INT134789

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Context Info
Confidence 0.30
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.22
Pain Relevance 0.78

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peptidase activity (Adam10) nucleocytoplasmic transport (Adam10) Golgi apparatus (Adam10)
nucleus (Adam10) cytoplasm (Adam10)
Adam10 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 8 99.04 Very High Very High Very High
qutenza 10 84.76 Quite High
Inflammation 2 63.44 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 4 98.88 Very High Very High Very High
Cancer 8 94.64 High High
Breast Cancer 6 75.00 Quite High
INFLAMMATION 2 63.44 Quite High
Metastasis 4 58.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically ADAM-10 produces the same growth-inhibitory products from Substance P (i.e., SP (1-7)) that Neprilysin does, so that loss of ADAM-10 expression actually results in loss of production of growth inhibitory peptides from Substance P.
Negative_regulation (loss) of Gene_expression (expression) of ADAM-10 associated with substance p
1) Confidence 0.30 Published 2006 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 16583263 Disease Relevance 0.49 Pain Relevance 0.36
At first glance, loss of ADAM-10 expression would be expected to result in decreased invasive capability, due to loss of matrix metalloprotease activity.
Negative_regulation (loss) of Gene_expression (expression) of ADAM-10
2) Confidence 0.22 Published 2006 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 16583263 Disease Relevance 0.73 Pain Relevance 0.41

General Comments

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