INT134776

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.84
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pln) protein complex (Pln)
Pln (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 2 81.40 Quite High
Pain 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 14 99.98 Very High Very High Very High
Coronary Heart Disease 10 99.24 Very High Very High Very High
Hypertrophy 30 89.00 High High
Targeted Disruption 28 82.44 Quite High
Pulmonary Disease 6 64.76 Quite High
Hypertension 2 62.00 Quite High
Stress 2 16.08 Low Low
Sprains And Strains 8 5.00 Very Low Very Low Very Low
Dislocations 4 5.00 Very Low Very Low Very Low
Frailty 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, chronic alveolar hypoxia induces hypophosphorylation of PLB at Ser16, which might be a mechanism for impaired relaxation and diastolic dysfunction in both the RV and LV.
Positive_regulation (induces) of Phosphorylation (hypophosphorylation) of PLB associated with hypoxia and coronary heart disease
1) Confidence 0.59 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16582020 Disease Relevance 0.91 Pain Relevance 0.07
Alveolar hypoxia induced a 38%, 47%, and 27% reduction in Ser16-phosphorylated phospholamban (PLB) in the RV after 1, 2, and 4 wk of hypoxia, respectively, and at the same time points, Ser16-phosphorylated PLB in the LV was downregulated by 32%, 34%, and 25% (all P < 0.05).
Positive_regulation (induced) of Phosphorylation (phosphorylated) of PLB associated with hypoxia
2) Confidence 0.40 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16582020 Disease Relevance 1.15 Pain Relevance 0.08
Specifically, the fact that S6K1 Thr389 phosphorylation is elevated in the PLN in parallel with increased PKB Thr308 phosphorylation suggests that the inhibitory effect of AMPK on mTORC1 is not the only mechanism at work.
Positive_regulation (elevated) of Phosphorylation (phosphorylation) of PLN
3) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.39 Pain Relevance 0
Specifically, the fact that S6K1 Thr389 phosphorylation is elevated in the PLN in parallel with increased PKB Thr308 phosphorylation suggests that the inhibitory effect of AMPK on mTORC1 is not the only mechanism at work.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of PLN
4) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.39 Pain Relevance 0

General Comments

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