INT134819

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 9
Disease Relevance 1.68
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gja3) plasma membrane (Gja3)
Anatomy Link Frequency
heart 6
skin 2
Gja3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dismenorea 1 99.36 Very High Very High Very High
Action potential 70 93.08 High High
action potential duration 140 82.00 Quite High
ischemia 7 67.40 Quite High
Acupuncture 4 50.00 Quite Low
analgesia 3 50.00 Quite Low
potassium channel 14 12.96 Low Low
Pain 1 10.00 Low Low
sodium channel 14 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dysmenorrhea 1 99.36 Very High Very High Very High
Premature Birth 1 96.32 Very High Very High Very High
Cv Unclassified Under Development 14 94.20 High High
Sprains And Strains 7 89.04 High High
Malignant Neoplastic Disease 7 87.40 High High
Targeted Disruption 37 84.88 Quite High
Heart Disease 21 72.52 Quite High
Dilated Cardiomyopathy 7 69.96 Quite High
Infarction 7 67.88 Quite High
Heart Rate Under Development 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the clinical setting, dyssynchronous activation of diseased myocardium with reduced Cx43 expression may lead to electrophysiological changes, which underlie the worsened prognosis often associated with pacing in the failing heart.
Positive_regulation (activation) of Gene_expression (expression) of Cx43 in heart
1) Confidence 0.50 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.06 Pain Relevance 0.18
RESULTS: Immunohistochemistry showed abundant Cx43 expression in some cells in the skin and subcutaneous tissue of rat ST36 acupoints.
Positive_regulation (abundant) of Gene_expression (expression) of Cx43 in skin
2) Confidence 0.49 Published 2009 Journal Chin. Med. J. Section Body Doc Link 19187618 Disease Relevance 0 Pain Relevance 0
Expression of connexin43 (Cx43), the major myometrial gap junction protein, is increased during delivery.
Positive_regulation (increased) of Gene_expression (Expression) of Cx43
3) Confidence 0.48 Published 2006 Journal J. Cell. Sci. Section Abstract Doc Link 16595547 Disease Relevance 0.20 Pain Relevance 0.10
We recently demonstrated that alterations in Cx43 expression in the wild-type mouse heart could be induced by ventricular pacing over a short period of time.
Positive_regulation (induced) of Gene_expression (expression) of Cx43 in heart
4) Confidence 0.46 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.66 Pain Relevance 0.03
In the present study, we hypothesized that alterations in Cx43 expression induced by pacing might have more profound effects on ventricular function and electrophysiology in the setting of reduced basal levels of Cx43.
Positive_regulation (induced) of Gene_expression (expression) of Cx43
5) Confidence 0.46 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.59 Pain Relevance 0.03
Similarly, we found that Iss was significantly increased in unpaced Cx43+/?
Positive_regulation (increased) of Gene_expression (/) of Cx43
6) Confidence 0.44 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.06
, or paced Cx43+/?
Positive_regulation (paced) of Gene_expression (/) of Cx43
7) Confidence 0.44 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.07
hearts, pacing resulted in a significant prolongation of ventricular effective refractory period and APD and significant diminution of Iss compared with unpaced Cx43+/?
Positive_regulation (resulted) of Gene_expression (/) of Cx43 in hearts
8) Confidence 0.44 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Abstract Doc Link PMC2614590 Disease Relevance 0.08 Pain Relevance 0.05
We investigated the effect of reduced Cx43 expression on pacing-induced remodeling of repolarizing currents using Cx43+/?
Positive_regulation (induced) of Gene_expression (using) of Cx43
9) Confidence 0.44 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.09 Pain Relevance 0.12

General Comments

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