INT134820

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Context Info
Confidence 0.64
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.84
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Gja1) Golgi apparatus (Gja1) transmembrane transport (Gja1)
cell-cell signaling (Gja1) cytoplasm (Gja1) signal transducer activity (Gja1)
Anatomy Link Frequency
visceral 2
ependymal cells 2
Gja1 (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 1 99.68 Very High Very High Very High
Dismenorea 1 99.36 Very High Very High Very High
Acupuncture 2 98.88 Very High Very High Very High
Visceral pain 1 98.28 Very High Very High Very High
analgesia 1 93.36 High High
Hippocampus 2 11.12 Low Low
Spinal cord 9 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Peripheral nervous system 8 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 9 100.00 Very High Very High Very High
Dysmenorrhea 1 99.36 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 98.28 Very High Very High Very High
Premature Birth 1 96.32 Very High Very High Very High
Autism 8 78.92 Quite High
Cerebral Edema 8 67.12 Quite High
Infection 2 60.32 Quite High
Disease 2 55.80 Quite High
Epilepsy 5 5.72 Low Low
Cancer 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of connexin43 (Cx43), the major myometrial gap junction protein, is increased during delivery.
Positive_regulation (increased) of Gene_expression (Expression) of connexin43
1) Confidence 0.64 Published 2006 Journal J. Cell. Sci. Section Abstract Doc Link 16595547 Disease Relevance 0.20 Pain Relevance 0.10
[Influence of connexin 43 gene knockout on the analgesic effect of acupuncture in visceral pain mice].
Positive_regulation ([Influence) of Gene_expression (knockout) of connexin 43 in visceral associated with targeted disruption, visceral pain, analgesic and acupuncture
2) Confidence 0.49 Published 2008 Journal Zhen Ci Yan Jiu Section Title Doc Link 18386636 Disease Relevance 0.10 Pain Relevance 0.39
Immunohistochemistry and electromicroscopy demonstrated that AQP4 deletion resulted in decreased expression of gap junction protein connexin43 (Cx43) [41], that is the main gap-junction protein in astrocytes as well as ependymal cells [77].
Positive_regulation (resulted) of Gene_expression (expression) of junction protein connexin43 in ependymal cells
3) Confidence 0.02 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.45 Pain Relevance 0

General Comments

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