INT134822

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Context Info
Confidence 0.72
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 4.20
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Gja1) Golgi apparatus (Gja1) transmembrane transport (Gja1)
cell-cell signaling (Gja1) cytoplasm (Gja1) signal transducer activity (Gja1)
Anatomy Link Frequency
cardiomyocytes 3
visceral 1
smooth muscle 1
ependymal cells 1
plaques 1
Gja1 (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 1 99.68 Very High Very High Very High
Inflammation 9 99.66 Very High Very High Very High
Dismenorea 14 99.36 Very High Very High Very High
Acupuncture 6 98.88 Very High Very High Very High
Visceral pain 1 98.28 Very High Very High Very High
analgesia 1 93.36 High High
Peripheral nerve injury 6 88.84 High High
imagery 104 86.36 High High
chemokine 2 80.00 Quite High
Glutamate 20 73.28 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 24 100.00 Very High Very High Very High
Adenocarcinoma 18 100.00 Very High Very High Very High
INFLAMMATION 14 99.66 Very High Very High Very High
Cancer 244 99.56 Very High Very High Very High
Dysmenorrhea 1 99.36 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 98.28 Very High Very High Very High
Apoptosis 17 98.16 Very High Very High Very High
Premature Birth 2 96.32 Very High Very High Very High
Injury 83 94.92 High High
Colon Cancer 64 94.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of connexin43 (Cx43), the major myometrial gap junction protein, is increased during delivery.
Gene_expression (Expression) of connexin43
1) Confidence 0.72 Published 2006 Journal J. Cell. Sci. Section Abstract Doc Link 16595547 Disease Relevance 0.20 Pain Relevance 0.10
[Influence of connexin 43 gene knockout on the analgesic effect of acupuncture in visceral pain mice].
Gene_expression (knockout) of connexin 43 in visceral associated with targeted disruption, visceral pain, analgesic and acupuncture
2) Confidence 0.65 Published 2008 Journal Zhen Ci Yan Jiu Section Title Doc Link 18386636 Disease Relevance 0.10 Pain Relevance 0.39
Compared with the corresponding model group, Oct-R and Vas-R mRNA expressions and Oct-R expression of acupuncture and Yimucao Gao groups in Cx43 (+/+) mice, and those of Yimucao Gao group in Cx43 (+/-) mice were down-regulated significantly (P<0.05).
Gene_expression (expression) of Cx43
3) Confidence 0.58 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 19288895 Disease Relevance 0 Pain Relevance 0
Compared with the corresponding model group, Oct-R and Vas-R mRNA expressions and Oct-R expression of acupuncture and Yimucao Gao groups in Cx43 (+/+) mice, and those of Yimucao Gao group in Cx43 (+/-) mice were down-regulated significantly (P<0.05).
Gene_expression (expression) of Cx43
4) Confidence 0.58 Published 2008 Journal Zhen Ci Yan Jiu Section Body Doc Link 19288895 Disease Relevance 0 Pain Relevance 0
We have recently shown that short-term pacing in the mouse is associated with changes in connexin43 (Cx43) expression and localization but not with increased inducibility into sustained arrhythmias.
Gene_expression (expression) of connexin43
5) Confidence 0.49 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Abstract Doc Link PMC2614590 Disease Relevance 0.07 Pain Relevance 0
Decreased connexin43 expression in the mouse heart potentiates pacing-induced remodeling of repolarizing currents

Gap junction redistribution and reduced expression, a phenomenon termed gap junction remodeling (GJR), is often seen in diseased hearts and may predispose toward arrhythmias.

Gene_expression (expression) of connexin43 in heart
6) Confidence 0.49 Published 2008 Journal American Journal of Physiology - Heart and Circulatory Physiology Section Title Doc Link PMC2614590 Disease Relevance 0.07 Pain Relevance 0.03
Conceivably, more efficient cardiogenic differentiation within the environment of infracted heart may have yielded higher Connexin 43 expression and maturation of ion currents in engrafted cardiomyocytes resulting in improved functional in vivo integration.
Gene_expression (expression) of Connexin 43 in cardiomyocytes
7) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.29 Pain Relevance 0
This low conduction velocity was consistent with observed sparse Connexin 43 expression and possibly contributed by immature (or mixed from nodal, atrial, and ventricular cells) electrophysiological phenotype of CPC-derived cardiomyocytes [31].
Gene_expression (expression) of Connexin 43 in cardiomyocytes
8) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.27 Pain Relevance 0
Among the group of miscellenous genes, differential expression of connexin-43, ferritin light chain and the ?
Gene_expression (expression) of connexin-43
9) Confidence 0.15 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC161801 Disease Relevance 0.18 Pain Relevance 0.07
However, unlike the NRVMs that expressed Connexin 43 in relatively long plaques at the sites of cell contacts, the CPC-derived cardiomyocytes expressed Connexin 43 sporadically and irregularly.
Gene_expression (expressed) of Connexin 43 in cardiomyocytes
10) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0 Pain Relevance 0.09
However, unlike the NRVMs that expressed Connexin 43 in relatively long plaques at the sites of cell contacts, the CPC-derived cardiomyocytes expressed Connexin 43 sporadically and irregularly.
Gene_expression (expressed) of Connexin 43 in plaques
11) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0 Pain Relevance 0.09
The differential expression of transferrin receptor, P4-kinase, STAT-5 and connexin-43 confirm already published studies from other research groups [16,33-35].
Gene_expression (expression) of connexin-43
12) Confidence 0.11 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC161801 Disease Relevance 0 Pain Relevance 0
Analysis of these signatures revealed over-expression of inflammatory genes and under-expression of developmental genes, including smooth muscle genes like GATA6 and connexin 43.
Gene_expression (expression) of connexin 43 in smooth muscle associated with inflammation
13) Confidence 0.08 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2777855 Disease Relevance 0.46 Pain Relevance 0.05
The expression of connexin43 after exposure to IR has shown to vary in
Gene_expression (expression) of connexin43
14) Confidence 0.06 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0.07 Pain Relevance 0
The modulation of connexin43

(associated with gap junctions) expression has been shown after exposure to IR [10].

Gene_expression (expression) of connexin43
15) Confidence 0.06 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0.41 Pain Relevance 0.04
Immunohistochemistry and electromicroscopy demonstrated that AQP4 deletion resulted in decreased expression of gap junction protein connexin43 (Cx43) [41], that is the main gap-junction protein in astrocytes as well as ependymal cells [77].
Gene_expression (expression) of junction protein connexin43 in ependymal cells
16) Confidence 0.03 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.44 Pain Relevance 0
Using CEA-producing human colonic adenocarcinoma cells (CX-1) grown as tumor xenografts that were subcutaneously implanted on the flank in Swiss nude mice, they demonstrated the feasibility of gamma probe detection of 131I-labeled anti-CEA polyclonal baboon antibodies within such subcutaneous implants and demonstrated the greater sensitivity of the gamma detection probe as compared to gamma camera imaging for small tumor implants [289,290].
Gene_expression (producing) of CX-1 in CX-1 associated with adenocarcinoma, cancer and imagery
17) Confidence 0.02 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2653072 Disease Relevance 1.26 Pain Relevance 0.04
However, the gap-junction protein Cx43 has been shown to modulate both astrocytic P2Y1 receptor expression levels [74] and pharmacological function [75].
Gene_expression (expression) of gap-junction protein Cx43
18) Confidence 0.01 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583203 Disease Relevance 0.28 Pain Relevance 0.10

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