INT134749

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2009
Negated 3
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 3.61
Pain Relevance 3.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TEAD1) DNA binding (TEAD1)
Anatomy Link Frequency
lung 2
brain 1
TEAD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 64 99.86 Very High Very High Very High
cva 36 92.56 High High
Morphine 8 79.52 Quite High
Opioid 4 75.00 Quite High
Central nervous system 56 74.24 Quite High
cytokine 24 40.80 Quite Low
Inflammation 12 5.00 Very Low Very Low Very Low
headache 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 4 99.60 Very High Very High Very High
Sepsis 92 99.02 Very High Very High Very High
Hemorrhage 228 98.28 Very High Very High Very High
Hepatotoxicity 4 94.76 High High
Cv General 3 Under Development 24 92.56 High High
Disease 22 91.28 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 282 87.36 High High
Ecchymosis 8 76.40 Quite High
Death 38 62.08 Quite High
Body Weight 4 42.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DrotAA is not recommended for use in persons under the age of 18 years and should not therefore be used in these patients.
Neg (not) Gene_expression (used) of DrotAA
1) Confidence 0.48 Published 2007 Journal Crit Care Section Body Doc Link PMC2230610 Disease Relevance 0.50 Pain Relevance 0.06
DrotAA is not indicated for patients with single organ dysfunction and in particular should not be used in patients with single organ dysfunction and recent surgery.


Neg (not) Gene_expression (used) of DrotAA
2) Confidence 0.48 Published 2007 Journal Crit Care Section Body Doc Link PMC2230610 Disease Relevance 0.43 Pain Relevance 0
Given that the rate of serious bleeding events was also higher in ENHANCE during the post-infusion period, where, due to the short half-life of the drug, patients were not exposed to DrotAA, this suggests a higher baseline risk for bleeding in ENHANCE compared with PROWESS, with higher degrees of both haematologic and hepatic dysfunction, both of which are associated with increased bleeding risk.
Neg (not) Gene_expression (exposed) of DrotAA associated with hepatotoxicity, hemorrhage and cva
3) Confidence 0.48 Published 2007 Journal Crit Care Section Body Doc Link PMC2230610 Disease Relevance 1.17 Pain Relevance 0.05
XPRESS (Xigris and Prophylactic Heparin Evaluation in Severe Sepsis) [14] was an open label study, all the patients received DrotAA and the study drug was prophylactic heparin or placebo.
Gene_expression (received) of DrotAA associated with sepsis
4) Confidence 0.48 Published 2007 Journal Crit Care Section Body Doc Link PMC2230610 Disease Relevance 0.87 Pain Relevance 0.10
Despite being expressed, AP-1 in MDMs of some tissues, such as the lung, lacks the ability to bind DNA because of the lack of expression of Ref-1, a protein that modulates the oxidation state of Fos [201,202].
Gene_expression (expression) of Ref-1 in lung
5) Confidence 0.09 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.22 Pain Relevance 0
Despite being expressed, AP-1 in MDMs of some tissues, such as the lung, lacks the ability to bind DNA because of the lack of expression of Ref-1, a protein that modulates the oxidation state of Fos [201,202].
Gene_expression (expression) of Ref-1 in lung
6) Confidence 0.08 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.07 Pain Relevance 0
In NMB cells expressing human MOR gene, transfection of SV1 or SV2 reduced binding activity of the endogenous MOR.
Gene_expression (transfection) of SV1 associated with opioid receptor
7) Confidence 0.06 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16580639 Disease Relevance 0.08 Pain Relevance 0.69
In a receptor binding assay, cells expressing the SV1 and SV2 do not exhibit binding to [(3)H]diprenorphine.
Gene_expression (expressing) of SV1
8) Confidence 0.06 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16580639 Disease Relevance 0.10 Pain Relevance 0.81
In vitro translation of SV1 and SV2 produced proteins with the predicted molecular weights.
Gene_expression (produced) of SV1
9) Confidence 0.05 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16580639 Disease Relevance 0.08 Pain Relevance 0.67
SV1 and SV2 of hMOR were present in human neuroblastoma NMB cells and human whole brain confirmed by RT-PCR.
Gene_expression (present) of SV1 in brain associated with neuroblastoma
10) Confidence 0.05 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16580639 Disease Relevance 0.10 Pain Relevance 0.78

General Comments

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