INT13467

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Context Info
Confidence 0.68
First Reported 1991
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 36
Total Number 41
Disease Relevance 9.68
Pain Relevance 8.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCB1) ATPase activity (ABCB1) plasma membrane (ABCB1)
transmembrane transport (ABCB1)
Anatomy Link Frequency
plasma 4
CAR 2
pancreas 2
axial skeleton 1
livers 1
ABCB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 16 99.98 Very High Very High Very High
methadone 188 99.58 Very High Very High Very High
Transcranial magnetic stimulation 378 99.12 Very High Very High Very High
Paracetamol 31 99.12 Very High Very High Very High
cocaine 16 98.68 Very High Very High Very High
COX-2 inhibitor 52 97.92 Very High Very High Very High
antidepressant 4 97.84 Very High Very High Very High
fluoxetine 2 97.64 Very High Very High Very High
Endep 2 96.84 Very High Very High Very High
cINOD 22 96.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Biliary Liver Cirrhosis 16 99.92 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 41 99.64 Very High Very High Very High
Disease 99 99.48 Very High Very High Very High
Overdose 13 99.48 Very High Very High Very High
Uterine Cancer 1 99.26 Very High Very High Very High
Scoliosis 314 99.12 Very High Very High Very High
Breast Cancer 81 98.28 Very High Very High Very High
Peripheral Arterial Disease 11 96.68 Very High Very High Very High
Cancer 251 95.76 Very High Very High Very High
Apoptosis 205 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KHOSR2 cells treated with MDR1 siRNA loaded nanoparticles showed increased accumulation of the P-gp substrate calcein-AM by enhancing the uptake and/or decreasing the efflux of these compounds.
Positive_regulation (accumulation) of P-gp
1) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0.13 Pain Relevance 0.03
The findings also suggest that the P-glycoprotein induced by MMC differs from that induced by doxorubicin, which is highly sensitive to modulation by lysosomotropic amines such as quinine and quinidine.
Positive_regulation (induced) of P-glycoprotein
2) Confidence 0.67 Published 1991 Journal Cancer Chemother. Pharmacol. Section Abstract Doc Link 1671830 Disease Relevance 0.24 Pain Relevance 0.14
A high dose of oxymatrine (30 mg/kg) also significantly inhibited the dramatic increase in expression of morphine-induced P-glycoprotein (P-gp), an ATP-dependent efflux pump acting at the blood-brain barrier, by Western blot analysis.
Positive_regulation (induced) of P-glycoprotein in brain associated with morphine
3) Confidence 0.67 Published 2010 Journal Integr Cancer Ther Section Abstract Doc Link 20587445 Disease Relevance 0 Pain Relevance 1.20
In cells cultured for three days in the presence of Devil's Claw preparations or pure harpagoside, a dose-dependent P-gp upregulation was found.
Positive_regulation (upregulation) of P-gp in Claw
4) Confidence 0.61 Published 2009 Journal Phytomedicine Section Body Doc Link 19577448 Disease Relevance 0.12 Pain Relevance 0
Up-regulation of MRP5, MDR1, and BCRP mRNA occurred in PBC livers.
Positive_regulation (Up-regulation) of MDR1 in livers associated with biliary liver cirrhosis
5) Confidence 0.55 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 1.27 Pain Relevance 0.56
Increased P-gp protein was confirmed immunohistochemically and was found to localize to areas of PCNA-positive hepatocytes, which were detected in APAP overdose and PBC livers.
Positive_regulation (Increased) of P-gp protein in hepatocytes associated with biliary liver cirrhosis, paracetamol and overdose
6) Confidence 0.55 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 1.38 Pain Relevance 0.57
The stimulation of the MDR1-ATPase by these agents does not correlate with their known biochemical or pharmacological activities but rather with their hydrophobicity.
Positive_regulation (stimulation) of MDR1
7) Confidence 0.53 Published 1994 Journal FASEB J. Section Abstract Doc Link 7914178 Disease Relevance 0 Pain Relevance 0.10
Enhancement of intracellular doxorubicin accumulation with MDR1 siRNA loaded nanoparticle delivery
Positive_regulation (Enhancement) of MDR1 siRNA
8) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0.08 Pain Relevance 0
MDR1 siRNA was applied to a well of KHOSR2 and incubated for 48 h.
Positive_regulation (incubated) of MDR1 siRNA
9) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0 Pain Relevance 0
CONCLUSION: The present study demonstrated that the placental intervillous space acted as a site of fentanyl deposit, a fact that may be explained by two hypotheses: (1) the blood collected from the placental intervillous space is arterial and, according to some investigators, the arterial plasma concentrations of the drugs administered to patients undergoing epidural anesthesia are higher than the venous concentrations, and (2) a possible role of P-glycoprotein (P-gp).


Spec (possible) Positive_regulation (role) of P-gp in plasma
10) Confidence 0.49 Published 2009 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 19330322 Disease Relevance 0 Pain Relevance 0
Piperine, genistein and curcumin have been suggested to stimulate P-glycoprotein-mediated efflux without increasing P-glycoprotein expression.
Positive_regulation (stimulate) of P-glycoprotein
11) Confidence 0.49 Published 2010 Journal Biol. Pharm. Bull. Section Abstract Doc Link 20118549 Disease Relevance 0.06 Pain Relevance 0.43
We reasoned that polymorphic variation of P-gp may contribute to differing responses of patients to antidepressant drugs.
Positive_regulation (variation) of P-gp associated with antidepressant
12) Confidence 0.49 Published 2002 Journal Pharmacogenomics J. Section Abstract Doc Link 12082591 Disease Relevance 0.30 Pain Relevance 0.66
However, recent studies suggested that methadone may be a substrate of P-glycoprotein (P-gp).
Positive_regulation (substrate) of P-gp associated with methadone
13) Confidence 0.49 Published 2004 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 14712343 Disease Relevance 0.07 Pain Relevance 0.49
RESULTS: In rat pancreas, MDR-1 (P-gp) and MRP-1 but in human pancreas MDR-1 (P-gp), MRP-1 and MRP-2 were found to be expressed.
Positive_regulation (pancreas) of P-gp in pancreas
14) Confidence 0.49 Published 2004 Journal Pancreas Section Body Doc Link 14707729 Disease Relevance 0.08 Pain Relevance 0
CONCLUSION: The present study demonstrated that the placental intervillous space acted as a site of fentanyl deposit, a fact that may be explained by two hypotheses: (1) the blood collected from the placental intervillous space is arterial and, according to some investigators, the arterial plasma concentrations of the drugs administered to patients undergoing epidural anesthesia are higher than the venous concentrations, and (2) a possible role of P-glycoprotein (P-gp).


Spec (possible) Positive_regulation (role) of P-glycoprotein in plasma
15) Confidence 0.49 Published 2009 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 19330322 Disease Relevance 0 Pain Relevance 0
ABCB1, ABCG2 and transferrin receptor proteins were detected and functional activity of ABCB1, ABCG2 and the ABCC family was quantified in efflux experiments.
Positive_regulation (activity) of ABCB1
16) Confidence 0.48 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 19013850 Disease Relevance 0 Pain Relevance 0.12
The mechanism may be its induction of CYP2C19 and intestinal p-glycoprotein [33•].
Positive_regulation (induction) of p-glycoprotein
17) Confidence 0.45 Published 2010 Journal Curr HIV/AIDS Rep Section Body Doc Link PMC2892618 Disease Relevance 0.20 Pain Relevance 1.24
In addition, rifampicin can reduce the plasma concentrations of drugs that are not metabolised (e.g. digoxin) by inducing drug transporters such as P-glycoprotein.
Positive_regulation (inducing) of P-glycoprotein in plasma
18) Confidence 0.45 Published 2003 Journal Clin Pharmacokinet Section Abstract Doc Link 12882588 Disease Relevance 0.31 Pain Relevance 0.31
These findings suggest that the antagonistic effect of concomitant DOX + HAAP treatment occurs as a result of interactive stimulation of P-gp, generating decreased intracellular drug concentrations.
Positive_regulation (stimulation) of P-gp associated with paracetamol
19) Confidence 0.45 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17526808 Disease Relevance 0.31 Pain Relevance 0.89
P-glycoprotein, an efflux transporter, is increased both by HIV disease and chronic cocaine use [8].
Positive_regulation (increased) of P-glycoprotein associated with acquired immune deficiency syndrome or hiv infection, disease and cocaine
20) Confidence 0.45 Published 2010 Journal Curr HIV/AIDS Rep Section Body Doc Link PMC2892618 Disease Relevance 0.42 Pain Relevance 0.67

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