of VEGFR-3 in endothelial cells
3) Confidence 0.21 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.19 Pain Relevance 0

General Comments

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