INT134660

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Context Info
Confidence 0.32
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 6.33
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
fat cells 3
hearts 2
ear 2
muscle 1
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 44 99.64 Very High Very High Very High
ischemia 3 99.28 Very High Very High Very High
agonist 5 92.12 High High
Inflammation 64 81.64 Quite High
substance P 3 75.00 Quite High
Root ganglion neuron 1 75.00 Quite High
Neuropeptide 2 71.20 Quite High
fibrosis 7 69.44 Quite High
qutenza 2 68.24 Quite High
Action potential 3 65.88 Quite High
Disease Link Frequency Relevance Heat
Myelodysplastic Syndromes 124 99.84 Very High Very High Very High
Cv Unclassified Under Development 68 99.28 Very High Very High Very High
Obesity 98 99.04 Very High Very High Very High
Death 10 98.48 Very High Very High Very High
Alagille Syndrome 66 97.84 Very High Very High Very High
Cancer 126 97.48 Very High Very High Very High
Stomach Cancer 66 95.56 Very High Very High Very High
Hyperoxia 49 92.48 High High
Reperfusion Injury 30 92.28 High High
Reticulocytosis 10 90.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ramos and colleagues have shown in the presence of MGd, levels of pAKT are initially increased and then decreased right before cell death (Ramos et al 2006).
Positive_regulation (increased) of Localization (levels) of pAKT associated with death
1) Confidence 0.32 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673824 Disease Relevance 0.74 Pain Relevance 0
These studies suggest that other Src family kinases are not compensating for deficiency of Lyn, Hck, and Fgr, and argue that therapy directed at Src kinases will be ineffective in PV patients.
Positive_regulation (ineffective) of Localization (directed) of kinases associated with myelodysplastic syndromes
2) Confidence 0.24 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.96 Pain Relevance 0
These studies suggest that other Src family kinases are not compensating for deficiency of Lyn, Hck, and Fgr, and argue that therapy directed at Src kinases will be ineffective in PV patients.
Positive_regulation (at) of Localization (directed) of kinases associated with myelodysplastic syndromes
3) Confidence 0.24 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.96 Pain Relevance 0
Studies in both pig and rat hearts demonstrated that the dephosphorylation of Cx43 and electrical uncoupling during ischaemia were prevented by IP in a PKC-dependent manner and that IP increased the co-localization of several protein kinases with Cx43 during ischemia [262,263].
Positive_regulation (increased) of Localization (localization) of kinases in hearts associated with kinase c, ischemia and cv unclassified under development
4) Confidence 0.22 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.62 Pain Relevance 0.21
Two important targets of PI3K in muscle and fat cells that have been shown to have a role in insulin-stimulated GLUT-4 translocation are the AKT and the protein kinase C (PKC).
Positive_regulation (stimulated) of Localization (translocation) of AKT in fat cells associated with kinase c and obesity
5) Confidence 0.16 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.16 Pain Relevance 0.10
Importantly, the active form of Akt, phosphorylated on Ser473, increased significantly after TNF-?
Positive_regulation (active) of Localization (form) of Akt
6) Confidence 0.14 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.48 Pain Relevance 0
Importantly, the active form of Akt, phosphorylated on Ser473, increased significantly after TNF-?
Positive_regulation (increased) of Localization (form) of Akt
7) Confidence 0.14 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.54 Pain Relevance 0
Importantly, the active form of Akt, phosphorylated on Ser473, increased significantly after TNF-?
Positive_regulation (after) of Localization (form) of Akt
8) Confidence 0.14 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.55 Pain Relevance 0
GlcNAc-TA induces the translocation of protein kinases Calpha and theta fused with enhanced green fluorescent protein (PKCalpha-EGFP and PKCtheta-EGFP) to the plasma membrane in stable transfectants, and reduces intracellular calcium mobilization induced by agonists of G-protein coupled receptors in various cell lines without causing irritation of the mouse ear.
Positive_regulation (induces) of Localization (translocation) of protein kinases Calpha in ear associated with agonist
9) Confidence 0.06 Published 2006 Journal J. Antibiot. Section Abstract Doc Link 16568714 Disease Relevance 0.14 Pain Relevance 0.32
Two important targets of PI3K in muscle and fat cells that have been shown to have a role in insulin-stimulated GLUT-4 translocation are the AKT and the protein kinase C (PKC).
Positive_regulation (stimulated) of in muscle Localization (translocation) of AKT in fat cells associated with kinase c and obesity
10) Confidence 0.05 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.16 Pain Relevance 0.10
This was the case, however, for diluent-treated as well as for rolipram-treated pups, indicating that rolipram did not restore alveolar surface area and RAC to control values.
Neg (not) Positive_regulation (restore) of Localization (area) of RAC
11) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 1.01 Pain Relevance 0.21

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