INT134673

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 2.72
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (SYNM) cytoplasm (SYNM)
Anatomy Link Frequency
medial 1
node 1
thalamus 1
midbrain 1
SYNM (Homo sapiens)
Pain Link Frequency Relevance Heat
Thalamus 49 100.00 Very High Very High Very High
midbrain 8 100.00 Very High Very High Very High
insula 10 98.04 Very High Very High Very High
Anterior cingulate 26 96.88 Very High Very High Very High
positron emission tomography 54 95.28 Very High Very High Very High
cocaine 34 94.24 High High
Neurotransmitter 12 88.28 High High
Dopamine 226 87.40 High High
anesthesia 29 73.84 Quite High
imagery 108 64.36 Quite High
Disease Link Frequency Relevance Heat
Hypertension 4 98.40 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

16 96.28 Very High Very High Very High
Metabolic Syndrome 16 95.72 Very High Very High Very High
Atherosclerosis 20 94.24 High High
Hepatocellular Cancer 4 93.28 High High
Disorder Of Lipid Metabolism 96 89.84 High High
Attention Deficit Hyperactivity Disorder 79 84.00 Quite High
Unconsciousness 123 83.60 Quite High
Cognitive Disorder 75 80.96 Quite High
Sleep Disorders 67 74.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduced synemin synthesis might result in the destruction of the cytoskeleton.
Gene_expression (synthesis) of synemin
1) Confidence 0.75 Published 2006 Journal Lasers Med Sci Section Abstract Doc Link 16570120 Disease Relevance 0.22 Pain Relevance 0
The biases between LDL-F and all other LDL-C estimations were different between MetSyn and nonMetSyn subjects except for LDL-L which did not differ between the two study groups (Table 3).
Gene_expression (subjects) of Syn
2) Confidence 0.65 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1550231 Disease Relevance 0 Pain Relevance 0
The NCEP ATP III criteria for the diagnosis of the MetSyn are as follows: waist circumference >102 cm in men and >88 cm in women, TG ?
Gene_expression (diagnosis) of Syn
3) Confidence 0.65 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1550231 Disease Relevance 0.75 Pain Relevance 0
The biases between LDL-F and all other LDL-C estimations were different between MetSyn and nonMetSyn subjects except for LDL-L which did not differ between the two study groups (Table 3).
Gene_expression (subjects) of Syn
4) Confidence 0.65 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1550231 Disease Relevance 0 Pain Relevance 0
It should be noted that no differences were detected between MetSyn and nonMetSyn subjects when LDL-C was calculated according to the formulas proposed by Planella and Wagner (LDL-P and LDL-W, respectively) and when LDL-C levels were provided by the Lipoprint System (LDL-L).
Neg (no) Gene_expression (detected) of Syn
5) Confidence 0.65 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1550231 Disease Relevance 0.27 Pain Relevance 0
Posterior cingulate cortex (PCC) and medial prefrontal cortex (mPFC) are suggested to be major hubs of the DMN and connections between them have been found to be weaker in children than in young adults (Fair et al., 2008; Supekar et al., 2010).
Gene_expression (hubs) of DMN in medial
6) Confidence 0.54 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2955419 Disease Relevance 0.08 Pain Relevance 0
Adult type DMN has not been detected in sleeping preterm and term infants (Fransson et al., 2007, 2009).
Neg (not) Gene_expression (detected) of DMN
7) Confidence 0.49 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2955419 Disease Relevance 0 Pain Relevance 0
The DMN appears to be largely task independent and normally displays reduced activity during specific goal directed behavior [10].
Neg (independent) Gene_expression (independent) of DMN
8) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996305 Disease Relevance 0.07 Pain Relevance 0.16
Since DMN regions are deactivated during the VA task, a positive correlation between DAT and BOLD signals in these regions reflects less deactivation with higher DAT availability (e.g. a negative correlation with deactivation).
Gene_expression (regions) of DMN
9) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0 Pain Relevance 0.17
Specifically we hypothesized that subjects with high DAT availability would show attenuated DMN deactivation during an attention task.
Gene_expression (deactivation) of DMN
10) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0.43 Pain Relevance 0.33
Increased VA load (VA-load), produced higher activation in the thalamus and midbrain and higher deactivation in the DMN, the cingulate cortex (BAs 24 and 32), and left insula (Fig. 4; Table 2).
Gene_expression (produced) of DMN in thalamus associated with insula, midbrain and thalamus
11) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0.08 Pain Relevance 0.30
Conversely, Cg25 was found to be strongly connected with regions of the DMN such as the OFC.
Gene_expression (regions) of DMN
12) Confidence 0.32 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.20 Pain Relevance 0.28
Activity in the mPFC node of the DMN has been closely associated with self-reflection (e.g. [22,24,27,32]) and recent evidence suggests that the mPFC exerts the principal causality within the network [33].
Gene_expression (node) of DMN in node
13) Confidence 0.32 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.32 Pain Relevance 0
This hypothesis is consistent with the considerable overlap between the shared connectivity pattern of PMC areas and the TNN (DMN).
Gene_expression (areas) of DMN
14) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948030 Disease Relevance 0 Pain Relevance 0.05
According to [47], the common characteristics of 'emergence' are [here focussing on fMRI-derived "emergents" of resting state networks (RSNs) including the default mode network (DMN)]:
Gene_expression (focussing) of DMN
15) Confidence 0.25 Published 2010 Journal Nonlinear Biomed Phys Section Body Doc Link PMC2880806 Disease Relevance 0.12 Pain Relevance 0.03
Increased VA load (VA-load), produced higher activation in the thalamus and midbrain and higher deactivation in the DMN, the cingulate cortex (BAs 24 and 32), and left insula (Fig. 4; Table 2).
Gene_expression (produced) of DMN in midbrain associated with insula, midbrain and thalamus
16) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0.08 Pain Relevance 0.30

General Comments

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