INT134818

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.11
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oxtr) signal transducer activity (Oxtr)
Anatomy Link Frequency
uterine 2
smooth muscles 1
Oxtr (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 31 100.00 Very High Very High Very High
agonist 6 97.84 Very High Very High Very High
Dismenorea 9 70.00 Quite High
Potency 4 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
anticonvulsant 3 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pre-term Labor 81 99.60 Very High Very High Very High
Hypoxia 6 96.32 Very High Very High Very High
Dysmenorrhea 9 70.00 Quite High
Premature Birth 19 66.96 Quite High
Embryonal Carcinoma 23 60.84 Quite High
Pre-eclampsia 138 51.60 Quite High
Acidosis 3 41.92 Quite Low
Targeted Disruption 8 37.68 Quite Low
Hypertension 81 13.16 Low Low
Benign Prostatic Hypertrophy 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate the relationship between the oxytocin (OT) receptor (OTR) quantity and the contractile features systematically, we measured the mRNA expression levels of OTR and L-type Ca(2+) channel alpha(1C)-subunit (alpha(1C)) and examined the regulatory mechanisms of OT-induced phasic or tonic contractions of the longitudinal smooth muscles in mouse uteri.
Regulation (levels) of OTR in smooth muscles
1) Confidence 0.45 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17148756 Disease Relevance 0 Pain Relevance 0
Other parturition-specific parameters such as the regulation of oxytocin receptor, prostaglandin F receptor or progesterone remained unchanged.
Regulation (regulation) of oxytocin receptor
2) Confidence 0.31 Published 2006 Journal J. Cell. Sci. Section Abstract Doc Link 16595547 Disease Relevance 0.14 Pain Relevance 0.07
To ascertain OTR involvement in OT-GKR-mediated cardiomyogenesis, OT-GKR-treated EBs were additionally exposed to 10?
Regulation (involvement) of OTR
3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.22 Pain Relevance 0.13
Indeed, OT receptor antagonists are effective in inducing uterine quiescence in various animals including humans at term [40].
Regulation (effective) of OT receptor in uterine associated with antagonist
4) Confidence 0.15 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.38 Pain Relevance 0.19
OTR antagonists have been reported to be effective in the treatment of preterm labor compared with beta agonists [78].
Regulation (effective) of OTR associated with antagonist, agonist and pre-term labor
5) Confidence 0.13 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.22 Pain Relevance 0.15
OTR antagonists are effective in inducing uterine quiescence in various animal species including humans at term.
Regulation (effective) of OTR in uterine associated with antagonist
6) Confidence 0.13 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.15 Pain Relevance 0.14

General Comments

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