INT134662

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 1.69
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SOX9) nucleolus (SOX9) nucleus (SOX9)
extracellular matrix organization (SOX9) protein complex assembly (SOX9) protein complex (SOX9)
Anatomy Link Frequency
chondrocyte 2
SOX9 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 34 93.04 High High
backache 8 69.36 Quite High
Osteoarthritis 144 60.72 Quite High
Inflammation 166 44.48 Quite Low
rheumatoid arthritis 81 5.00 Very Low Very Low Very Low
cytokine 66 5.00 Very Low Very Low Very Low
Facet joint 38 5.00 Very Low Very Low Very Low
imagery 27 5.00 Very Low Very Low Very Low
Pain 23 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 47 95.40 Very High Very High Very High
Hypertrophy 4 87.92 High High
Apoptosis 200 85.28 High High
Aging 13 79.12 Quite High
Intervertebral Disk Degeneration 111 77.36 Quite High
Low Back Pain 8 69.36 Quite High
Osteoarthritis 164 60.72 Quite High
INFLAMMATION 159 44.48 Quite Low
Osteoporosis 5 30.24 Quite Low
Death 6 23.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To demonstrate that the hypertonicity-induced chondrogenic marker expression was indeed mediated by NFAT5, we used RNAi to confirm that knockdown of NFAT5 significantly inhibited hypertonic induction of its own transcription as discussed before, significantly suppressed the tonicity-mediated induction of known NFAT5 targets, and, most importantly, significantly eliminated the hypertonicity-mediated mRNA expression of chondrogenic marker genes (COL2, AGC1, SOX9 and COL1).


Positive_regulation (mediated) of Gene_expression (expression) of SOX9
1) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.06 Pain Relevance 0.03
They used adenoviral delivery vectors expressing Sox9 to infect a chondroblastic cell line and human disc cells; Sox9 and Type II collagen production increased.
Positive_regulation (increased) of Gene_expression (production) of Sox9
2) Confidence 0.41 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.36 Pain Relevance 0
The in vivo transfection of the SOX9 gene by adenoviral vector using the rabbit stab model resulted in maintenance of a chondrocytic appearance over 5 weeks.70
Positive_regulation (over) of Gene_expression (transfection) of SOX9
3) Confidence 0.36 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.08 Pain Relevance 0.05
The in vivo transfection of the SOX9 gene by adenoviral vector using the rabbit stab model resulted in maintenance of a chondrocytic appearance over 5 weeks.70
Positive_regulation (transfection) of Gene_expression (transfection) of SOX9
4) Confidence 0.36 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.07 Pain Relevance 0.04
We have used transfection with adenoviral SOX-9, a transcription factor involved in differentiation of MSCs along the chondrogenic lineage, combined with culture in a specialised medium, to differentiate monolayer MSCs to NP-like (chondrocyte-like) cells, as shown by real-time quantitative polymerase chain reaction for NP-marker genes.
Positive_regulation (transfection) of Gene_expression (transfection) of adenoviral SOX-9 in chondrocyte
5) Confidence 0.17 Published 2006 Journal Biomaterials Section Abstract Doc Link 16569429 Disease Relevance 0.14 Pain Relevance 0.07
The aforementioned findings were consistent with the real-time PCR results, which showed the corresponding upregulation of SOX-9, aggrecan and type II collagen gene expression but downregulation of type I collagen expression by MPCs cultured in the presence of PPS.
Positive_regulation (upregulation) of Gene_expression (expression) of SOX-9
6) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.09 Pain Relevance 0
In 10-day MMC, a strong upregulation of SOX-9 gene expression was observed at 10 ?
Positive_regulation (upregulation) of Gene_expression (expression) of SOX-9
7) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0 Pain Relevance 0
They found that collagen synthesis could be enhanced by over-expression of BMP-13 and of the transcription factor Sox9 [131].
Positive_regulation (over) of Gene_expression (expression) of transcription factor Sox9
8) Confidence 0.07 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2899423 Disease Relevance 0 Pain Relevance 0
1-integrin and activation of Shc, ERK 1/2 and Sox-9.
Positive_regulation (activation) of Gene_expression (/) of Sox-9
9) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.31 Pain Relevance 0
Further, in these cultures the chondrogenic signalling cascade was activated with high expression of Shc, activated ERK 1/2 and Sox-9.
Positive_regulation (activated) of Gene_expression (expression) of Sox-9
10) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.05 Pain Relevance 0
1-integrin, Shc, activated ERK 1/2 and Sox-9.
Positive_regulation (activated) of Gene_expression (/) of Sox-9
11) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.13 Pain Relevance 0
Further, in these cultures the chondrogenic signalling cascade was activated with high expression of Shc, activated ERK 1/2 and Sox-9.
Positive_regulation (activated) of Gene_expression (expression) of Sox-9
12) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.05 Pain Relevance 0
1-integrin, Shc, activated ERK 1/2 and Sox-9 (Figure 3C).
Positive_regulation (activated) of Gene_expression (/) of Sox-9
13) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.36 Pain Relevance 0

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