INT134875

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Context Info
Confidence 0.70
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.21
Pain Relevance 3.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos1) aging (Nos1) enzyme binding (Nos1)
cytoplasm (Nos1) cytosol (Nos1) oxidoreductase activity (Nos1)
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 33 99.28 Very High Very High Very High
depression 9 98.96 Very High Very High Very High
Rostral ventrolateral medulla 110 92.80 High High
Dextromethorphan 9 90.64 High High
Neuronal nitric oxide synthase 3 80.76 Quite High
Hippocampus 3 75.00 Quite High
Central nervous system 3 67.20 Quite High
withdrawal 3 63.96 Quite High
Clonidine 2 50.00 Quite Low
cerebral cortex 2 38.68 Quite Low
Disease Link Frequency Relevance Heat
Depression 9 98.96 Very High Very High Very High
Death 124 88.40 High High
Opiate Addiction 3 64.32 Quite High
Apoptosis 4 49.24 Quite Low
Middle Cerebral Artery Infarction 2 35.80 Quite Low
INFLAMMATION 2 31.24 Quite Low
Poisoning 14 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 8 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collectively, the study demonstrates that maternal exposure to morphine decreases the magnitude of PSD-95, nNOS, the phosphorylation of CREB(Serine-133), and LTD expression in hippocampal CA1 subregion of young offspring (e.g., P14).
Phosphorylation (phosphorylation) of nNOS associated with depression and morphine
1) Confidence 0.70 Published 2006 Journal Hippocampus Section Abstract Doc Link 16598705 Disease Relevance 0.27 Pain Relevance 0.92
Western blot analyses complemented the pharmacological evidence by demonstrating that clonidine-ethanol combination inhibits phosphorylation (activation) of nNOS (p-nNOS) and increases the level of phosphorylated eNOS (p-eNOS) in the LC; the change in p-nNOS was paralleled by similar change in LC p-ERK1/2.
Phosphorylation (phosphorylation) of nNOS
2) Confidence 0.62 Published 2010 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 20028349 Disease Relevance 0 Pain Relevance 0
In addition, prenatal morphine exposure reduced not only the expression of nNOS and the phosphorylation of cAMP responsive element-binding protein at serine 133 (CREB(Serine-133)), but also the magnitude of long-term depression (LTD) at P14.
Phosphorylation (phosphorylation) of nNOS associated with depression and morphine
3) Confidence 0.53 Published 2006 Journal Hippocampus Section Abstract Doc Link 16598705 Disease Relevance 0.31 Pain Relevance 1.14
In addition, prenatal morphine exposure reduced not only the expression of nNOS and the phosphorylation of cAMP responsive element-binding protein at serine 133 (CREB(Serine-133)), but also the magnitude of long-term depression (LTD) at P14.
Phosphorylation (phosphorylation) of nNOS associated with depression and morphine
4) Confidence 0.53 Published 2006 Journal Hippocampus Section Abstract Doc Link 16598705 Disease Relevance 0.31 Pain Relevance 1.14
It follows that MNK1/2 may enhance phosphorylation of NOS I on activation by MEK/ERK.
Phosphorylation (phosphorylation) of NOS I
5) Confidence 0.29 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.16 Pain Relevance 0.11
Another possibility is for ERK to exert posttranslational modification by phosphorylation of NOS I protein.
Phosphorylation (phosphorylation) of NOS I protein
6) Confidence 0.29 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.17 Pain Relevance 0.12

General Comments

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