INT134748

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Context Info
Confidence 0.46
First Reported 2002
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 2.89
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transporter activity (SV2A) endoplasmic reticulum (SV2A) cytoplasm (SV2A)
Anatomy Link Frequency
CAR 2
SV2A (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 16 98.68 Very High Very High Very High
Catecholamine 16 89.20 High High
ischemia 19 84.32 Quite High
agonist 8 82.44 Quite High
Inflammation 6 75.72 Quite High
Opioid 1 75.00 Quite High
potassium channel 5 44.20 Quite Low
Morphine 2 43.84 Quite Low
Kinase C 2 33.56 Quite Low
adenocard 1 11.44 Low Low
Disease Link Frequency Relevance Heat
Sepsis 66 99.90 Very High Very High Very High
Depression 4 97.64 Very High Very High Very High
Pressure Volume 2 Under Development 8 94.84 High High
Hypertension 8 93.36 High High
Critical Illness 26 92.72 High High
Endotoxemia 36 90.16 High High
Coronary Artery Disease 13 84.32 Quite High
Heart Rate Under Development 67 83.96 Quite High
Hypotension 37 83.40 Quite High
Hypoalbuminemia 2 80.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gene-specific transactivation activity of isoform CAR(SV3)
Positive_regulation (transactivation) of SV3 in CAR
1) Confidence 0.46 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.04
The difference in the type of binding site may explain the observed gene-specific transactivation activity of CAR(SV3).
Positive_regulation (transactivation) of SV3 in CAR
2) Confidence 0.43 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0
These data support a potential role of SV1 and SV2 proteins as possible biological modulator of human mu-opioid receptor.
Spec (possible) Positive_regulation (role) of SV2 associated with opioid receptor
3) Confidence 0.42 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16580639 Disease Relevance 0.08 Pain Relevance 0.59
Thus the patient benefitted from improved myocardial contractility, increased CO, CI and SvO2 and reduced CVP and PAOP, and these beneficial changes lasted for several days after levosimendan infusion stopped.
Positive_regulation (increased) of SvO2
4) Confidence 0.05 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2843680 Disease Relevance 0.48 Pain Relevance 0.04
Whether a pharmacological increase in CI and SvO2 improves the overall outcome in human septic shock treated with vasopressin analogues should be addressed in randomized controlled clinical trials.


Spec (Whether) Positive_regulation (increase) of SvO2 associated with sepsis
5) Confidence 0.00 Published 2006 Journal Crit Care Section Body Doc Link PMC1751059 Disease Relevance 0.40 Pain Relevance 0
In addition, endotoxin infusion contributed to increases in DO2I (p = 0.003) and SvO2 (p = 0.04) that were accompanied by a decrease in O2-ER (p = 0.026; all versus healthy state, T1; Figure 2).
Positive_regulation (increases) of SvO2
6) Confidence 0.00 Published 2006 Journal Crit Care Section Body Doc Link PMC1751059 Disease Relevance 0.32 Pain Relevance 0
In the present study, dobutamine caused dose-dependent increases in MAP, CI, HR, DO2I and SvO2, thereby improving both systemic hemodynamics and global oxygen transport.
Positive_regulation (increases) of SvO2
7) Confidence 0.00 Published 2006 Journal Crit Care Section Body Doc Link PMC1751059 Disease Relevance 0.35 Pain Relevance 0.12
In addition, AVP infusion led to a marked decrease in DO2I, which was accompanied by a sustained increase in O2-ER and a decrease in SvO2 (each p < 0.001 versus control; Figure 2).
Positive_regulation (increase) of SvO2
8) Confidence 0.00 Published 2006 Journal Crit Care Section Body Doc Link PMC1751059 Disease Relevance 0.19 Pain Relevance 0
For example, arterial-venous microcirculatory shunting in sepsis may increase SvO2, thus pretending adequate tissue oxygenation, while regional tissue dysoxia is present [47].


Spec (may) Positive_regulation (increase) of SvO2 associated with sepsis
9) Confidence 0.00 Published 2002 Journal Crit Care Section Body Doc Link PMC137397 Disease Relevance 0.39 Pain Relevance 0
SvO2 has been promoted as an indicator of changes in CO.
Positive_regulation (promoted) of SvO2
10) Confidence 0.00 Published 2002 Journal Crit Care Section Body Doc Link PMC137397 Disease Relevance 0.68 Pain Relevance 0.03

General Comments

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