INT134689

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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.07
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (ALDOA) cytosol (ALDOA) small molecule metabolic process (ALDOA)
lyase activity (ALDOA) extracellular region (ALDOA) carbohydrate metabolic process (ALDOA)
Anatomy Link Frequency
muscle 2
ALDOA (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 1 65.32 Quite High
Glutamate 2 39.60 Quite Low
tolerance 3 31.68 Quite Low
alcohol 1 31.28 Quite Low
Bioavailability 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 2 65.32 Quite High
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low
Emergencies 2 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Succinylcholine activates the muscle-type nAChR followed by desensitization.
Positive_regulation (activates) of muscle-type in muscle
1) Confidence 0.26 Published 2006 Journal Anesthesiology Section Body Doc Link 16571968 Disease Relevance 0 Pain Relevance 0
RESULTS: Succinylcholine concentration-dependently activated the muscle-type nAChR with an EC50 value of 10.8 microm (95% confidence interval, 9.8-11.9 microm), and after the initial activation, succinylcholine desensitized the muscle-type nAChR.
Positive_regulation (activated) of muscle-type in muscle
2) Confidence 0.26 Published 2006 Journal Anesthesiology Section Body Doc Link 16571968 Disease Relevance 0 Pain Relevance 0
In light of these surprising results, it was of interest to see whether the bioactivation of pharmacologically relevant low concentrations of GTN could be improved by the ALDH2 activator Alda-1.
Positive_regulation (activator) of Alda-1
3) Confidence 0.07 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0.07 Pain Relevance 0.03

General Comments

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