INT134657

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Context Info
Confidence 0.68
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 37
Total Number 37
Disease Relevance 11.58
Pain Relevance 4.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
muscle 4
tendon 3
muscle fibers 2
chondrocyte 1
plasma 1
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 252 100.00 Very High Very High Very High
Morphine 231 99.96 Very High Very High Very High
Inflammation 126 99.80 Very High Very High Very High
Kinase C 172 99.64 Very High Very High Very High
ischemia 41 99.28 Very High Very High Very High
Intracerebroventricular 9 99.24 Very High Very High Very High
Glutamate 31 95.28 Very High Very High Very High
cINOD 21 92.60 High High
agonist 11 92.12 High High
cytokine 71 87.20 High High
Disease Link Frequency Relevance Heat
Cancer 480 100.00 Very High Very High Very High
INFLAMMATION 162 99.80 Very High Very High Very High
Apoptosis 185 99.48 Very High Very High Very High
Cv Unclassified Under Development 105 99.28 Very High Very High Very High
Myelodysplastic Syndromes 62 99.04 Very High Very High Very High
Obesity 111 98.68 Very High Very High Very High
Chronic Myeloid Leukemia 8 98.28 Very High Very High Very High
Death 41 97.52 Very High Very High Very High
Osteoporosis 16 96.56 Very High Very High Very High
Stomach Cancer 22 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In muscle fibers at the MTJ areas, the colocalization of p-Akt1/PKB?
Localization (colocalization) of PKB in muscle fibers
1) Confidence 0.68 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2864450 Disease Relevance 0 Pain Relevance 0
In comparison to studies only in muscle, tendon, or in bone cells, we performed a quantitative immunohistochemical analysis in sections, which allows localization of the functional Akt1/PKB?
Localization (localization) of PKB in tendon
2) Confidence 0.68 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2864450 Disease Relevance 0.08 Pain Relevance 0
In comparison to studies only in muscle, tendon, or in bone cells, we performed a quantitative immunohistochemical analysis in sections, which allows localization of the functional Akt1/PKB?
Localization (localization) of Akt in tendon
3) Confidence 0.68 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2864450 Disease Relevance 0.08 Pain Relevance 0
In comparison to studies only in muscle, tendon, or in bone cells, we performed a quantitative immunohistochemical analysis in sections, which allows localization of the functional Akt1/PKB?
Localization (localization) of Akt1 in tendon
4) Confidence 0.68 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2864450 Disease Relevance 0.08 Pain Relevance 0
In muscle fibers at the MTJ areas, the colocalization of p-Akt1/PKB?
Localization (colocalization) of p-Akt1 in muscle fibers
5) Confidence 0.62 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2864450 Disease Relevance 0 Pain Relevance 0
In conclusion, our data show that PDE4 inhibition resolves neutrophilic inflammation by promoting caspase-dependent apoptosis of inflammatory cells by targeting a PKA/PI3K/Akt-dependent survival pathway.
Localization (targeting) of Akt associated with inflammation and apoptosis
6) Confidence 0.60 Published 2010 Journal J. Leukoc. Biol. Section Abstract Doc Link 20103769 Disease Relevance 0.74 Pain Relevance 0.21
The several lines of evidence reveal that Akt, which functions downstream of PI3K, is associated with the invasiveness and motility of tumor cells [18,30-32] and the secretion of MMP-2 [18,33,34].
Localization (secretion) of Akt associated with cancer
7) Confidence 0.60 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2838820 Disease Relevance 0.56 Pain Relevance 0.03
Sections were incubated with a mouse monoclonal anti PTEN (Cell Signaling, Danvers, MA) or with anti p-AKT rabbit monoclonal antibody (1?
Localization (antibody) of AKT
8) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.11
Phosphorylation of the other three sites appears not to be regulated (6, 9). 4E-BP1 is one of the main effectors of mammalian target of rapamycin (mTOR), serine/threonine-protein kinase in the phosphoinositide 3-kinase (PI3-kinase)/Akt (RAC serine/threonine-protein kinase, also named protein kinase B, PKB) signaling pathway that integrates signals from extracellular stimuli, amino acid availability, and oxygen and energy status of the cells (8). 4E-BPs contain a TOR signaling (TOS) motif that binds the mTOR complex 1 (mTORC1) (6). mTORC1 controls the activity of 4E-BP1.
Localization (target) of Akt
9) Confidence 0.57 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0 Pain Relevance 0
Importantly, Akt proteins recruited to MOR lacked phosphorylation on both the Thr308 and Ser473 residues.
Localization (recruited) of Akt associated with opioid receptor
10) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.07 Pain Relevance 0.82
, a major downstream target of PKB/Akt was then assessed.
Localization (target) of PKB/Akt
11) Confidence 0.52 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2910663 Disease Relevance 0 Pain Relevance 0
Ramos and colleagues have shown in the presence of MGd, levels of pAKT are initially increased and then decreased right before cell death (Ramos et al 2006).
Localization (levels) of pAKT associated with death
12) Confidence 0.48 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673824 Disease Relevance 0.74 Pain Relevance 0
Following an intracerebroventricular (icv) injection of 10 nmol morphine, Akt was recruited to the synaptosomal membrane and activated by Thr308 and Ser473 phosphorylation.
Localization (recruited) of Akt associated with intracerebroventricular and morphine
13) Confidence 0.48 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890584 Disease Relevance 0.15 Pain Relevance 0.86
These studies suggest that other Src family kinases are not compensating for deficiency of Lyn, Hck, and Fgr, and argue that therapy directed at Src kinases will be ineffective in PV patients.
Localization (directed) of kinases associated with myelodysplastic syndromes
14) Confidence 0.36 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.96 Pain Relevance 0
In protein degradation, the opposite pathway happens, but additionally, decreased Akt-P leads to increased caspase-3 activity, further promoting degradation.
Localization (decreased) of Akt-P
15) Confidence 0.27 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.70 Pain Relevance 0.13
Recently, we have demonstrated that the Rac GTPase is also activated and subsequently translocated from the cytosol to the membrane of THP-1 monocytes in a fA?
Localization (translocated) of Rac in monocytes
16) Confidence 0.26 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.08 Pain Relevance 0.03
Studies in both pig and rat hearts demonstrated that the dephosphorylation of Cx43 and electrical uncoupling during ischaemia were prevented by IP in a PKC-dependent manner and that IP increased the co-localization of several protein kinases with Cx43 during ischemia [262,263].
Localization (localization) of kinases in hearts associated with kinase c, ischemia and cv unclassified under development
17) Confidence 0.26 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.62 Pain Relevance 0.21
The protein isoprenylation of Rac is critical for Rac's subcellular localization, interactions with RhoGDI, anchoring to the plasma membrane and ultimately to the activation of inflammatory signaling pathways [114].
Localization (localization) of Rac in plasma associated with inflammation
18) Confidence 0.25 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.46 Pain Relevance 0.13
Two important targets of PI3K in muscle and fat cells that have been shown to have a role in insulin-stimulated GLUT-4 translocation are the AKT and the protein kinase C (PKC).
Localization (translocation) of AKT in fat cells associated with kinase c and obesity
19) Confidence 0.24 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.16 Pain Relevance 0.10
In comparison to studies only in muscle, tendon, or in bone cells, we performed a quantitative immunohistochemical analysis in sections, which allows localization of the functional Akt1/PKB?
Localization (localization) of PKB in muscle
20) Confidence 0.23 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2864450 Disease Relevance 0.08 Pain Relevance 0

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