INT134873

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Context Info
Confidence 0.80
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.50
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dlg4) protein complex assembly (Dlg4) response to stress (Dlg4)
cytoplasm (Dlg4)
Anatomy Link Frequency
descending colon 1
Dlg4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 11 99.44 Very High Very High Very High
depression 3 98.96 Very High Very High Very High
Spinal cord 2 97.96 Very High Very High Very High
Action potential 6 95.12 Very High Very High Very High
Dextromethorphan 3 90.96 High High
dorsal root ganglion 1 81.48 Quite High
antagonist 7 78.16 Quite High
imagery 20 75.64 Quite High
Hippocampus 1 75.00 Quite High
lidocaine 1 73.52 Quite High
Disease Link Frequency Relevance Heat
Depression 3 98.96 Very High Very High Very High
Ganglion Cysts 1 81.48 Quite High
Stress Incontinence 3 75.00 Quite High
Opiate Addiction 1 41.48 Quite Low
Pathologic Processes 2 5.00 Very Low Very Low Very Low
Functional Bowel Disorder 1 5.00 Very Low Very Low Very Low
Nervous System Malformation 1 5.00 Very Low Very Low Very Low
Complex Regional Pain Syndromes 1 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A potential concern is the use of an exogenous form of PSD-95 fused to EGFP (an ?
Phosphorylation (form) of PSD-95
1) Confidence 0.80 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2693930 Disease Relevance 0 Pain Relevance 0.04
Collectively, the study demonstrates that maternal exposure to morphine decreases the magnitude of PSD-95, nNOS, the phosphorylation of CREB(Serine-133), and LTD expression in hippocampal CA1 subregion of young offspring (e.g., P14).
Phosphorylation (phosphorylation) of PSD-95 associated with depression and morphine
2) Confidence 0.67 Published 2006 Journal Hippocampus Section Abstract Doc Link 16598705 Disease Relevance 0.27 Pain Relevance 0.93
When compared with a baseline reflex activity with a single action potential evoked by the TS before the administration of test agents, MO instillation into the descending colon sensitized the evoked activity characterized by elongated firing in the reflex activity in association with increased protein levels of Cdk5, PSD95, and phosphorylated NR2B (pNR2B) but not of total NR2B (tNR2B) in the spinal cord tissue.
Phosphorylation (phosphorylated) of PSD95 in descending colon associated with action potential and spinal cord
3) Confidence 0.39 Published 2009 Journal Pain Section Abstract Doc Link 19167822 Disease Relevance 0.23 Pain Relevance 0.46

General Comments

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