INT134824

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.61
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Top2a) nuclear chromosome (Top2a) aging (Top2a)
chromosome segregation (Top2a) enzyme binding (Top2a) DNA binding (Top2a)
Top2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 2 71.12 Quite High
Disease Link Frequency Relevance Heat
Chromosome Aberrations 8 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since endoreduplication has been linked to inhibition of topoisomerase II, the topoisomerase II inhibitor ICRF-193 was used as a control inducer of endoreduplication (0.1-0.5 microM), increasing the number of endoreduplicated cells from 0% (control) to 3.5% (0.5 microM).
Negative_regulation (inhibition) of topoisomerase II
1) Confidence 0.41 Published 2006 Journal Mutagenesis Section Abstract Doc Link 16595588 Disease Relevance 0.33 Pain Relevance 0.07
Both eugenol and ICRF-193 were also assayed for inhibition of topoisomerase II, and both showed a dose-dependent inhibitory effect, with ICRF-193 being a more potent inhibitor.
Negative_regulation (inhibition) of topoisomerase II
2) Confidence 0.41 Published 2006 Journal Mutagenesis Section Abstract Doc Link 16595588 Disease Relevance 0.28 Pain Relevance 0.06

General Comments

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