INT134821

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Context Info
Confidence 0.77
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 52
Disease Relevance 7.45
Pain Relevance 4.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gja3) plasma membrane (Gja3)
Anatomy Link Frequency
heart 11
myocytes 3
myocardium 1
CAR 1
skin 1
Gja3 (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 15 99.64 Very High Very High Very High
Action potential 450 99.48 Very High Very High Very High
Acupuncture 20 99.44 Very High Very High Very High
action potential duration 900 99.42 Very High Very High Very High
Dismenorea 1 99.36 Very High Very High Very High
ischemia 45 96.36 Very High Very High Very High
Calcium channel 45 91.32 High High
potassium channel 90 90.56 High High
sodium channel 90 88.96 High High
Pain 5 25.00 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 306 100.00 Very High Very High Very High
Heart Disease 138 99.84 Very High Very High Very High
Dysmenorrhea 1 99.36 Very High Very High Very High
Cv Unclassified Under Development 90 99.00 Very High Very High Very High
Dilated Cardiomyopathy 45 98.92 Very High Very High Very High
Malignant Neoplastic Disease 45 98.24 Very High Very High Very High
Infarction 45 96.84 Very High Very High Very High
Premature Birth 1 96.32 Very High Very High Very High
Sprains And Strains 45 89.04 High High
Heart Rate Under Development 50 87.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the effect of reduced Cx43 expression on pacing-induced remodeling of repolarizing currents using Cx43+/?
Gene_expression (expression) of Cx43
1) Confidence 0.77 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.08 Pain Relevance 0.15
Significant elevations in the 4-AP-insensitive current, Iss, have been described in right ventricular myocytes from mice with conditional loss of Cx43 expression in the heart (9).
Gene_expression (expression) of Cx43 in heart
2) Confidence 0.77 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.06
Taken together, these data suggest that short-term pacing in the setting of reduced Cx43 expression, but not wild-type levels of Cx43, results in the prolongation of refractoriness without significantly affecting overall ventricular function.


Gene_expression (expression) of Cx43
3) Confidence 0.77 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.11
Thus, although short-term pacing in the wild-type murine heart is not associated with measurable electrophysiological effects, pacing in the setting of reduced baseline Cx43 expression results in significant prolongation of refractoriness and altered repolarization.
Gene_expression (expression) of Cx43 in heart
4) Confidence 0.77 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.15 Pain Relevance 0.14
In another model of loss of Cx43 expression, the heart-specific conditional knockout of Cx43, we observed a reduction in APD with correspondingly increased outward potassium currents (9).
Gene_expression (expression) of Cx43 in heart associated with targeted disruption and action potential duration
5) Confidence 0.77 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.20 Pain Relevance 0.12
Experimental models have demonstrated the relationship between decreased cardiac Cx43 expression and increased susceptibility to ventricular arrhythmias.
Gene_expression (expression) of Cx43
6) Confidence 0.77 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.63 Pain Relevance 0.04
In a heart-specific knockout of Cx43, we observed that ventricular expression levels of Cx43 are inversely related to inducibility into malignant ventricular arrhythmias (8).
Gene_expression (expression) of Cx43 in heart associated with targeted disruption and malignant neoplastic disease
7) Confidence 0.77 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.68 Pain Relevance 0.04
In the clinical setting, dyssynchronous activation of diseased myocardium with reduced Cx43 expression may lead to electrophysiological changes, which underlie the worsened prognosis often associated with pacing in the failing heart.
Gene_expression (expression) of Cx43 in heart
8) Confidence 0.77 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.06 Pain Relevance 0.17
Our data suggest that decreased expression of Cx43, which has been described in heart disease (20, 21, 24, 30), can influence the expression and/or function of active ion channels and, in combination with pacing, may lead to increased dispersion of repolarization properties.
Gene_expression (expression) of Cx43 in heart associated with heart disease
9) Confidence 0.77 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.25 Pain Relevance 0.04
A potential link between Cx43 expression and the remodeling of active ion channels has been suggested by experiments involving the infarct border zone in the canine model.
Gene_expression (expression) of Cx43
10) Confidence 0.77 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.19 Pain Relevance 0.03
To investigate how pacing in the setting of reduced Cx43 expression influences electrophysiological properties, we used whole-cell patch-clamp techniques to record action potentials in ventricular myocytes obtained from unpaced and paced wild-type and Cx43+/?
Gene_expression (expression) of Cx43 in myocytes associated with action potential
11) Confidence 0.77 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0 Pain Relevance 0.23
Altered expression of Cx43 in cardiac disease is a potentially significant contributor to arrhythmogenicity (19, 33).
Gene_expression (expression) of Cx43 associated with heart disease
12) Confidence 0.77 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.64 Pain Relevance 0.05
Thus, in combination with the data presented in this study, it is reasonable to conclude that reduced Cx43 expression, as observed in the infarct border zone and in paced Cx43+/?
Gene_expression (expression) of Cx43
13) Confidence 0.77 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.17 Pain Relevance 0
We recently demonstrated that alterations in Cx43 expression in the wild-type mouse heart could be induced by ventricular pacing over a short period of time.
Gene_expression (expression) of Cx43 in heart
14) Confidence 0.77 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.66 Pain Relevance 0.03
We have recently shown that short-term pacing in the mouse is associated with changes in connexin43 (Cx43) expression and localization but not with increased inducibility into sustained arrhythmias.
Gene_expression (expression) of Cx43
15) Confidence 0.77 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Abstract Doc Link PMC2614590 Disease Relevance 0.07 Pain Relevance 0
To study whether gap junctional intercellular communication participates in the transfer of acupoint signals and acupuncture analgesia, the expression of Cx43 was studied in Zusanli (ST36) acupoints compared with control non-acupoint regions in rats after acupuncture.
Gene_expression (expression) of Cx43 associated with acupuncture and analgesia
16) Confidence 0.76 Published 2009 Journal Chin. Med. J. Section Abstract Doc Link 19187618 Disease Relevance 0.09 Pain Relevance 0.43
RESULTS: Immunohistochemistry showed abundant Cx43 expression in some cells in the skin and subcutaneous tissue of rat ST36 acupoints.
Gene_expression (expression) of Cx43 in skin
17) Confidence 0.76 Published 2009 Journal Chin. Med. J. Section Body Doc Link 19187618 Disease Relevance 0 Pain Relevance 0
METHODS: The expression of Cx43 was detected by immunohistochemistry, immunoblotting, and RT-PCR for the Cx43 protein and mRNA.
Gene_expression (expression) of Cx43
18) Confidence 0.76 Published 2009 Journal Chin. Med. J. Section Body Doc Link 19187618 Disease Relevance 0 Pain Relevance 0
Expression of connexin43 (Cx43), the major myometrial gap junction protein, is increased during delivery.
Gene_expression (Expression) of Cx43
19) Confidence 0.75 Published 2006 Journal J. Cell. Sci. Section Abstract Doc Link 16595547 Disease Relevance 0.20 Pain Relevance 0.10
In another model of loss of Cx43 expression, the heart-specific conditional knockout of Cx43, we observed a reduction in APD with correspondingly increased outward potassium currents (9).
Gene_expression (expression) of Cx43 in heart associated with targeted disruption and action potential duration
20) Confidence 0.67 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Body Doc Link PMC2614590 Disease Relevance 0.20 Pain Relevance 0.12

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