INT134633

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 6.39
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adipoq) extracellular region (Adipoq) endoplasmic reticulum (Adipoq)
Anatomy Link Frequency
adipose tissue 3
plasma 1
liver 1
skeletal muscle 1
adipocytes 1
Adipoq (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 37 98.36 Very High Very High Very High
Angina 8 98.36 Very High Very High Very High
Migraine 11 95.72 Very High Very High Very High
Calcitonin gene-related peptide 1 90.52 High High
agonist 52 87.72 High High
cytokine 7 86.60 High High
Neuropeptide 1 86.04 High High
depression 1 83.44 Quite High
headache 1 76.20 Quite High
anesthesia 4 74.24 Quite High
Disease Link Frequency Relevance Heat
Obesity 98 100.00 Very High Very High Very High
Variant Angina Pectoris 5 98.68 Very High Very High Very High
Metabolic Syndrome 19 98.56 Very High Very High Very High
INFLAMMATION 63 98.36 Very High Very High Very High
Increased Venous Pressure Under Development 5 98.12 Very High Very High Very High
Insulin Resistance 39 97.96 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

5 96.48 Very High Very High Very High
Headache 12 95.72 Very High Very High Very High
Coronary Artery Disease 3 95.72 Very High Very High Very High
Acute Coronary Syndrome 2 93.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also examined levels of adipokines such as leptin and adiponectin, which are hormones secreted by adipose tissue.
Localization (secreted) of adiponectin in adipose tissue associated with obesity
1) Confidence 0.60 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2867220 Disease Relevance 0.32 Pain Relevance 0
Determination of serum adiponectin
Localization (Determination) of serum adiponectin
2) Confidence 0.59 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.16 Pain Relevance 0.19
Decrease in plasma adiponectin concentrations in patients with variant angina pectoris.
Localization (Decrease) of plasma adiponectin in plasma associated with angina and variant angina pectoris
3) Confidence 0.58 Published 2006 Journal Circ. J. Section Title Doc Link 16565557 Disease Relevance 0.64 Pain Relevance 0.44
Acrp30 is expressed exclusively in the adipocytes, its hormone is exclusively secreted by differentiated adipocytes [42], and its protein was secreted and detected in plasma [43].
Localization (secreted) of Acrp30 in adipocytes associated with obesity
4) Confidence 0.56 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0.20 Pain Relevance 0
Adiponectin is an adipose tissue-secreted endogenous insulin sensitizer, which plays a key role as a mediator of peroxisome proliferator-activated receptor gamma action.
Localization (secreted) of Adiponectin in adipose tissue associated with obesity
5) Confidence 0.56 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2867220 Disease Relevance 0.53 Pain Relevance 0
Further conclusions are that decreased adiponectin action and increased monocyte chemoattractant protein-1 (MCP-1) form a vicious adipokine network causing obesity-linked insulin resistance and metabolic syndrome; PPARgamma upregulates HMW adiponectin and PPARalpha upregulates AdipoRs; that dietary osmotin can serve as a naturally occurring adiponectin receptor agonist; and finally, that under starvation conditions, MMW adiponectin activates AMPK in hypothalamus, and promotes food intake, and at the same time HMW adiponectin activates AMPK in peripheral tissues, such as skeletal muscle, and stimulates fatty-acids combustion.
Localization (action) of adiponectin in skeletal muscle associated with starvation, agonist, metabolic syndrome and insulin resistance
6) Confidence 0.42 Published 2008 Journal Int J Obes (Lond) Section Abstract Doc Link 19136982 Disease Relevance 0.94 Pain Relevance 0.09
We have found that decreased high molecular weight (HMW) adiponectin plays a crucial and causal role in obesity-linked insulin resistance and metabolic syndrome; that AdipoR1 and AdipoR2 serve as the major AdipoRs in vivo; and that AdipoR1 activates the AMP kinase (AMPK) pathway and AdipoR2, the peroxisome proliferator-activated receptor alpha (PPARalpha) pathway in the liver, to increase insulin sensitivity and decrease inflammation.
Localization (decreased) of adiponectin in liver associated with inflammation, metabolic syndrome and insulin resistance
7) Confidence 0.37 Published 2008 Journal Int J Obes (Lond) Section Abstract Doc Link 19136982 Disease Relevance 0.79 Pain Relevance 0.04
Serum samples were analyzed to determine the presence of adiponectin.
Spec (determine) Localization (presence) of adiponectin
8) Confidence 0.22 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817554 Disease Relevance 0.73 Pain Relevance 0.11
Similarly, adiponectin, an adipocytokine secreted by adipose tissue, has protective roles against the development of insulin resistance, dyslipidaemia and atherosclerosis and exhibits anti-inflammatory properties.
Localization (secreted) of adiponectin in adipose tissue associated with inflammation, obesity, increased venous pressure under development and insulin resistance
9) Confidence 0.15 Published 2007 Journal Cephalalgia Section Abstract Doc Link 17448181 Disease Relevance 1.72 Pain Relevance 1.01
, IL-6, sCD40L, IL-8, MMP-9, TIMP-1, IL-18, and adiponectin.
Spec (determination) Localization (sCD40L) of adiponectin
10) Confidence 0.09 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940874 Disease Relevance 0.26 Pain Relevance 0.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox