INT134798

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 27
Disease Relevance 13.94
Pain Relevance 2.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein binding, bridging (ANXA1) cilium (ANXA1) protein complex (ANXA1)
lipid metabolic process (ANXA1) cytoplasm (ANXA1) signal transduction (ANXA1)
Anatomy Link Frequency
lymph node 1
plasma 1
uterus 1
CCRF-CEM 1
epithelium 1
ANXA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 33 100.00 Very High Very High Very High
withdrawal 4 99.08 Very High Very High Very High
cINOD 81 99.00 Very High Very High Very High
diclofenac 106 98.88 Very High Very High Very High
Inflammation 502 98.52 Very High Very High Very High
Acute pain 1 97.32 Very High Very High Very High
Pain 7 94.60 High High
cytokine 34 90.32 High High
Central nervous system 4 82.36 Quite High
Chronic pancreatitis 4 82.20 Quite High
Disease Link Frequency Relevance Heat
Bladder Cancer 14 100.00 Very High Very High Very High
Overweight 22 99.44 Very High Very High Very High
Injury 4 98.96 Very High Very High Very High
Reprotox - General 1 33 98.80 Very High Very High Very High
Breast Cancer 188 98.62 Very High Very High Very High
INFLAMMATION 578 98.52 Very High Very High Very High
Uterine Fibroids 288 98.44 Very High Very High Very High
Cancer 466 97.88 Very High Very High Very High
Leukemia 16 97.88 Very High Very High Very High
Prostate Cancer 45 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of annexin 1 has been reported to decrease in androgen stimulated prostate cancer compared with benign prostatic epithelium [42].
Gene_expression (expression) of annexin 1 in epithelium associated with prostate cancer
1) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 1.14 Pain Relevance 0.08
Studies have already confirmed that annexin I is under-expressed in a majority of early stage prostate cancer.
Gene_expression (expressed) of annexin I associated with reprotox - general 1
2) Confidence 0.75 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 1.05 Pain Relevance 0.16
AnxA1 and Ac2-26 synthesis
Gene_expression (synthesis) of AnxA1
3) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.08 Pain Relevance 0.04
Functional analysis of ALX, AnxA1 and Ac2-26 differentially expressed genes
Gene_expression (expressed) of AnxA1
4) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.39 Pain Relevance 0.13
AnxA1 was expressed as a fusion protein with major basic protein linked to the N-terminal and subsequently cleaved with TEV protease.
Gene_expression (expressed) of AnxA1
5) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.08 Pain Relevance 0.04
Through matrix-assisted laser desorption ionization time of flight mass spectrometry and then NCBInr and SWISS-PROT databases searching, 12 protein spots were finally identified including galectin-1, annexin A1, annexin IV, transcription factor BTF3A, calreticulin.
Gene_expression (identified) of annexin A1
6) Confidence 0.65 Published 2006 Journal J. Biochem. Mol. Biol. Section Abstract Doc Link 16584632 Disease Relevance 0.84 Pain Relevance 0.06
They also found altered expression of a group of proteins in bladder cancer that have not been documented previously, including annexin I, 15-hydroxyprostaglandin dehydrogenase, galectin-1, lysophospholipase, and mitochondrial short-chain enoyl-coenzyme A hydratase 1 precursor [9].


Gene_expression (expression) of annexin I in bladder associated with bladder cancer
7) Confidence 0.65 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1852117 Disease Relevance 1.13 Pain Relevance 0
Surprisingly, only 19 probes were differentially expressed between AnxA1- and Ac2-26-treated cells.
Gene_expression (expressed) of AnxA1
8) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.55 Pain Relevance 0.18
There was also no detectable release of AnxA1 protein from either transfected cell line (as measured by ELISA, data not shown), suggesting that there was no interference by endogenous AnxA1 protein in the transfected HEK293 cells in the subsequent microarray experiments.


Neg (no) Gene_expression (detectable) of AnxA1 protein
9) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.31 Pain Relevance 0.03
Quantitative PCR experiments confirmed that the altered gene expression of these genes by AnxA1 was genuine (Figure 5A).
Gene_expression (expression) of AnxA1
10) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.23 Pain Relevance 0.04
We report a similar signature, partly expected, between AnxA1 and glucocorticoids and the novel association between AnxA1 and HDACIs; the latter, again, could act as a springboard for a comprehensive assessment of the novel biological properties of all these compounds


Gene_expression (expected) of AnxA1
11) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.06 Pain Relevance 0.03
The functional analysis of differentially expressed genes (3120, 103 and 118 probes for ALX, Ac226 and AnxA1 groups respectively) was made using Panther Classification System v6.1 (Applied Biosystems).
Gene_expression (groups) of AnxA1
12) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0 Pain Relevance 0
While no change in PBMC COX-2 expression was detected, annexin A1 (ANXA1) expression was induced in response to diclofenac, increasing 64 ± 41% (mean ± stdev) in this cell type.
Gene_expression (expression) of ANXA1 associated with diclofenac
13) Confidence 0.60 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2837611 Disease Relevance 0.73 Pain Relevance 0.48
Tissue injury resulted in a significant upregulation in the gene expression of interleukin-6 (IL-6; 63.3-fold), IL-8 (8.1-fold), chemokine (C-C motif) ligand 2 (CCL2; 8.9-fold), chemokine (C-X-C motif) ligand 1 (CXCL1; 30.5-fold), chemokine (C-X-C motif) ligand 2 (CXCL2; 26-fold) and annexin A1 (ANXA1; 12-fold).
Gene_expression (expression) of annexin A1 associated with chemokine and injury
14) Confidence 0.58 Published 2009 Journal Pain Section Abstract Doc Link 19233564 Disease Relevance 1.17 Pain Relevance 0.92
Therefore, we queried the Connectivity Map using the AnxA1 and Ac2-26 expression signatures obtained in our microarray analysis.
Gene_expression (expression) of AnxA1
15) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.13 Pain Relevance 0.05
We used two replicates for each group: CMV (control group, HEK293 cells), ALX (HEK293 transfected with ALX receptor), Ac226 (HEK293 cells transfected with ALX receptor and treated with 10 µM Ac2-26 peptide) and AnxA1 (HEK293 cells transfected with ALX receptor and treated with 0.5 µM AnxA1 peptide).
Gene_expression (transfected) of AnxA1 associated with cytomegalovirus infection
16) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.10 Pain Relevance 0
The Connectivity Map analysis also demonstrated similar profiles of gene expression for AnxA1 and two widely used glucocorticoids, beclomethasone and triamcinolone.
Gene_expression (expression) of AnxA1
17) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.99 Pain Relevance 0.23
Thus, we compared the expression levels of SGPP2 in peripheral lymph node and thymus tissues from AnxA1null and wild type (WT) animals by real time-PCR.
Gene_expression (expression) of AnxA1null in thymus
18) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0.05 Pain Relevance 0
We report an array of new potential markers of inflammatory responsiveness to NSAID therapy in overweight subjects that include PBMC expression of ANXA1 and caspase 8, as well as plasma concentrations of 5,6-DHET.
Gene_expression (expression) of ANXA1 in plasma associated with inflammation, cinod and overweight
19) Confidence 0.47 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2837611 Disease Relevance 0.86 Pain Relevance 0.45
Castro-Caldas et al [33] demonstrated that estrogen induced de novo expression of annexin A1 (ANXA1) and stimulated its secretion in the human CCRF-CEM acute lymphoblastic leukemia cell line apparently via a mechanism independent of the intracellular estrogen receptor.
Gene_expression (expression) of ANXA1 in CCRF-CEM associated with leukemia
20) Confidence 0.38 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.10 Pain Relevance 0

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