INT134842

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Context Info
Confidence 0.78
First Reported 2006
Last Reported 2006
Negated 1
Speculated 1
Reported most in Abstract
Documents 1
Total Number 10
Disease Relevance 6.73
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (YAP1) cytosol (YAP1) nucleoplasm (YAP1)
nucleus (YAP1) cytoplasm (YAP1)
Anatomy Link Frequency
pancreas 2
ducts 1
YAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 10 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adenocarcinoma 70 99.96 Very High Very High Very High
Pancreatic Cancer 10 99.92 Very High Very High Very High
Cancer 30 98.36 Very High Very High Very High
Pancreatitis 10 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of TGF-beta1 on Smad7 and YAP65 mRNA expression were analyzed by quantitative RT-PCR.
Gene_expression (expression) of YAP65 mRNA
1) Confidence 0.78 Published 2006 Journal Int. J. Mol. Med. Section Abstract Doc Link 16596258 Disease Relevance 0.68 Pain Relevance 0.08
Enhanced expression of YAP65 mRNA was identified by Northern blotting and quantitative RT-PCR in PDAC in comparison to the normal pancreas (2.5-fold increase) and to chronic pancreatitis (1.3-fold increase).
Gene_expression (expression) of YAP65 mRNA in pancreas associated with adenocarcinoma and chronic pancreatitis
2) Confidence 0.78 Published 2006 Journal Int. J. Mol. Med. Section Abstract Doc Link 16596258 Disease Relevance 0.75 Pain Relevance 0.09
In the present study, the expression of YAP65 in PDAC was analyzed in order to elucidate the potential role of this molecule in the pathogenesis of pancreatic cancer.
Spec (analyzed) Gene_expression (expression) of YAP65 associated with adenocarcinoma and pancreatic cancer
3) Confidence 0.78 Published 2006 Journal Int. J. Mol. Med. Section Abstract Doc Link 16596258 Disease Relevance 0.51 Pain Relevance 0
In conclusion, YAP65 is expressed mainly in centroacinar and small ductal cells in the normal pancreas.
Gene_expression (expressed) of YAP65 in pancreas
4) Confidence 0.78 Published 2006 Journal Int. J. Mol. Med. Section Abstract Doc Link 16596258 Disease Relevance 0.73 Pain Relevance 0.08
Immunohistochemistry was carried out to localize and quantify YAP65 expression in relation to Smad7 expression and Smad4 mutations.
Gene_expression (expression) of YAP65
5) Confidence 0.78 Published 2006 Journal Int. J. Mol. Med. Section Abstract Doc Link 16596258 Disease Relevance 0.62 Pain Relevance 0.07
YAP65 mRNA expression levels in human pancreatic tissue samples and cell lines were analyzed by Northern blotting and quantitative RT-PCR.
Gene_expression (expression) of YAP65 mRNA
6) Confidence 0.78 Published 2006 Journal Int. J. Mol. Med. Section Abstract Doc Link 16596258 Disease Relevance 0.57 Pain Relevance 0.06
In PDAC, YAP65 is present in tubular complexes and to a lesser extent in cancer cells.
Gene_expression (present) of YAP65 associated with adenocarcinoma and cancer
7) Confidence 0.78 Published 2006 Journal Int. J. Mol. Med. Section Abstract Doc Link 16596258 Disease Relevance 0.67 Pain Relevance 0.07
Yes-associated protein (YAP65) in relation to Smad7 expression in human pancreatic ductal adenocarcinoma.
Gene_expression (expression) of YAP65 associated with adenocarcinoma
8) Confidence 0.67 Published 2006 Journal Int. J. Mol. Med. Section Title Doc Link 16596258 Disease Relevance 0.64 Pain Relevance 0.06
There was no correlation between YAP65 immunostaining and Smad7 staining or Smad4 mutations in the cancer samples.
Gene_expression (immunostaining) of YAP65 associated with cancer
9) Confidence 0.67 Published 2006 Journal Int. J. Mol. Med. Section Abstract Doc Link 16596258 Disease Relevance 0.80 Pain Relevance 0.08
In the normal pancreas, YAP65 was absent in acinar cells, large ducts and islet cells, but exhibited moderate to strong immunoreactivity in centroacinar cells and ductules.
Neg (absent) Gene_expression (absent) of YAP65 in ducts
10) Confidence 0.60 Published 2006 Journal Int. J. Mol. Med. Section Abstract Doc Link 16596258 Disease Relevance 0.77 Pain Relevance 0.10

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