INT134876

Context Info Confidence 0.35 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.27 Pain Relevance 0.93

plasma membrane (Dlg4) protein complex assembly (Dlg4) response to stress (Dlg4) cytoplasm (Dlg4)

Dlg4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Morphine 11 99.70 depression 3 98.96 Dextromethorphan 3 91.48 Hippocampus 1 75.00 Neuronal nitric oxide synthase 1 58.44 Central nervous system 1 44.88 withdrawal 1 41.64

Disease Link Frequency Relevance Heat Depression 3 98.96 Opiate Addiction 1 42.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Collectively, the study demonstrates that maternal exposure to morphine decreases the magnitude of PSD-95, nNOS, the phosphorylation of CREB(Serine-133), and LTD expression in hippocampal CA1 subregion of young offspring (e.g., P14).

Negative_regulation (magnitude) of Phosphorylation (phosphorylation) of PSD-95 associated with depression and morphine

1) Confidence 0.35 Published 2006 Journal Hippocampus Section Abstract Doc Link 16598705 Disease Relevance 0.27 Pain Relevance 0.93

General Comments

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