INT134761

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Context Info
Confidence 0.20
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.76
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl, Tnf) extracellular region (Ghrl, Tnf) signal transduction (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
sensory nerves 2
Ghrl (Rattus norvegicus)
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 1 100.00 Very High Very High Very High
qutenza 3 97.24 Very High Very High Very High
calcitonin gene related peptide 3 95.72 Very High Very High Very High
ischemia 12 94.42 High High
Inflammation 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 1 100.00 Very High Very High Very High
Necrosis 1 100.00 Very High Very High Very High
Cv Unclassified Under Development 12 94.42 High High
Hypoxia 1 92.48 High High
Increased Venous Pressure Under Development 2 75.00 Quite High
Reperfusion Injury 1 75.00 Quite High
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was (1) to investigate the effect of acylated ghrelin on the formation and healing of acute gastric mucosal lesions induced by ischemia-reperfusion and gastric mucosal blood flow in rats; (2) to analyse the effects of the deactivation of afferent sensory nerves with capsaicin and of the inhibition of nitric oxide (NO)-synthase by NG-nitro-l-arginine (l-NNA) on the ghrelin-induced protection; (3) to examine the influence of ghrelin on nuclear factor-kappa B (NF-kappaB) activation and on release of proinflammatory cytokines, such as tumor necrosis factor-alpha, (4) to assess the effect of ghrelin on the mRNA expression of constitutive nitric oxide synthase (cNOS), calcitonin gene related peptide (CGRP) and angiogenesis related proteins such as hypoxia inducible factor-1 alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF), and (5) to determine the effect of ischemia/reperfusion on the gastric mucosa expression of ghrelin in rats without and with administration of exogenous hormone.
ghrelin Regulation (influence) of Localization (release) of tumor necrosis factor-alpha in sensory nerves associated with calcitonin gene related peptide, necrosis, qutenza, hypoxia, cancer, ischemia and cytokine
1) Confidence 0.20 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16581065 Disease Relevance 0.76 Pain Relevance 0.40

General Comments

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