INT134629

Context Info Confidence 0.32 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 2.13 Pain Relevance 0.52

plasma membrane (Flt4) nucleus (Flt4) kinase activity (Flt4) cytoplasm (Flt4)

Anatomy Link Frequency endothelial cells 2 corneal epithelium 2 Flt4 (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 7 89.72 Inflammation 6 88.96 cytokine 1 67.20 imagery 6 5.00 anesthesia 4 5.00 isoflurane 3 5.00 antagonist 2 5.00 ketamine 1 5.00

Disease Link Frequency Relevance Heat Hepatotoxicity 3 98.04 Toxicity 4 94.08 INFLAMMATION 6 88.96 Metastasis 64 88.16 Cancer 120 85.44 Organ Transplantation 6 82.56 Lymphatic Metastasis 3 75.20 Hyperplasia 2 68.32 Breast Cancer 6 68.00 Adhesions 2 63.20

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

VEGFR-3 has been shown to be expressed in corneal epithelium [15] and corneal dendritic cells [16], and VEGFR-3 expression is upregulated in inflamed corneas [17].

Positive_regulation (upregulated) of Gene_expression (expression) of VEGFR-3 in corneal epithelium

1) Confidence 0.32 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994732 Disease Relevance 0.29 Pain Relevance 0.11

VEGF receptor 1, 2, and 3 (VEGFR1, VEGFR2, and VEGFR3, respectively) expression increased throughout the time course, with maximal expression at 48, 8, and 72 h, respectively.

Positive_regulation (increased) of Gene_expression (expression) of VEGFR3

2) Confidence 0.31 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16565415 Disease Relevance 0.65 Pain Relevance 0.41

The growth of blood vessels (angiogenesis) is primarily initiated by activation of VEGFR-1 and VEGFR-2 by VEGF-A, whereas lymphangiogenesis is predominantly driven by VEGF-C, which activates VEGFR-2 and VEGFR-3 expressed in lymphatic endothelial cells.

Positive_regulation (activates) of Gene_expression (expressed) of VEGFR-3 in endothelial cells

3) Confidence 0.21 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.19 Pain Relevance 0

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