INT134697

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.18
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prnp, Nup214) transport (Nup214) Golgi apparatus (Prnp)
endoplasmic reticulum (Prnp) nucleolus (Prnp) plasma membrane (Prnp)
Anatomy Link Frequency
neurons 1
Prnp (Mus musculus)
Nup214 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 2 75.88 Quite High
Disease Link Frequency Relevance Heat
Cerebellar Diseases 1 98.88 Very High Very High Very High
Targeted Disruption 8 97.84 Very High Very High Very High
Disease 1 92.60 High High
Creutzfeldt Jakob Disease 2 75.00 Quite High
Apoptosis 1 71.72 Quite High
Frailty 1 68.76 Quite High
Ataxia 1 67.84 Quite High
Syndrome 1 66.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis detected a preclinical decrease of the calcium/calmodulin-dependent phosphatase calcineurin (CaN) in granule neurons, suggesting that dysregulation of CaN activity induced by mutant PrP may be responsible for the cerebellar dysfunction in Tg(PG14) mice.
PrP Spec (CaN) Positive_regulation (induced) of CaN in neurons associated with targeted disruption and cerebellar diseases
1) Confidence 0.44 Published 2006 Journal Proteomics Section Abstract Doc Link 16572473 Disease Relevance 1.18 Pain Relevance 0.13

General Comments

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