INT134743

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 5.33
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TEAD1) DNA binding (TEAD1)
Anatomy Link Frequency
nucleus 1
TEAD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 31 100.00 Very High Very High Very High
Electroencephalography 6 98.72 Very High Very High Very High
opioid receptor 16 98.68 Very High Very High Very High
cva 43 86.36 High High
Opioid 1 75.00 Quite High
headache 5 66.08 Quite High
Pain 4 62.72 Quite High
Morphine 2 43.84 Quite Low
Catecholamine 1 39.88 Quite Low
Central nervous system 54 34.64 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 36 100.00 Very High Very High Very High
Hemorrhage 229 99.20 Very High Very High Very High
Sepsis 130 97.20 Very High Very High Very High
Coma 5 97.04 Very High Very High Very High
Death 43 95.88 Very High Very High Very High
Encephalopathy 36 95.68 Very High Very High Very High
Edema 10 90.56 High High
Syndrome 6 90.40 High High
Multiple Organ Failure 4 86.64 High High
Cv General 3 Under Development 31 86.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been postulated that the anticoagulant effect of DrotAA may play a less important role in increasing survival rate in severe sepsis patients at high risk for death.
Positive_regulation (effect) of DrotAA associated with death and sepsis
1) Confidence 0.36 Published 2007 Journal Crit Care Section Body Doc Link PMC2230610 Disease Relevance 1.31 Pain Relevance 0.16
Administration of DrotAA was associated with an increased risk for serious bleeding during the infusion period in both the overall PROWESS patients (P = 0.024) and the surgical cohort (P = 0.006); however, the surgical patients did not demonstrate excessive risk of bleeding compared with nonsurgical patients who received DrotAA.
Positive_regulation (received) of DrotAA associated with hemorrhage
2) Confidence 0.36 Published 2007 Journal Crit Care Section Body Doc Link PMC2230610 Disease Relevance 0.62 Pain Relevance 0
From the very first clinical study, safety analyses have been included in each controlled trial conducted in DrotAA, and continuous safety surveillance has formed part of all studies undertaken for the purposes of registering the drug for commercial use.
Positive_regulation (conducted) of DrotAA
3) Confidence 0.36 Published 2007 Journal Crit Care Section Body Doc Link PMC2230610 Disease Relevance 0.65 Pain Relevance 0.16
Administration of DrotAA was associated with an increased risk for serious bleeding during the infusion period in both the overall PROWESS patients (P = 0.024) and the surgical cohort (P = 0.006); however, the surgical patients did not demonstrate excessive risk of bleeding compared with nonsurgical patients who received DrotAA.
Positive_regulation (Administration) of DrotAA associated with hemorrhage
4) Confidence 0.36 Published 2007 Journal Crit Care Section Body Doc Link PMC2230610 Disease Relevance 0.60 Pain Relevance 0
Although AP-1 proteins become constitutively expressed, the level of Ref-1, which is required for the DNA binding activity of AP-1, is significantly reduced in the nucleus of MDMs [201,202].
Positive_regulation (required) of Ref-1 in nucleus
5) Confidence 0.07 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.22 Pain Relevance 0
These data support a potential role of SV1 and SV2 proteins as possible biological modulator of human mu-opioid receptor.
Spec (possible) Positive_regulation (role) of SV1 associated with opioid receptor
6) Confidence 0.04 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16580639 Disease Relevance 0.08 Pain Relevance 0.59
Immunohistochemistry analysis was performed in order to assess whether the activation of the inflammatory transcriptional factor, NF-?
Spec (whether) Positive_regulation (activation) of inflammatory transcriptional factor associated with inflammation
7) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745573 Disease Relevance 0.55 Pain Relevance 0.13
APACHE: Acute Physiology and Chronic Health Evaluation; APC: activated protein C; DrotAA: Drotrecogin alfa (activated); EEG: electroencephalography; GCS: Glasgow Coma Scale; ICU: intensive care unit; SAE: sepsis-associated encephalopathy; SEP: somatosensory evoked potentials; SOFA: Sequential Organ Failure Assessment.


Positive_regulation (activated) of DrotAA associated with encephalopathy, electroencephalography, sepsis and coma
8) Confidence 0.01 Published 2010 Journal Crit Care Section Body Doc Link PMC2887172 Disease Relevance 1.30 Pain Relevance 0.10

General Comments

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