INT134889

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 12.65
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFRSF11A) cell-cell signaling (TNFRSF11A)
Anatomy Link Frequency
joint 1
blood 1
endothelial cells 1
TNFRSF11A (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 19 98.64 Very High Very High Very High
aspirin 6 95.60 Very High Very High Very High
Pain 11 88.48 High High
Inflammation 31 81.84 Quite High
rheumatoid arthritis 37 81.76 Quite High
Migraine 3 80.76 Quite High
Calcium channel 1 80.24 Quite High
withdrawal 1 76.80 Quite High
cytokine 29 73.08 Quite High
cINOD 1 63.64 Quite High
Disease Link Frequency Relevance Heat
Cancer 315 100.00 Very High Very High Very High
Targeted Disruption 6 99.64 Very High Very High Very High
Metastasis 377 99.62 Very High Very High Very High
Apoptosis 123 99.60 Very High Very High Very High
Parkinson's Disease 6 99.60 Very High Very High Very High
Osteoporosis 183 99.56 Very High Very High Very High
Arthritis 19 98.64 Very High Very High Very High
Bone Cancer 8 98.08 Very High Very High Very High
Osteolysis 64 97.60 Very High Very High Very High
Skin Cancer 3 96.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The use of iloprost to improve blood flow and bisphosphonates and RANK-ligand inhibition to reduce osteoclastic resorption of remaining trabecular structures are as yet unproven strategies.
Negative_regulation (inhibition) of RANK in blood associated with osteoporosis
1) Confidence 0.42 Published 2006 Journal Nephrology (Carlton) Section Abstract Doc Link 17199798 Disease Relevance 1.34 Pain Relevance 0.49
Bisphosphonates and RANK ligand inhibitors for the treatment and prevention of metastatic bone disease.
Negative_regulation (inhibitors) of RANK associated with bone cancer
2) Confidence 0.42 Published 2010 Journal Eur. J. Cancer Section Title Doc Link 20347292 Disease Relevance 1.04 Pain Relevance 0.09
However, blocking the OPG/RANK/RANKL pathway with RANK-Fc had no effect on tumor cells in nonosseous sites; the decrease in tumor burden following inhibition of the tumor-mediated osteolysis is an indirect effect secondary to interruption of the vicious cycle of osteolytic metastasis [43-45].
Negative_regulation (decrease) of RANK associated with cancer, osteolysis and metastasis
3) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 1.58 Pain Relevance 0.03
OPG is a negative regulator of the RANK/RANKL pathway and prevents RANK-RANKL interaction by sequestering RANKL.
Negative_regulation (regulator) of RANK
4) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 0.69 Pain Relevance 0.04
A prior study in our laboratory using a mouse intratibial injection model of metastasis demonstrated that blocking the RANK-RANKL interaction by RANK-Fc (a recombinant soluble fusion protein consisting of extracellular domain of RANK coupled with the Fc domain of human IgG) limits the formation of osteolytic bone lesions [44].
Negative_regulation (blocking) of RANK associated with metastasis
5) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 1.32 Pain Relevance 0.04
However, blocking the OPG/RANK/RANKL pathway with RANK-Fc had no effect on tumor cells in nonosseous sites; the decrease in tumor burden following inhibition of the tumor-mediated osteolysis is an indirect effect secondary to interruption of the vicious cycle of osteolytic metastasis [43-45].
Negative_regulation (blocking) of RANK associated with cancer, osteolysis and metastasis
6) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 1.50 Pain Relevance 0.03
The results showed that (i) aspirin, fenofibrate and clofibrate decrease significantly the MCP-1 expression and secretion in human endothelial cells; (ii) the high glucose up-regulated expression of MCP-1 in endothelial cells was significantly reduced by inhibitors of NF-kB and reactive oxygen species; (iii) all drugs notably decrease the level of the reactive oxygen species and activation of NF-kB and AP-1.
Negative_regulation (inhibitors) of NF-kB in endothelial cells associated with aspirin
7) Confidence 0.29 Published 2006 Journal Vascul. Pharmacol. Section Abstract Doc Link 16600694 Disease Relevance 0.36 Pain Relevance 0.32
Meanwhile data have showed that PTL-induced apoptosis is associated with inhibition of transcription factor nuclear factor-kappa B (NF-kB) [3,10], mitochondrial dysfunction and increase of reactive oxygen [11,12].
Negative_regulation (inhibition) of NF-kB associated with parkinson's disease and apoptosis
8) Confidence 0.12 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 1.31 Pain Relevance 0.12
Hence, the chemotherapeutic potential of NF-kB inhibitors should be evaluated.
Negative_regulation (inhibitors) of NF-kB
9) Confidence 0.12 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.91 Pain Relevance 0
Meanwhile data have showed that PTL-induced apoptosis is associated with inhibition of transcription factor nuclear factor-kappa B (NF-kB) [3,10], mitochondrial dysfunction and increase of reactive oxygen [11,12].
Negative_regulation (inhibition) of transcription factor nuclear factor-kappa B associated with parkinson's disease and apoptosis
10) Confidence 0.10 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 1.31 Pain Relevance 0.12
Experiments that have induced arthritis in osteoclast-free models, such as c-fos knockout mice [7] or mice deficient in either rankl or rank, have shown that osteoclasts are essential for joint destruction [8,9].
Negative_regulation (deficient) of rank in joint associated with targeted disruption and arthritis
11) Confidence 0.09 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860063 Disease Relevance 1.31 Pain Relevance 0.49

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