INT134663

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 40
Total Number 44
Disease Relevance 9.07
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SOX9) nucleolus (SOX9) nucleus (SOX9)
extracellular matrix organization (SOX9) protein complex assembly (SOX9) protein complex (SOX9)
Anatomy Link Frequency
chondrocytes 4
Macrophages 3
nucleus pulposus 2
germ cells 2
cartilage 1
SOX9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 287 96.36 Very High Very High Very High
antagonist 25 93.28 High High
metalloproteinase 71 92.28 High High
chemokine 3 83.40 Quite High
headache 8 75.68 Quite High
cINOD 5 75.00 Quite High
Inflammation 242 72.72 Quite High
Arthritis 17 69.64 Quite High
backache 39 69.36 Quite High
cytokine 106 54.56 Quite High
Disease Link Frequency Relevance Heat
Arachnoid Cysts 204 100.00 Very High Very High Very High
Osteogenic Sarcomas 10 100.00 Very High Very High Very High
Peripheral Arterial Disease 102 99.84 Very High Very High Very High
Disease 256 98.40 Very High Very High Very High
Aging 27 97.48 Very High Very High Very High
Stress 51 96.92 Very High Very High Very High
Osteoarthritis 331 96.36 Very High Very High Very High
Chromosome Duplication 4 90.60 High High
Hypertrophy 7 87.92 High High
Malignant Neoplastic Disease 5 87.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Macrophages exposed to modified LDL express scavenger receptors (SRA, CD-36) that bind and promote the internalisation of oxidised LDL and a broad range of other particles and cell fragments (8,10).
Gene_expression (express) of SRA in Macrophages
1) Confidence 0.75 Published 2008 Journal International Journal of Clinical Practice Section Body Doc Link PMC2658007 Disease Relevance 0.45 Pain Relevance 0.13
Expression levels of AGC1, SOX9 and COL2 were studied as chondrogenic markers, while COL1 was studied as a dedifferentiation marker [34,35,49,50].
Gene_expression (Expression) of SOX9
2) Confidence 0.74 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.08 Pain Relevance 0
Macrophages exposed to modified LDL express scavenger receptors (SRA, CD-36) that bind and promote the internalisation of oxidised LDL and a broad range of other particles and cell fragments (8,10).
Gene_expression (express) of SRA in Macrophages
3) Confidence 0.65 Published 2008 Journal International Journal of Clinical Practice Section Body Doc Link PMC2658007 Disease Relevance 0.45 Pain Relevance 0.13
Macrophages exposed to modified LDL express scavenger receptors (SRA, CD-36) that bind and promote the internalisation of oxidised LDL and a broad range of other particles and cell fragments (8,10).
Gene_expression (modified) of SRA in Macrophages
4) Confidence 0.65 Published 2008 Journal International Journal of Clinical Practice Section Body Doc Link PMC2658007 Disease Relevance 0.46 Pain Relevance 0.13
Sox9 is expressed in mesenchymal condensations prior to and during chondrogenesis, and it has been shown to activate Col2a1, the gene encoding type II collagen, the major component of cartilage matrix 29, 30.
Gene_expression (expressed) of Sox9 in cartilage
5) Confidence 0.64 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.41 Pain Relevance 0
They used adenoviral delivery vectors expressing Sox9 to infect a chondroblastic cell line and human disc cells; Sox9 and Type II collagen production increased.
Gene_expression (production) of Sox9
6) Confidence 0.64 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.35 Pain Relevance 0
They used adenoviral delivery vectors expressing Sox9 to infect a chondroblastic cell line and human disc cells; Sox9 and Type II collagen production increased.
Gene_expression (expressing) of Sox9
7) Confidence 0.64 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.35 Pain Relevance 0
Expression and regulation of Sox9 gene also were seen at the nucleus pulposus cells 34.
Gene_expression (Expression) of Sox9 in nucleus pulposus
8) Confidence 0.64 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.29 Pain Relevance 0
In nucleus pulposus cells, SOX9-mediated aggrecan expression has recently been shown to critically depend on PI3K/AKT signaling [84].
Gene_expression (expression) of SOX9 in nucleus pulposus
9) Confidence 0.64 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.06 Pain Relevance 0
To demonstrate that the hypertonicity-induced chondrogenic marker expression was indeed mediated by NFAT5, we used RNAi to confirm that knockdown of NFAT5 significantly inhibited hypertonic induction of its own transcription as discussed before, significantly suppressed the tonicity-mediated induction of known NFAT5 targets, and, most importantly, significantly eliminated the hypertonicity-mediated mRNA expression of chondrogenic marker genes (COL2, AGC1, SOX9 and COL1).


Gene_expression (expression) of SOX9
10) Confidence 0.64 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.06 Pain Relevance 0.03
While other studies partially confirm that nonhuman chondrocytes respond to tonicity with altered aggrecan and SOX9 expression [4,8,10], we are reporting beneficial effects of isolating and expanding human normal and OA articular chondrocytes at physiological levels (380 mOsm).
Gene_expression (expression) of SOX9 in chondrocytes associated with osteoarthritis
11) Confidence 0.57 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.24 Pain Relevance 0.12
Expression levels of AGC1, SOX9 and COL2 were studied as chondrogenic markers, while COL1 was studied as a dedifferentiation marker [34,35,49,50].
Gene_expression (levels) of SOX9
12) Confidence 0.57 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.08 Pain Relevance 0
IL-1 treatment of cells derived from non-degenerate discs resulted in a decrease in both SOX6 and SOX9 gene expression.
Gene_expression (expression) of SOX9
13) Confidence 0.56 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0 Pain Relevance 0
No real effect was observed on SOX6 and SOX9 gene expression in cells derived from degenerate discs (Fig. 5a,b).
Gene_expression (expression) of SOX9
14) Confidence 0.56 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0 Pain Relevance 0
The in vivo transfection of the SOX9 gene by adenoviral vector using the rabbit stab model resulted in maintenance of a chondrocytic appearance over 5 weeks.70
Gene_expression (transfection) of SOX9
15) Confidence 0.55 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.07 Pain Relevance 0.04
The results demonstrated: (a) that expression levels of the catabolic genes MMP-3 and MMP-13 were suppressed and (b) mRNA expression levels of anabolic genes of collagen II, SOX9 and aggrecan were increased.
Gene_expression (expression) of SOX9
16) Confidence 0.55 Published 2009 Journal Phytochemistry Section Abstract Doc Link 19118849 Disease Relevance 0.28 Pain Relevance 0.34
For validation of the differentially expressed genes, we selected four of them for qRT-PCR: ATP10D, BEND5, SHROOM3 which were significantly altered in the ACs (p = 0.005, p = 0.008, p = 0.005, respectively), and SOX9 which showed the same trend, but did not reach significance (p = 0.08).
Gene_expression (selected) of SOX9
17) Confidence 0.53 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2841093 Disease Relevance 0.57 Pain Relevance 0
For all the studied genes except SOX9 (p = 0.09), the difference in expression profile between AC and arachnoid membranes was statistically significant (ATP10D: p = 0.005, BEND5: p = 0.007, SHROOM3: p = 0.005, figure 2).
Gene_expression (significant) of SOX9 associated with arachnoid cysts
18) Confidence 0.53 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2841093 Disease Relevance 0.48 Pain Relevance 0
Gruber et al considered that loss of expression of Sox9 in some of the anulus cell population may play a role in disc aging and degeneration, possibly by decreased modulation of the expression and production of Type II collagen of disc cells 36.
Gene_expression (expression) of Sox9 associated with aging
19) Confidence 0.50 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.37 Pain Relevance 0
The in vivo transfection of the SOX9 gene by adenoviral vector using the rabbit stab model resulted in maintenance of a chondrocytic appearance over 5 weeks.70
Gene_expression (transfection) of SOX9
20) Confidence 0.48 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.07 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox