INT134756

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 11.14
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hif1a) signal transduction (Hif1a) nucleolus (Hif1a)
nucleus (Hif1a) protein binding transcription factor activity (Hif1a) DNA binding (Hif1a)
Anatomy Link Frequency
retina 2
brain 2
Hif1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 20 99.76 Very High Very High Very High
ischemia 96 99.08 Very High Very High Very High
adenocard 17 93.56 High High
potassium channel 10 91.04 High High
qutenza 3 86.76 High High
Inflammation 73 85.76 High High
Enkephalin 2 81.84 Quite High
Glutamate receptor 12 78.60 Quite High
antagonist 5 74.80 Quite High
calcitonin gene related peptide 3 73.28 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 537 100.00 Very High Very High Very High
Cv Unclassified Under Development 82 99.08 Very High Very High Very High
Ocular Hypertension 12 97.80 Very High Very High Very High
Apoptosis 50 97.56 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 6 96.20 Very High Very High Very High
Increased Venous Pressure Under Development 14 90.96 High High
INFLAMMATION 85 85.76 High High
Reperfusion Injury 22 84.32 Quite High
Retina Disease 8 83.56 Quite High
Stress 27 83.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, temporal [17] and spatial [16,17] correlations between increased levels of HIF-1?
Positive_regulation (increased) of Gene_expression (levels) of HIF-1
1) Confidence 0.50 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.19 Pain Relevance 0
, the regulatory subunit of HIF-1, and increased VEGF expression have been shown, indicating that HIF-1 may control the expression of VEGF in the retina under hypoxic conditions.
Positive_regulation (increased) of Gene_expression (expression) of HIF-1 in retina associated with hypoxia
2) Confidence 0.36 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.07 Pain Relevance 0
HPC markedly increased the expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and DOR, but intravitreal administration of HIF-1alpha-specific small interfering RNA abrogated the up-regulation of DOR.
Positive_regulation (increased) of Gene_expression (expression) of hypoxia-inducible factor-1alpha associated with hypoxia and opioid receptor
3) Confidence 0.34 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19054276 Disease Relevance 1.10 Pain Relevance 0.54
HPC markedly increased the expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and DOR, but intravitreal administration of HIF-1alpha-specific small interfering RNA abrogated the up-regulation of DOR.
Positive_regulation (increased) of Gene_expression (expression) of HIF-1alpha associated with hypoxia and opioid receptor
4) Confidence 0.34 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19054276 Disease Relevance 1.10 Pain Relevance 0.54
Similarly, Bernaudin et al. [43] found increased expression of 18 genes in the neonatal rat brain following hypoxia (8% O2 for 3 h) including several known hypoxia inducible genes such as MAP kinase phosphatase-1 (MKP-1), several HIF-1 target genes including VEGF and GLUT-1, genes implicated in apoptosis, signal transduction molecules, and transcription factors.
Positive_regulation (increased) of Gene_expression (expression) of HIF-1 in brain associated with hypoxia and apoptosis
5) Confidence 0.33 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.02 Pain Relevance 0.23
The protein level of HIF-1?
Positive_regulation (level) of Gene_expression (level) of HIF-1
6) Confidence 0.32 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.41 Pain Relevance 0.05
The ghrelin-enhanced acceleration of healing of ischemia/perfusion induced lesions was accompanied by enhanced expression of mRNA for HIF-1alpha and by diminution of the ischemia/reperfusion induced increase in mRNA expression for TNF-alpha.
Positive_regulation (enhanced) of Gene_expression (expression) of HIF-1alpha associated with ischemia
7) Confidence 0.31 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16581065 Disease Relevance 0.90 Pain Relevance 0.53
For example, hypoxic stimulus leads to increased stability and expression of hypoxia-induced factor 1 (HIF-1) in these cells.
Positive_regulation (increased) of Gene_expression (expression) of hypoxia-induced factor 1 associated with hypoxia
8) Confidence 0.09 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2806855 Disease Relevance 1.09 Pain Relevance 0.20
For example, hypoxic stimulus leads to increased stability and expression of hypoxia-induced factor 1 (HIF-1) in these cells.
Positive_regulation (leads) of Gene_expression (expression) of hypoxia-induced factor 1 associated with hypoxia
9) Confidence 0.09 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2806855 Disease Relevance 1.09 Pain Relevance 0.20
For example, hypoxic stimulus leads to increased stability and expression of hypoxia-induced factor 1 (HIF-1) in these cells.
Positive_regulation (leads) of Gene_expression (expression) of HIF-1 associated with hypoxia
10) Confidence 0.07 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2806855 Disease Relevance 1.09 Pain Relevance 0.20
For example, hypoxic stimulus leads to increased stability and expression of hypoxia-induced factor 1 (HIF-1) in these cells.
Positive_regulation (increased) of Gene_expression (expression) of HIF-1 associated with hypoxia
11) Confidence 0.07 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2806855 Disease Relevance 1.09 Pain Relevance 0.20

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