INT134646

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 14.77
Pain Relevance 4.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tnfsf11) extracellular space (Tnfsf11) extracellular region (Tnfsf11)
plasma membrane (Tnfsf11) intracellular (Tnfsf11) response to stress (Tnfsf11)
Anatomy Link Frequency
osteoclast 2
Macrophage 1
joint 1
Nerve 1
osteoblasts 1
Tnfsf11 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 74 99.92 Very High Very High Very High
Nerve growth factor 15 99.72 Very High Very High Very High
Arthritis 521 99.30 Very High Very High Very High
rheumatoid arthritis 59 98.86 Very High Very High Very High
metalloproteinase 2 98.54 Very High Very High Very High
fluoxetine 33 97.58 Very High Very High Very High
Rheumatism 3 97.24 Very High Very High Very High
adenocard 21 96.12 Very High Very High Very High
psoriasis 95 94.24 High High
Somatostatin 6 93.36 High High
Disease Link Frequency Relevance Heat
Cancer 83 100.00 Very High Very High Very High
Necrosis 53 100.00 Very High Very High Very High
Respiratory Syncytial Virus 232 99.42 Very High Very High Very High
Seronegative Spondarthritis 337 99.30 Very High Very High Very High
Rheumatoid Arthritis 69 98.86 Very High Very High Very High
Disease 111 98.44 Very High Very High Very High
Bone Cancer 41 98.24 Very High Very High Very High
Hypercalcemia 75 97.90 Very High Very High Very High
Rheumatic Diseases 3 97.24 Very High Very High Very High
Low Back Pain 28 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, our study is the first to report that HEP extract stimulated the expression of OPG mRNA but suppressed the expression of RANKL mRNA in the UMR 106 cell line, resulting in a dose-dependent increase in the OPG/RANKL ratio.
Gene_expression (expression) of RANKL mRNA
1) Confidence 0.69 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193542 Disease Relevance 0.24 Pain Relevance 0
On the other hand, the expression of RANKL mRNA in these cells was significantly downregulated by treatment with 200 ?
Gene_expression (expression) of RANKL mRNA
2) Confidence 0.69 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193542 Disease Relevance 0.35 Pain Relevance 0
Thus, the osteoblasts and the bone marrow stromal cells produce RANKL which activates the osteoclasts by binding to its RANK receptor.
Gene_expression (produce) of RANKL in bone marrow
3) Confidence 0.69 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.48 Pain Relevance 0
This was based on its potent stimulation of bone resorption in tissue cultures [10,11] which was further substantiated by the finding that 1,25(OH)2D increased the RANKL expression [5,11].
Gene_expression (expression) of RANKL associated with hypercalcemia
4) Confidence 0.69 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.37 Pain Relevance 0
Although 1,25(OH)2D has been demonstrated in in-vitro studies to increase RANKL expression [5] and reduce the OPG expression [9], supplementation with vitamin D in our study did not significantly affect their serum levels.
Gene_expression (expression) of RANKL
5) Confidence 0.69 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.17 Pain Relevance 0.03
Overproduction of RANKL is implicated in a variety of degenerative bone diseases, including rheumatism [16].
Gene_expression (Overproduction) of RANKL associated with rheumatism and bone cancer
6) Confidence 0.66 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 0.73 Pain Relevance 0.50
Most likely oestrogen, as well as bisphosphonates, influence the production of OPG and RANKL as demonstrated in in-vitro studies [32,33].
Gene_expression (production) of RANKL
7) Confidence 0.60 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.28 Pain Relevance 0.05
Therefore, the lack of corresponding changes in serum levels indicate that the circulating levels of OPG and RANKL do not reflect the concentrations in the local tissues [27].
Gene_expression (levels) of RANKL
8) Confidence 0.60 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.26 Pain Relevance 0.04
Treatment with fluoxetine resulted in up-regulation of five (Glial cell line derived neurotrophic factor superfamily receptor alpha 2, Macrophage expressed gene 1, Tumor necrosis factor member 11, Activity-dependent neuroprotective protein, Fyn proto-oncogene), 15 (Nerve growth factor beta, Midkine, Type 1 tumor necrosis factor receptor regulator, Jun D proto-oncogene, Adenosine A1 receptor, Neurotrophic tyrosine kinase, receptor type 2, Somatostatin receptor 5, Leptin receptor, Adrenomedullin, Arrestin beta 1, Epsin 1, Caspase 8, Cyclin-dependent kinase 5, Synuclein alpha, Amyloid beta precursor protein) and four (Transforming growth factor beta 2, Growth differentiation factor 15, RAB6A, Syntaxin 11) genes and downregulation of three (Immunoglobulin superfamily member 6, Secreted phosphoprotein 1, Tumor necrosis factor receptor superfamily member 6), four (Serum amyloid A 4, Angiopoietin 1, Apoptosis facilitator Bcl-2-like protein 14, Interferon gamma) and two (Tumor necrosis factor alpha induced protein 6, Granzyme A ) genes after 1, 3, and 7 days, respectively.
Gene_expression (expressed) of Tumor necrosis factor member 11 in Macrophage associated with necrosis, adenocard, nerve growth factor, cancer, alzheimer's dementia, somatostatin, apoptosis and fluoxetine
9) Confidence 0.51 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 1.47 Pain Relevance 0.37
Treatment with imipramine resulted in significant up-regulation of three (Glial cell line derived neurotrophic factor superfamily receptor alpha 2, Macrophage expressed gene 1, Tumor necrosis factor member 11), 13 (Nerve growth factor beta, tumor necrosis factor receptor regulator, Jun D proto-oncogene, Adenosine A1 receptor, Neurotrophic tyrosine kinase receptor type 2, Somatostatin receptor 5, Leptin receptor, Arrestin beta 1, Epsin 1, Caspase 8, Cyclin-dependent kinase 5, Synuclein alpha, Amyloid beta precursor protein), and five (Transforming growth factor beta 2, RAB6A member RAS oncogene family, Regucalcin, Syntaxin 11, Homogentisate 1, 2-dioxygenase) genes and down-regulation of five (Leukocyte cell derived chemotaxin 1, Phospholipase A2 activating protein, Mitogen-activated protein kinase), one (Interferon gamma), and two (Tumor necrosis factor alpha induced protein 6, Granzyme A) genes after one, three and seven days of treatment, respectively.
Gene_expression (expressed) of Tumor necrosis factor member 11 in Nerve associated with necrosis, adenocard, nerve growth factor, cancer, alzheimer's dementia and somatostatin
10) Confidence 0.45 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 1.34 Pain Relevance 0.22
One-hour or 7-day treatment with PDM02 suppressed RANKL-induced nuclear translocation of NF-?
Gene_expression (suppressed) of RANKL
11) Confidence 0.29 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.44 Pain Relevance 0
We showed that short treatment with RSV analogues (30 minutes after exposure to RANKL), even at 10 nM, significantly diminished nuclear translocation of NF-?
Gene_expression (exposure) of RANKL associated with respiratory syncytial virus
12) Confidence 0.25 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.90 Pain Relevance 0
Intense RANKL expression has been demonstrated within the lining layer in the PsA joint, with more restricted sublining layer OPG expression, implicating imbalance in the RANKL/OPG axis that, in turn, may promote osteoclastogenesis [12].
Gene_expression (expression) of RANKL in joint associated with arthritis
13) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945067 Disease Relevance 0.81 Pain Relevance 0.26
However, it should be noted that both M-CSF and RANKL were added to the osteoclast-differentiation cultures; thus, a biologic effect of M-CSF on osteoclast development or activity in vivo cannot be excluded entirely.
Gene_expression (added) of RANKL in osteoclast
14) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945067 Disease Relevance 0.68 Pain Relevance 0.24
IL-17 also induces the expression of matrix metalloproteinase-1 and -13 in RA synovial cells and osteoblasts [15,16], and induces the expression of RANKL (receptor activator of nuclear factor-?
Gene_expression (expression) of RANKL in osteoblasts associated with rheumatoid arthritis and metalloproteinase
15) Confidence 0.15 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 1.48 Pain Relevance 0.62
The soluble factors analyzed in this study are key regulators of bone turnover, and our data suggest that systemic expression of factors promoting osteoclastogenesis and bone loss (Dkk-1, M-CSF, RANKL) is disordered in patients with PsA.
Gene_expression (expression) of RANKL associated with arthritis
16) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945067 Disease Relevance 0.74 Pain Relevance 0.30
Large numbers of spontaneously arising bone-resorbing osteoclast-like cells were not observed in patients with PsA or in control participants in the absence of RANKL and M-CSF.
Neg (absence) Gene_expression (absence) of RANKL in osteoclast associated with arthritis
17) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945067 Disease Relevance 0.59 Pain Relevance 0.24
No overall difference was noted in RANKL or OPG concentrations between the groups of patients with erosive and nonerosive PsA (Figure 1g and 1h).


Gene_expression (concentrations) of RANKL associated with arthritis
18) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945067 Disease Relevance 1.47 Pain Relevance 0.69
IL-17 also induces the expression of matrix metalloproteinase-1 and -13 in RA synovial cells and osteoblasts [15,16], and induces the expression of RANKL (receptor activator of nuclear factor-?
Gene_expression (expression) of RANKL in synovial cells associated with rheumatoid arthritis and metalloproteinase
19) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 1.48 Pain Relevance 0.62
The serum sRANKL levels and the ratio of sRANKL to OPG were significantly higher in patients with AS than those of controls.
Gene_expression (levels) of sRANKL
20) Confidence 0.01 Published 2006 Journal Rheumatology (Oxford) Section Body Doc Link 16567356 Disease Relevance 0.20 Pain Relevance 0

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