INT134873

Context Info Confidence 0.80 First Reported 2006 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.50 Pain Relevance 1.42

plasma membrane (Dlg4) protein complex assembly (Dlg4) response to stress (Dlg4) cytoplasm (Dlg4)

Anatomy Link Frequency descending colon 1 Dlg4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Morphine 11 99.44 depression 3 98.96 Spinal cord 2 97.96 Action potential 6 95.12 Dextromethorphan 3 90.96 dorsal root ganglion 1 81.48 antagonist 7 78.16 imagery 20 75.64 Hippocampus 1 75.00 lidocaine 1 73.52

Disease Link Frequency Relevance Heat Depression 3 98.96 Ganglion Cysts 1 81.48 Stress Incontinence 3 75.00 Opiate Addiction 1 41.48 Pathologic Processes 2 5.00 Functional Bowel Disorder 1 5.00 Nervous System Malformation 1 5.00 Complex Regional Pain Syndromes 1 5.00 Increased Venous Pressure Under Development 1 5.00 Stress 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A potential concern is the use of an exogenous form of PSD-95 fused to EGFP (an ?

Phosphorylation (form) of PSD-95

1) Confidence 0.80 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2693930 Disease Relevance 0 Pain Relevance 0.04

Collectively, the study demonstrates that maternal exposure to morphine decreases the magnitude of PSD-95, nNOS, the phosphorylation of CREB(Serine-133), and LTD expression in hippocampal CA1 subregion of young offspring (e.g., P14).

Phosphorylation (phosphorylation) of PSD-95 associated with depression and morphine

2) Confidence 0.67 Published 2006 Journal Hippocampus Section Abstract Doc Link 16598705 Disease Relevance 0.27 Pain Relevance 0.93

When compared with a baseline reflex activity with a single action potential evoked by the TS before the administration of test agents, MO instillation into the descending colon sensitized the evoked activity characterized by elongated firing in the reflex activity in association with increased protein levels of Cdk5, PSD95, and phosphorylated NR2B (pNR2B) but not of total NR2B (tNR2B) in the spinal cord tissue.

Phosphorylation (phosphorylated) of PSD95 in descending colon associated with action potential and spinal cord

3) Confidence 0.39 Published 2009 Journal Pain Section Abstract Doc Link 19167822 Disease Relevance 0.23 Pain Relevance 0.46

General Comments

This test has worked.