INT134795

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Context Info
Confidence 0.22
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 36.91
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Scrib) cell proliferation (Scrib) plasma membrane (Scrib)
cytoplasm (Scrib)
Anatomy Link Frequency
liver 5
granulocyte 1
lymph node 1
internal 1
bowel 1
Scrib (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 495 99.98 Very High Very High Very High
cINOD 27 99.38 Very High Very High Very High
Crohn's disease 42 99.16 Very High Very High Very High
agonist 85 97.80 Very High Very High Very High
alcohol 7 87.32 High High
palliative 11 73.84 Quite High
chemokine 7 68.00 Quite High
ketamine 4 65.16 Quite High
cryotherapy 3 63.08 Quite High
antagonist 4 61.88 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 1598 100.00 Very High Very High Very High
Metastasis 398 100.00 Very High Very High Very High
Colorectal Cancer 390 100.00 Very High Very High Very High
Cancer 1255 99.98 Very High Very High Very High
INFLAMMATION 495 99.98 Very High Very High Very High
Hepatocellular Cancer 7 99.92 Very High Very High Very High
Endometrial Cancer 14 99.80 Very High Very High Very High
Inflammatory Bowel Disease 133 99.30 Very High Very High Very High
Disease 217 99.16 Very High Very High Very High
Cholangiocarcinoma 2 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Key components of the RAS, namely angiotensinogen, ACE, ACE2, AT1R, AT2R, and the MasR were expressed in the sham liver, tumor-induced liver, and in CRC liver metastases (tumors) at all stages examined.
Positive_regulation (induced) of CRC in liver associated with cancer, colon cancer and metastasis
1) Confidence 0.22 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.98 Pain Relevance 0
We show a marked up-regulation of ACE during CRC metastases development, which would presumably favor CRC metastases growth by increasing production of ANG II.
Positive_regulation (regulation) of CRC associated with colon cancer and metastasis
2) Confidence 0.21 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.34 Pain Relevance 0
Dosing began on the day of CRC liver metastases induction and continued daily until the experimental endpoint.
Positive_regulation (induction) of CRC in liver associated with colon cancer and metastasis
3) Confidence 0.21 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.19 Pain Relevance 0
Nonsteroidal anti-inflammatory drugs such as indomethacin (IN) can exert anti-colorectal cancer (CRC) activity through cyclooxygenase independent mechanism, but the exactly biological mechanism is not completely known.
Positive_regulation (exert) of CRC associated with inflammation, colon cancer and cinod
4) Confidence 0.21 Published 2006 Journal J. Biochem. Mol. Biol. Section Abstract Doc Link 16584632 Disease Relevance 0.68 Pain Relevance 0.10
However, this modality is currently not accepted for CRC screening[10,11].
Neg (not) Positive_regulation (accepted) of CRC associated with colorectal cancer
5) Confidence 0.19 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2889851 Disease Relevance 1.32 Pain Relevance 0
Liver samples from 3-5 animals per time point and treatment were collected at 5, 10, 16 and 21 days after CRC liver metastases induction.
Positive_regulation (induction) of CRC in liver associated with colon cancer and metastasis
6) Confidence 0.18 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.34 Pain Relevance 0.03
In humans IGF-II was suggested to play a role in development of CRC, as substantiated by findings showing that IGF-II is overexpressed in about 44% of all colorectal tumors due to a loss of imprinting (LOI) in the IGF2 gene [13].
Positive_regulation (development) of CRC associated with colorectal cancer and colon cancer
7) Confidence 0.14 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.78 Pain Relevance 0
Mice were induced with CRC liver metastases and treated CGP42112A until termination of the experiment at day 21.
Positive_regulation (induced) of CRC in liver associated with colon cancer and metastasis
8) Confidence 0.09 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 1.21 Pain Relevance 0
For SNPs PTGS1 c.639C>A (p.Gly213Gly), IL8 c.-352T>A, and MTHFR c.1286A>C (p.Ala429Glu), minor alleles appeared associated with an increase in CRC, whereas for SNPs PLA2G2A c.435+230C>T, PPARG c.1431C>T (p.His477His), they were associated with a decrease in CRC risk.
Positive_regulation (increase) of CRC associated with colon cancer
9) Confidence 0.08 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.37 Pain Relevance 0
Indeed, in the same study population, we had previously observed an interaction between allelic combinations of CYP genes and consumption of red meat which leads to a strong increase in CRC risk [15].
Positive_regulation (increase) of CRC associated with colon cancer
10) Confidence 0.08 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.40 Pain Relevance 0.14
activation in CRC, hepatocellular carcinoma,
Positive_regulation (activation) of CRC associated with colorectal cancer and hepatocellular cancer
11) Confidence 0.07 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422873 Disease Relevance 1.46 Pain Relevance 0.23
By independent single-SNP analyses, three SNPs were shown to increase CRC risk: PTGS1 c.639C>A, IL8 c.-352T>A, and MTHFR c.1286A>C.
Positive_regulation (increase) of CRC associated with colon cancer
12) Confidence 0.07 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.86 Pain Relevance 0.03
is elevated in CRC [19], suggesting that this
Positive_regulation (elevated) of CRC associated with colorectal cancer
13) Confidence 0.07 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422873 Disease Relevance 1.91 Pain Relevance 0.10
CD and UC can be attributed to inflammation-induced CRC.
Positive_regulation (induced) of CRC associated with inflammatory bowel disease, inflammation, crohn's disease and colon cancer
14) Confidence 0.06 Published 2009 Journal PPAR Research Section Body Doc Link PMC2672162 Disease Relevance 1.83 Pain Relevance 0.30
As IL8 contributes to chronic inflammation, it would make sense that its overexpression would increase the risk for CRC, and therefore the allele c.-352A may rather enhance the transcriptional activity of the gene.
Positive_regulation (increase) of CRC associated with inflammation and colon cancer
15) Confidence 0.06 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.66 Pain Relevance 0.12
Independently, each low-penetrance allele contributes modestly to the increase in CRC risk, but its interactions with other susceptibility alleles and environmental factors can lead to a substantial increase in CRC risk, especially when exposed to certain dietary and lifestyle habits [4-6].
Positive_regulation (increase) of CRC associated with colon cancer
16) Confidence 0.05 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.72 Pain Relevance 0
Examination of internal consistency confirmed a trend in an increased CRC risk associated with the predisposing combination patterns, regardless of the mode of stratification used [Additional file 5].
Positive_regulation (increased) of CRC in internal associated with colon cancer
17) Confidence 0.05 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.29 Pain Relevance 0
Independently, each low-penetrance allele contributes modestly to the increase in CRC risk, but its interactions with other susceptibility alleles and environmental factors can lead to a substantial increase in CRC risk, especially when exposed to certain dietary and lifestyle habits [4-6].
Positive_regulation (increase) of CRC associated with colon cancer
18) Confidence 0.05 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.70 Pain Relevance 0
In addition, serum levels of M-CSF are more associated with lymph node metastasis than CEA and CA 19-9, which suggests that serum M-CSF elevation in CRC patients might help predict the risk of lymph node metastasis of this tumor.
Positive_regulation (elevation) of CRC in lymph node associated with colorectal cancer, cancer and metastasis
19) Confidence 0.05 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.44 Pain Relevance 0
The consequences of CRC can be significant as the
Positive_regulation (consequences) of CRC associated with colon cancer
20) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2672162 Disease Relevance 2.18 Pain Relevance 0.34

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